History of gastroesophageal reflux disease in patients with suspected coronary artery disease

Teragawa, Hiroki; Oshita, Chikage; Ueda, Toshihisa

doi:10.1007/s00380-019-01413-1

Cited by 24 publications

(32 citation statements)

References 29 publications

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“…There was no racial difference about coronary spasm according to the report of Ong et al and ours [7,8]. Recently, Teragawa et al reported that medical history of GERD was frequently observed in approximately onefifth of patients with coronary spastic angina [9]. Furthermore, GERD is associated with an increased risk of developing coronary heart disease [10].…”

Section: Necessity Of Differential Diagnosis Of Coronary Spasm For Gerdmentioning

confidence: 57%

General internists of experience suspected variant angina as gastroesophageal reflux diseases in two cases: Heart burn may be related to coronary spasm

Sueda

2020

Journal of Cardiology Cases

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General physicians of experience suspected variant angina as gastroesophageal reflux disease (GERD) due to heart burn in two patients. Proton pump inhibitors were administered in these patients, although spontaneous ST segment elevations were recognized and total or subtotal coronary spasm was provoked by the pharmacological spasm provocation tests. Under the vasodilators but not proton pump inhibitors, two patients complained of neither heart burn nor chest symptoms. General internists and cardiologists should bear in mind coronary spasm when they suspect GERD due to heart burn. Guidelines for GERD may note the necessity of differential diagnosis of coronary artery spasm as one of etiology of GERDrelated chest symptoms.

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Section: Necessity Of Differential Diagnosis Of Coronary Spasm For Gerdmentioning

confidence: 57%

General internists of experience suspected variant angina as gastroesophageal reflux diseases in two cases: Heart burn may be related to coronary spasm

Sueda

2020

Journal of Cardiology Cases

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“…An SPT was performed using the methods described previously[ 5 ]. In brief, after the initial coronary angiogram (CAG), 20 and 50 μg doses of acetylcholine (ACh) were injected into the RCA.…”

Section: Methodsmentioning

confidence: 99%

“…We adopted the use of an autoinjector as described previously[ 5 ]. When unstable hemodynamics continued, small doses of intracoronary or intravenous catecholamines were infused.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, low doses of ACh (L-ACh) were considered to be 20 μg for the RCA and 50 μg for the LCA. The diameters of the coronary artery were measured as described previously[ 5 ]. Lesions with > 20% stenosis were defined as atherosclerotic lesions.…”

Section: Methodsmentioning

confidence: 99%

“…The patient was asked about his or her current smoking status, and any family history of coronary artery disease (FH-CAD) was recorded. Hypertension, dyslipidemia, diabetes mellitus and chronic kidney disease were defined based on the standard definitions described in previous papers[ 5 ]. A patient was defined as an alcohol drinker if he or she consumed alcohol one or more times a week.…”

Section: Methodsmentioning

confidence: 99%

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Clinical significance of prolonged chest pain in vasospastic angina

Teragawa¹,

Oshita²,

Orita³

2020

WJC

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BACKGROUND Patients with vasospastic angina (VSA) sometimes experience prolonged chest symptoms. The clinical characteristics of these patients have not been clarified. AIM To investigate the clinical characteristics of prolonged VSA patients. METHODS This study included 167 patients with VSA diagnosed by spasm provocation tests (SPTs) using acetylcholine, which recorded the frequencies of positive reactions to a low dose of acetylcholine (L-ACh), total occlusion due to spasm (TOC), focal spasm, and the unavoidable use of nitroglycerin (unavoidable-NTG) during SPTs. The patients underwent a medical interview that investigated the maximum duration and frequency of chest symptoms as well as the frequencies of variant angina and other serious symptoms. The patients were divided into two groups based on the maximal duration: The short-duration group (< 15 min; n = 114) and the long-duration group (≥ 15 min; n = 53). They were also divided into two groups based on the frequency of chest symptoms: The low-frequency group (< 4/mo; n = 88) and the high-frequency group (≥ 4/mo; n = 79). RESULTS The long-duration group showed higher frequencies of other serious symptoms ( P < 0.001) and variant angina ( P < 0.05) as well as higher frequencies of spasm induction by L-ACh ( P < 0.05), TOC ( P < 0.05), focal spasm ( P < 0.01), and unavoidable-NTG ( P < 0.01) than the short-duration group. These parameters did not differ significantly between the low-frequency and high-frequency groups. CONCLUSION These findings suggest that patients with VSA who experience prolonged chest symptoms may have more severe characteristics of VSA.

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History of gastroesophageal reflux disease in patients with suspected coronary artery disease

Cited by 24 publications

References 29 publications

General internists of experience suspected variant angina as gastroesophageal reflux diseases in two cases: Heart burn may be related to coronary spasm

General internists of experience suspected variant angina as gastroesophageal reflux diseases in two cases: Heart burn may be related to coronary spasm

Clinical significance of prolonged chest pain in vasospastic angina

Acute myocardial infarction followed by radiofrequency therapy for gastroesophageal reflux disease in a man: A case report

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