History of Bone Grafts in Spine Surgery

Hampel, Gilad A; Yılmaz, Emre; Massrey, Chrissie; Clifton, William; Iwanaga, Joe; Loukas, Marios; Tubbs, R. Shane

doi:10.7759/cureus.24655

Cited by 6 publications

(5 citation statements)

References 49 publications

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“…Bone tissue grafting is the second most commonly performed transplant procedure worldwide, with more than half a million people in the United States (USA) receiving transplants each year, second only to blood transfusion [34]. Since 1821, when Philip Walter performed the first autogenous bone transplant [35], it is still considered the gold standard for rehabilitating patients with dental problems who need reconstruction in regions of maxillofacial defects [16,36,37]. However, technology has evolved and modernized treatments in the field of oral rehabilitation, and today, the dental industry offers ways of reconstructing areas of extensive bone loss without causing harm to patients, such as bone grafting surgeries with synthetic materials that offer no risk to the patient [11,15,38,39].…”

Section: Discussionmentioning

confidence: 99%

Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

Frigério,

de Moura,

Pitol-Palin

et al. 2024

Biomimetics

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The purpose of this study was to evaluate the repair process in rat calvaria filled with synthetic biphasic bioceramics (Plenum® Osshp-70:30, HA:βTCP) or autogenous bone, covered with a polydioxanone membrane (PDO). A total of 48 rats were divided into two groups (n = 24): particulate autogenous bone + Plenum® Guide (AUTOPT+PG) or Plenum® Osshp + Plenum® Guide (PO+PG). A defect was created in the calvaria, filled with the grafts, and covered with a PDO membrane, and euthanasia took place at 7, 30, and 60 days. Micro-CT showed no statistical difference between the groups, but there was an increase in bone volume (56.26%), the number of trabeculae (2.76 mm), and intersection surface (26.76 mm2) and a decrease in total porosity (43.79%) in the PO+PG group, as well as higher values for the daily mineral apposition rate (7.16 µm/day). Histometric analysis presented material replacement and increased bone formation at 30 days compared to 7 days in both groups. Immunostaining showed a similar pattern between the groups, with an increase in proteins related to bone remodeling and formation. In conclusion, Plenum® Osshp + Plenum® Guide showed similar and sometimes superior results when compared to autogenous bone, making it a competent option as a bone substitute.

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Section: Discussionmentioning

confidence: 99%

Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

Frigério,

de Moura,

Pitol-Palin

et al. 2024

Biomimetics

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“…There is a deep history of clinical use of structural bone allografts in orthopedics, dating back to the late 19th century [18,19]. As clinical demand and usage increased, the need for dedicated allograft repositories arose; by the 1940s, bone banks were established.…”

Section: Historical Perspectivementioning

confidence: 99%

Comparative Evaluation of Mineralized Bone Allografts for Spinal Fusion Surgery

Hubbell¹,

Roth

Block³

2023

JFB

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The primary objective of this review is to evaluate whether the degree of processing and the clinical utility of commercially available mineralized bone allografts for spine surgery meet the 2020 US Food and Drug Administration’s (FDA) guideline definitions for minimal manipulation and homologous use, respectively. We also assessed the consistency of performance of these products by examining the comparative postoperative radiographic fusion rates following spine surgery. Based on the FDA’s criteria for determining whether a structural allograft averts regulatory oversight and classification as a drug/device/biologic, mineralized bone allografts were judged to meet the Agency’s definitional descriptions for minimal manipulation and homologous use when complying with the American Association of Tissue Banks’ (AATB) accredited guidelines for bone allograft harvesting, processing, storing and transplanting. Thus, these products do not require FDA medical device clearance. Radiographic fusion rates achieved with mineralized bone allografts were uniformly high (>85%) across three published systematic reviews. Little variation was found in the fusion rates irrespective of anatomical location, allograft geometry, dimensions or indication, and in most cases, the rates were similar to those for autologous bone alone. Continued utilization of mineralized bone allografts should be encouraged across all spine surgery applications where supplemental grafts and/or segmental stability are required to support mechanically solid arthrodeses.

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“…Biomaterial grafts are important in the fields of medicine and dentistry, and are mainly indicated for the reconstruction of bone tissue in areas of accentuated loss, due to the consequent impairment of function, morphology and registration of biological tissues [18][19][20][21]. There is a wide variety of graft materials, such as autogenous (from the recipient itself), homogeneous (from another non-recipient individual, of the same species), heterogeneous (from other species) and allogeneic (from tissues, but not living) [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

Vigliar,

Marega,

Duarte

et al. 2024

Bioengineering

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Biomaterials are used extensively in graft procedures to correct bone defects, interacting with the body without causing adverse reactions. The aim of this pre-clinical study was to analyze the effects of photobiomodulation therapy (PBM) with the use of a low-level laser in the repair process of bone defects filled with inorganic matrix (IM) associated with heterologous fibrin biopolymer (FB). A circular osteotomy of 4 mm in the left tibia was performed in 30 Wistar male adult rats who were randomly divided into three groups: G1 = IM + PBM, G2 = IM + FB and G3 = IM + FB + PBM. PBM was applied at the time of the experimental surgery and three times a week, on alternate days, until euthanasia, with 830 nm wavelength, in two points of the operated site. Five animals from each group were euthanized 14 and 42 days after surgery. In the histomorphometric analysis, the percentage of neoformed bone tissue in G3 (28.4% ± 2.3%) was higher in relation to G1 (24.1% ± 2.91%) and G2 (22.2% ± 3.11%) at 14 days and at 42 days, the percentage in G3 (35.1% ± 2.55%) was also higher in relation to G1 (30.1% ± 2.9%) and G2 (31.8% ± 3.12%). In the analysis of the birefringence of collagen fibers, G3 showed a predominance of birefringence between greenish-yellow in the neoformed bone tissue after 42 days, differing from the other groups with a greater presence of red-orange fibers. Immunohistochemically, in all experimental groups, it was possible to observe immunostaining for osteocalcin (OCN) near the bone surface of the margins of the surgical defect and tartrate-resistant acid phosphatase (TRAP) bordering the newly formed bone tissue. Therefore, laser photobiomodulation therapy contributed to improving the bone repair process in tibial defects filled with bovine biomaterial associated with fibrin biopolymer derived from snake venom.

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History of Bone Grafts in Spine Surgery

Cited by 6 publications

References 49 publications

Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

Comparative Evaluation of Mineralized Bone Allografts for Spinal Fusion Surgery

Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer

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