Reservoir models typically contain hundreds-of-thousands to millions of grid cells in which petrophysical properties such as porosity and permeability vary on a cell-to-cell basis. However, although the petrophysical properties of rocks do vary on a point-to-point basis, this variability is not equivalent to the cell-to-cell variations in models. We investigate the impact of removing cell-to-cell variability on predictions of fluid flow in reservoir models. We remove cell-to-cell variability from models containing hundreds of thousands of unique porosity and permeability values to yield models containing just a few tens of unique porosity and permeability values grouped into a few internally homogeneous domains. The flow behavior of the original model is used as a reference. We find that the impact of cell-to-cell variability on predicted flow is small. Cell-to-cell variability is not necessary to capture flow in reservoir models; rather, it is the spatially correlated variability in petrophysical properties that is important. Reservoir modelling effort should focus on capturing correlated geologic domains in the most realistic and computationally efficient manner.