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Liebermann-Meffert, D.; White, Harvey D.; Vaubel, E.

doi:10.1007/978-3-662-02374-7_10

Cited by 7 publications

(9 citation statements)

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“…Lymphoreticular organs, called milkey spots, occur throughout the greater omentum and may represent the barrier to peritoneal seeding [29]. The present data suggest that the release of tumor cells from lymphatic capillaries plays an important role in peritoneal dissemination.…”

Section: Discussionmentioning

confidence: 69%

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

et al. 2011

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ObjectiveTreatment options for patients with diffuse type gastric cancer (linitis plastica) are discussed controversial. It is sometimes discussed that these patients should be treated primarily in palliative intention conservative without resection.MethodsIn a single-center analysis, we investigated 120 patients with diffuse type gastric cancer. All patients underwent a total gastrectomy, 45 patients even a multivisceral resection because of infiltrating growth, or metastases. Serum tumor marker CEA, CA 72-4, and CA 19-9 were recorded in all patients before surgery. An immunocytochemical detection of free peritoneal tumor cells (FPTC) using Ber-EP4 antibody was correlated with tumor stage and survival. Median follow-up time was 38 months.ResultsComplete resection rate was 31% (n = 37). 61% (n = 73) of all patients had already distant metastases at the time of surgery, 80% of them peritoneal carcinomatosis. Median survival for the whole group was 8 months, after complete resection 17 months. Lavage cytology, distant metastases, resection rate, and CA19-9 levels had significant influence on survival.ConclusionA significant survival advantage for patients with diffuse type gastric cancer can only be achived after complete resection. We could define a subset of patients with an extremely poor prognosis even after surgical resection. Meticulous preoperative staging, including a diagnostic laparoscopy to exclude peritoneal carcinomatosis and free peritoneal tumor cells before resection should be mandatory in these patients.

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Section: Discussionmentioning

confidence: 69%

Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment

et al. 2011

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“…The greater omentum fits requirements 1–4, particularly if mobilized to a subcutaneous or intramuscular portion of the abdominal wall. The omentum has good arterial pedicles, numerous lymphatic vessels and exclusive portal drainage (19). The tissue has a high vascular density and allows for good neo-angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold

Berman¹,

O’Neil²,

Coffey³

et al. 2009

American Journal of Transplantation

148

129

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The aim of this study was to test whether an omental pouch can be used as an alternative site for islet implantation in diabetic monkeys. Here we report the successful engraftment of islets in diabetic cynomolgus monkeys when loaded on a synthetic biodegradable scaffold and placed in an omental pouch. One autologous and 5 allogeneic diabetic monkey transplants under the cover of steroid-free immune suppression were undertaken. Fasting blood glucose (FBG) and c-peptide (CP), exogenous insulin requirements (EIR), intravenous glucose tolerance test (IVGTT), A1C and histopathology were used to assess islet engraftment and survival. All animals achieved CP levels > 1.0 ng/ml following transplant, a 66 – 92% post-transplant decrease in EIR and reduced A1C. Following graft removal, CP became negative and histopathological analysis of the explanted grafts demonstrated well granulated and well vascularized, insulin positive islets, surrounded by T cell subsets and macrophages. Compared to intrahepatic allogeneic islet transplants (n=20), there was a delayed engraftment for omental pouch recipients but similar levels of CP production were ultimately achieved, with a broad range of IEQ/kg transplanted in both sites. Our results suggest this extrahepatic transplantation site has potential as an alternative site for clinical islet cell transplantation.

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“…Thirdly it is still controversial whether or not reactivated milky spots occur during infec tious diseases even during peritoneal disorders. While Liebermann-Meffert and White [ 14] found them in nor mal subjects, Loeweneck et al [16] reported on the absence of them in the omentum of adults with chronic peritoneal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…The proposed classification for omental spots (pri mary, inactive and secondary) by Liebermann-Meffert and White [ 14] cannot be followed for pleural ones. For one thing pleural spots are not present in the prenatal period |3] as do primary spots of the omentum.…”

Section: Discussionmentioning

confidence: 99%