Historical Tables, 58 B.C.–A.D. 1965

Steinberg, S. H.

doi:10.1007/978-1-349-86217-7

Cited by 2 publications

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“…21]. Since the abnormal B-cell activity in SLE probably is a consequence of altered regulatory T-cell functions, as is also supported by the defective T-ccll suppressor activity detectable in the NZB/NZW murine model [4,12,26], it is likely that the excessive antibody production in the human disease may be related to the selective deficiency in T(i suppressor cells.…”

Section: Discussionmentioning

confidence: 99%

“…Such aberration of the immunoregulatory control may be a reflection of a defective activity of suppressor T cells. This view is supported by studies of NZB/NZW mice which have deficient suppressor cell function and develop a disease similar to human SLE [4,12,26]. In addition, it has recently been reported that patients alTccted by SLE may have deficiencies in the proportion ofT lymphocytes and altered suppressor cell functions [I, 2].…”

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confidence: 92%

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Human T‐Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus

et al. 1979

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Sharply reduced proportions of T cells with Fc receptors for IgG (TG cells) were observed in blood samples from patients with systemic lupus erythematosus (SLE), mainly with active disease. This T-cell subset has previously been shown to be a suppressor in the pokeweed mitogen (PWM)-dependent B-cell differentiation. In contrast, the percentages of T cells with Fc receptors for IgM (TM cells), which have been shown to help immunoglobulin production, were not different from those of normals. TG cells present in the circulation of SLE patients were analysed for their functional capacities in antibody-dependent cell-mediated cytotoxicity and in the suppression of a PWM-induced B-cell differentiation. In both these assays TG cells from SLE patients had normal effector cell activity. This suggests that thr than a qualitative type.

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Section: Discussionmentioning

confidence: 99%

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confidence: 92%

Human T‐Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus

et al. 1979

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“…A single autosomal recessive gene, Ipr, is capable of inducing autoimmunity in MRL, C57BL/6,C3H, and AKR mice [1]. Stem cells in the bone marrow of MRL/lpr mice can transfer spontaneous autoimmune disease to irradiated recipients, provided a thymic microenvironment is present [9,11], Thymectomized recipients do not develop autoimmunity, but animals grafted with MRL/++ thymus develop autoantibodies, lymphadenopathy, and immune complex nephritis.…”

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confidence: 99%

“…There is a deficiency of Lyt-2-positive cells [12] and of interleukin-2 production and response (1,14], Besides thymectomy, three other approaches are capable of suppressing disease in MRL/lpr mice. Low-dose whole-body irradiation (300 rad) or total lymphoid irradiation is beneficial [10], as is the administration of male sex hormones [8,9] and prostaglandin E 13|. We have explored in detail the basis for the therapeutic effect of low-dose irradiation and can associate it with the elimination of lapositive cells present in Ipr bone marrow.…”

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confidence: 99%

Suppression of Lymphoproliferation and Autoimmunity by Elimination of a Radiosensitive Bone Marrow Cell in Mice Bearing the lpr Gene

Dauphinée

Talal

1984

Scand J Immunol

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The autosomal recessive lpr gene (lymphoproliferative) has been bred into several normal strains of mice. Although the time of disease onset may vary, all of these lpr mice develop hypergammaglobulinaemia, antibodies to nucleoproteins, and massive lymphoproliferation. The abnormalities do not appear in their normal congenic counterparts, which lack the lpr gene. We studied the effects of sublethal whole-body X-irradiation (300 rads) on disease features and lymphocyte subpopulations by using flow cytometry. H-2k strains, C3H and MRL/++ and their autoimmune lpr counterparts, were killed at 1, 2, 4, 8 and 24 weeks after irradiation, which was given at 6-8 weeks of age. In the lpr mice, lymphoproliferation, autoimmunity, mortality and number of Ia+ cells were greatly reduced in the irradiated mice compared with nonirradiated controls. Abnormal cytofluorometric patterns seen with lpr thymocytes were corrected by the low-dose irradiation treatment. In addition, lethally irradiated lpr mice reconstituted with syngeneic bone marrow from low-dose irradiated mice exhibited retarded development of autoimmune disease. We conclude that the lymphoid alterations induced by X-irradiation reflect a recovery of immunologic control associated with suppression of autoimmune manifestations.

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Historical Tables, 58 B.C.–A.D. 1965

Cited by 2 publications

References 0 publications

Human T‐Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus

Human T‐Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus

Suppression of Lymphoproliferation and Autoimmunity by Elimination of a Radiosensitive Bone Marrow Cell in Mice Bearing the lpr Gene

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