History of Chromatography

Weil, Herbert; Willams, Trevor I.

doi:10.1038/1661000b0

Cited by 23 publications

(3 citation statements)

References 3 publications

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“…Petroleum might include over 100,000 constituents. The human body is considered to have on the order of 100,000 distinct proteins [45]. Natural items, such as essential oils, are frequently complicated as well.…”

Section: Gas Chromatographymentioning

confidence: 99%

An Overview- Advances in Chromatographic Techniques in Phytochemistry

Vij,

Pathania

2023

E3S Web Conf.

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The basic idea of the Chromatographic process is that the distinct compounds have different properties like solubility, adsorption, ion exchange, and affinity that can be regulated through various separation mechanisms causing the analytes to travel through the stationary phase at different speeds, resulting in their separation from a complex mixture. The Chromatographic techniques have been explored as multidimensional, which has been growing and evolving due to continuous advancements in technology allowing it to meet the upcoming challenges and analytical demands in various scientific scenarios including academics and industries. Phytochemistry is one of the oldest core areas of research in science where one of the major challenges in drug discovery from natural sources is the identification and isolation of closely related active molecules within these complex to the observed biological activities therefore there is utmost need to better understand their intrinsic complexity and exploit their vast commercial potential. Nowadays the hyphenated techniques with one component as the chromatographic technique have been widely explored as inevitable analytical tools for early detection and identification of bioactive compounds and driving forces in the evolution and discoveries in phytochemistry from crude plant extracts that boosted mainly due to rapid technological advancements in instrumentation. It’s also significant as an intellectual method for phytotherapeutic quality control and regulation. In the present review, we have discussed the advances and insight of chromatographic techniques which can be explored for comprehensive chemical profiles of herbal medicine preparations or extracts in phytochemistry. The review provides a systematic update of the recent advancement and published approaches to methodology in phytochemistry.

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Section: Gas Chromatographymentioning

confidence: 99%

An Overview- Advances in Chromatographic Techniques in Phytochemistry

Vij,

Pathania

2023

E3S Web Conf.

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“…although they can be used to evaluate samples from ex vivo and in vivo studies. Chromatography is a century-old technique [36] used to separate and quantify complex mixtures of molecules according to their properties, which can be classified in different types (e.g. liquid chromatography, gas chromatography, ionexchange chromatography, and affinity chromatography) [37][38][39].…”

Section: In Vitromentioning

confidence: 99%

Research Models in Biomedical Sciences: Advantages and Limitations

Mb¹

2020

OAJBS

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Research models are routinely used in the biomedical field when we are talking about assays. All these models have advantages and limitations and should be chosen carefully, to avoid, mainly, mistakes in ethical practices. However, it is a great challenge for researchers picking and classifying their experimental models due to the lack of clear literature definition or guidelines. Here, we pioneer describe the overall definition of the main research models and give a gamut of examples from the biomedical field. This review also provides recommendations for aligning experimental practices to meet the necessity of assessing an international research model classification.

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“…Many recent reports (96,367,368,384) indicate that the differential migration of solutes through porous media was known long before Tswett described his extensive chromatographic separation of leaf pigments in 1906. These early observations on the absorption of ions by soils (198), on the decolorization of solutions, and on the filtration of petroleum revealed that the filtration of a solution through an absorptive medium retarded the migration of the solutes, but this filtration method did not provide a resolution of complex mixtures of solutes.…”

Section: Evolution Of Chromatographymentioning

confidence: 99%