History of Depression in Lung Cancer Patients: Impact of Delay

Iachina, Maria; Brønserud, Majken M.; Jakobsen, Erik; Trosko, Oleg; Green, A.

doi:10.1016/j.clon.2017.03.014

Cited by 9 publications

(15 citation statements)

References 15 publications

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“…Although cancer incidence in psychiatric patients is similar to that in the general population psychiatric disorders may have a negative impact on the prognosis of cancer [ 1 – 8 ]. However, psychiatric disorders may affect the advocating or acceptance of cancer diagnostic procedures or treatment as suggested for lung cancer patients [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

et al. 2018

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BackgroundPsychiatric patients with colorectal cancer may have delayed diagnosis and be oncologically undertreated.MethodsThe Danish Colorectal Cancer Group database comprised 25,194 colorectal cancer patients (CRC), (colon cancer (CC, n = 16,641), rectal cancer (RC, n = 8553)), having an operation in 2007–2013, were alive at least 30 days after operation, of which 422 have had at least one hospital contact for a serious psychiatric disorder; ICD-10: DF20–29: primary psychotic disorders, or DF30–39: affective disorders (exposed) in a period of 3650–120 days before the operation date. Pearson chi-squared test for cancer stage was calculated. Odds Ratio (OR) with 95% confidence interval (CI) for having had a palliative vs an intended curative aim of the operative treatment for CRC patients (cohort 1), and for having an oncological treatment for each cancer site CC or RC (cohort 2 and 3) in patients with and without a psychiatric history was estimated. We adjusted the OR for: age, gender, comorbidity index, cancer stage, socio-economic position group, and educational level.ResultsA higher cancer stage at the time of operation in patients with psychiatric disorders compared with patients without such a history was seen and may possibly point towards a delay in the diagnosis or in the treatment of CC in patients with psychiatric disorders. They also had decreased adjusted OR for having an oncological treatment, OR 0.55, 95% CI (0.40–0.76)), which was not explained by cancer stage. For patients with RC no difference was seen.ConclusionsAttention for CC patients with pre-existing serious psychiatric disorders is recommended.

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Section: Introductionmentioning

confidence: 99%

Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

et al. 2018

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“…We assessed the quality of studies included in the review using the NOS (See methods). 17/29 of the studies were judged to be of high quality, 15,16,19,20,22,[24][25][26][27]29,[32][33][34][37][38][39]41 10/29 of medium quality, 18,23,28,30,31,35,36,40,42,43 and 2/29 of low quality (Table 3). 17,21 Most studies adjusted for patients' demographic characteristics (age, sex, socio-economic status, and race/ethnicity) and disease characteristics (cancer stage, cancer diagnosis method, tumor size, and comorbidity).…”

Section: Results Robustnessmentioning

confidence: 99%

Impact of pre‐existing mental health disorders on the receipt of guideline recommended cancer treatments: A systematic review

et al. 2023

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Objective: Disparities in cancer outcomes for individuals with pre-existing mental health disorders have already been identified, particularly for cancer screening and mortality. We aimed to systematically review the influence on the time from cancer diagnosis to cancer treatment, treatment adherence, and differences in receipt of guideline recommended cancer treatment. Methods:We included international studies published in English from 1 January 1995 to 23 May 2022 by searching MEDLINE, Embase, and APA PsycInfo.Results: This review identified 29 studies with 27 being published in the past decade. Most studies focused on breast, non-small cell lung and colorectal cancer and were of high or medium quality as assessed by the Newcastle Ottawa Scale. All studies were from high-income countries, and mostly included patients enrolled in national health insurance systems. Five assessed the impact on treatment delay or adherence, and 25 focused on the receipt of guideline recommended treatment. 20/ 25 studies demonstrated evidence that patients with pre-existing mental health disorders were less likely to receive guideline recommended therapies such as surgery or radiotherapy. In addition, there was a greater likelihood of receiving less intensive or modified treatment including systemic therapy.Conclusions: Across different cancer types and treatment modalities there is evidence of a clear disparity in the receipt of guideline recommended cancer treatment for patients with pre-existing mental health disorders. The effect of pre-existing mental health disorders on treatment delay or adherence is under-researched.Future research needs to include low-and middle-income countries as well as qualitative investigations to understand the reasons for disparities in cancer treatment.

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“…Other studies have shown that patients with both cancer and psychiatric disorders have a lower chance of receiving oncological treatment compared to patients with cancer without psychiatric disorders (28,29). Results from the present study indicate the same tendency for patients with cervix cancer.…”

Section: Discussionmentioning

confidence: 99%

Influence of Prior Psychiatric Disorders on the Treatment Course of Gynaecological Cancer – A Nationwide Cohort Study

et al. 2019

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Objectives: To examine the influence of pre-existing psychiatric disorder on the choice of treatment in patients with gynecological cancer. Materials and methods: The analyses are based on all patients who underwent surgical treatment for endometrial, ovarian or cervical cancer who were registered in the Danish Gynecological Cancer Database in the years 2007-2014 (3,059 patients with ovarian cancer, 5,100 patients with endometrial cancer, and 1,150 with cervical cancer). Logistic regression model and Cox regression model, adjusted for relevant confounders, were used to estimate the effect of pre-existing psychiatric disorder on the course of cancer treatment. Our outcomes were i) pre-surgical oncological treatment, ii) macroradical surgery for patients with ovarian cancer, iii) radiation/chemotherapy within 30 days and 100 days after surgery, and iv) time from surgery to first oncological treatment. Results: In the group of patients with ovarian cancer, more patients with a psychiatric disorder received macro-radical surgery vs patients without a psychiatric disorder, corresponding to an adjusted OR of 1.24 (95% CI 0.62-2.41), and the chance for having oncological treatment within 100 days was OR=1.26 (95% CI 0.77-2.10). AS for patients with endometrial cancer, all outcomeestimates were close to unity. The adjusted OR for oncological treatment within 30 days after surgery in patients with cervix cancer with a history of psychiatric disorder was 0.20 (95% CI 0.03-1.54). Conclusions: We did not find any significant differences in the treatment of ovarian and endometrial cancer in patients with pre-existing psychiatric diagnoses. When it comes to oncological treatment, we suggest that an increased attention should be paid to patients with cervix cancer having a pre-existing psychiatric diagnosis.

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History of Depression in Lung Cancer Patients: Impact of Delay

Cited by 9 publications

References 15 publications

Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

Impact of pre‐existing mental health disorders on the receipt of guideline recommended cancer treatments: A systematic review

Influence of Prior Psychiatric Disorders on the Treatment Course of Gynaecological Cancer – A Nationwide Cohort Study

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