History of endometriosis may adversely affect the outcome in menopausal recipients of sibling oocytes

Prapas, Yannis; Goudakou, Maria; Matalliotakis, Ioannis; Kalogeraki, Alexandra; Matalliotaki, Charikleia; Panagiotidis, Yannis; Ravanos, Konstantinos; Prapas, Nikos

doi:10.1016/j.rbmo.2012.07.020

Cited by 48 publications

(49 citation statements)

References 36 publications

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“…Sharing sibling oocytes with the controls from donors documented not to harbor endometriosis, recipients with stage III-IV endometriosis (n = 25) were reported to have comparable pregnancy rates to controls (n = 33) without endometriosis [40]. In contrast, using a similar study design, with a larger sample size of 240 patients, lower implantation, clinical and live birth rates were reported in menopausal recipients with endometriosis compared to the controls [41]. In our study, we noted comparable implantation rates among the early- and late-stage disease and control groups refuting any detrimental effect of endometriosis on embryo viability and/or endometrial receptivity.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Polat¹,

Boynukalın²,

Yaralı³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To analyze whether the presence of endometriosis per se is associated with inferior pregnancy rates in women undergoing in vitro fertilization (IVF). Methods: Between July 2005 and November 2012, a total of 485 patients with endometriosis under the age of 38 years undergoing their first IVF attempt at our center were included; 72 patients had minimal-mild disease and the remaining 413 patients had moderate-severe disease. 131 patients with laparoscopically confirmed tubal factor infertility not harboring endometriosis and hydrosalpinx under the age of 38 years undergoing their first IVF attempt at our center served as the control group. Results: The bilateral antral follicle count and controlled ovarian hyperstimulation response were diminished in the moderate-severe group. However, the implantation, clinical pregnancy, miscarriage and live birth rates were comparable among the three groups. The recurrence of endometrioma following pre-IVF cystectomy was not associated with inferior pregnancy rates. Female age, bilateral antral follicle count and number of embryos transferred were noted to be significant independent predictors of live birth. Conclusion: We conclude that neither the presence nor the extent of endometriosis have any detrimental effect on IVF pregnancy rates.

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Section: Discussionmentioning

confidence: 99%

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Polat¹,

Boynukalın²,

Yaralı³

et al. 2014

Gynecol Obstet Invest

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show abstract

“…Studies from In Vitro Fertilization (IVF) cycles have documented a decreased pregnancy rate (24, 25), which can be improved with gonadotropin releasing hormone agonist (GnRHa) suppression (26), surgery (27) or aromatase inhibitor therapy (28). While early studies on donor oocytes has suggested the primary defect associated with endometriosis may reside in the ovary and oocyte quality (29), larger and more recent studies have documented that defective implantation is also likely involved (30). Prapas and co-workers studied the result of 240 cycles, placing sibling oocytes from the same donor into women with or without endometriosis.…”

Section: Endometriosis and Infertility – What Is The Evidence?mentioning

confidence: 99%

“…Prapas and co-workers studied the result of 240 cycles, placing sibling oocytes from the same donor into women with or without endometriosis. Adjusted odds ratio (95% CI) showed reduced implantation (0.78 (0.67-0.91)), clinical pregnancy rate (0.22 (0.08-0.57)), ongoing pregnancy (0.11 (0.03-0.35)), and live birth rate (0.19 (0.09-0.38)) for women with endometriosis (30). …”

Section: Endometriosis and Infertility – What Is The Evidence?mentioning

confidence: 99%

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Lessey¹,

Kim²

2017

Fertility and Sterility

221

158

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The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation, creates the opportunity in the setting of endometriosis for the establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggests that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis.

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“…Several clinical studies have indicated a decreased implantation rate in endometriosis patients undergoing IVF [73,74,75], and a meta-analysis of 27 studies demonstrated significantly lower implantation and clinical pregnancy rates in patients with severe endometriosis [76]. To exclude factors associated with oocyte and embryo quality, a prospective study using sibling oocytes from the same donor demonstrated that recipients with endometriosis had significantly lower implantation and pregnancy rates than control recipients [77]. However, not all related studies have reached the same conclusion, instead generally attributing poorer IVF outcome in endometriosis patients to compromised oocyte and embryo quality [78,79,80,81].…”

Section: Chronic Niche Inflammation In Endometriosis Developmentmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.

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History of endometriosis may adversely affect the outcome in menopausal recipients of sibling oocytes

Cited by 48 publications

References 36 publications

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Endometriosis Is Not Associated with Inferior Pregnancy Rates in in vitro Fertilization: An Analysis of 616 Patients

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

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