History and Clinical Presentation of the Chemically Sensitive Patient

Ross, Gerald H.

doi:10.1177/074823379200800403

Cited by 18 publications

(12 citation statements)

References 2 publications

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“…effects of air aldehydes and VOCs (1-4) because of the increase of air tightness of recent buildings and houses in well-developed countries. MCS is caused by multiple chemical substances that are found not only in the outdoor environment, such as pesticides, but also in indoor air and which are similar to substances inducing SBS (5)(6)(7)(8). In addition, lowdose exposure to asbestos causes mesothelioma and represents a situation that includes adverse effects on health associated with indoor air circumstances since most asbestos is used in architectural materials for heat/fire resistance (38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Two Weeks of Permanence in Negatively-Charged Air Conditions Causes Alteration of Natural Killer Cell Function

Takahashi

Otsuki

Mase

et al. 2009

Int J Immunopathol Pharmacol

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The effects of negatively-charged air conditions were analyzed as one of the approaches to improve health and quality of life. We previously reported that the use of a charcoal coating and application of an electric voltage yielded predominantly negatively-charged particles in an experimental room, and that 2.5 hours of living in these conditions caused a slight activation of the immune system (slight elevation of serum interleukin (IL)-2), regulated blood flow, and stabilized the autonomic nervous system when compared with control conditions (no dominance of negatively-charged particles). In this study, we expanded the previous study and placed 15 subjects in negatively-charged air conditions for two weeks during the night and analyzed various biological parameters. Although individual biological reactions differed from subject to subject, natural killer (NK) cell activity increased significantly following living in negatively-charged air conditions. Taken together, the results of the previous investigation and those ofthis study show that repeated elevation ofIL-2 (although it immediately returned to the baseline level) causes chronic and recurrent stimulation to NK cells and results in the steady activation of NK cells. Negatively-charged air particles may be a good tool to improve health and quality of life.The health effects of indoor-air have recently received attention, and some of the adverse effects of indoor-air include sick-building syndrome (SBS) (1-4) and multiple chemical sensitivity syndrome (MCS) (5-8). These diseases are mainly caused by indoor-air aldehydes and volatile organic compounds (VOCs) that affect the human psycho-neuro-endocrineimmune (PNEI) network (9-13). The concept of the PNEI network (PNEI-NW) has evolved in the past few decades and is thought to include a close relationship between immunoregulation and brain functions. Particular emphasis is given to circuits involving immune cell products, the hypothalamuspituitary-adrenal axis, and the sympathetic nervous system (9-13). There is increasing evidence that brain cytokines play an important role in brain

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Section: Discussionmentioning

confidence: 99%

Two Weeks of Permanence in Negatively-Charged Air Conditions Causes Alteration of Natural Killer Cell Function

Takahashi

Otsuki

Mase

et al. 2009

Int J Immunopathol Pharmacol

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“…Clinical samples studied by some authors (98)(99)(100)(101)(102) were also predominantly women. In their large representative household population study, Meggs et al (11) found that 39% of women and 24% of men reported chemical sensitivity.…”

Section: Gendermentioning

confidence: 99%

Multiple chemical sensitivity and idiopathic environmental intolerance (part one)

Watanabe

Tonori

Aizawa

2003

Environ Health Prev Med

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Multiple chemical sensitivity/idiopathic environmental intolerance (MCS/IEI) is a commonly used diagnostic term for a group of symptoms. These symptoms have been described and commented on for more than 15 years in the USA. Recently, it has also been observed in Japan. The main features of this syndrome are multiple symptoms involving in multiple organ systems that are precipitated by a variety of chemical substances with relapses and exacerbation under certain conditions when exposed to very low levels which do not affect the population at large. There are no laboratory markers or specific investigative findings. Although traditional medical organizations have not agreed on a definition for this syndrome due to the lack of obvious evidence to demonstrate the existence of these symptoms, it is being increasingly recognized. It constitutes an increasing percentage of the caseload at occupational/environmental medical clinics.Part one of this review article discusses pathophysiological theories, substances which cause symptoms, prevalence in the general and specific populations, past history and family history, and clinical symptoms of MCS/IEI patients.

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“…Because research on treatments for MCS is sparse, people have few data on which to rely when choosing interventions. Physicians have described health findings from patient samples (Bell et al 1995;Galland 1987;Heuser et al 1992;Lieberman and Craven 1998;Ross 1992a) and suggested treatment strategies (Jewett 1992;Ross 1992b;Ziem 1992), but only a small number of published studies describe MCS treatment and follow-up (Lax and Henneberger 1995). In addition, only three studies to date have examined patients' assessments of a large number of health interventions for MCS (Gibson 2000;Johnson 1996Johnson , 1997aJohnson , 1997bJohnson , 1998Leroy et al 1996).…”

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confidence: 99%

Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity.

Gibson

Elms

Ruding

2003

Environ Health Perspect

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Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities often spread over time, first to related chemicals and then to other classes of chemicals. This study examined self-reported perceived treatment efficacy of 101 treatments used by 917 persons with self-reported MCS. Treatments examined included environmental medicine techniques, holistic therapies, individual nutritional supplements, detoxification techniques, body therapies, Eastern-origin techniques, newer therapies, prescription items, and others. The three most highly rated treatments were creating a chemical-free living space, chemical avoidance, and prayer. Both creating a chemical-free living space and chemical avoidance were rated by 95% of respondents as helpful. Results for most therapies were mixed. Participants had consulted a mean of 12 health care providers and spent over one-third of their annual income on health care costs. We discuss this drain on personal resources and describe respondents' attitudes toward the possibility of healing from MCS.

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History and Clinical Presentation of the Chemically Sensitive Patient

Cited by 18 publications

References 2 publications

Two Weeks of Permanence in Negatively-Charged Air Conditions Causes Alteration of Natural Killer Cell Function

Two Weeks of Permanence in Negatively-Charged Air Conditions Causes Alteration of Natural Killer Cell Function

Multiple chemical sensitivity and idiopathic environmental intolerance (part one)

Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity.

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