History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies

Muthuri, Stella G.; McWilliams, Daniel F.; Doherty, Michael; Zhang, Weiya

doi:10.1016/j.joca.2011.07.015

Cited by 227 publications

(180 citation statements)

References 46 publications

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“…Some studies have used similar definitions to ours including non-weight bearing as a criteria for a significant knee injury; however, the duration of non-weight bearing seems variable across studies. Other studies have used outcomes such as duration of pain after the injury as a criterion for a significant injury [16]. Therefore, our definition may have affected our findings; nonetheless, we have demonstrated biologically plausible associations in both cohorts.…”

Section: Discussionmentioning

confidence: 91%

“…Firstly, it is not clear whether the injury to the knee joint or the subsequent surgery leads to the development of secondary OA, as the available literature often refers to knee trauma without a clear distinction between the two [15,16]. Secondly, it is not known which structures comprising the knee joint, as determined by MRI, are affected by injury and hence contribute towards the progression of the disease process.…”

Section: Introductionmentioning

confidence: 99%

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History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

et al. 2014

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The aim of this cross-sectional study was to describe the associations between history of knee injury and knee structure using magnetic resonance imaging (MRI). This study included two population-based samples: the Tasmanian Older Adult Cohort (TASOAC) study (n = 430; mean age, 63.0 years; range, 51-79 years; 51 % female) and the Offspring study (n = 372; mean age, 45.0 years; range, 26-61 years; 57.5 % female). In both studies, 1.5 T MRI scans of the right knee were performed to measure bone marrow lesions (BMLs), cartilage volume, tibial bone area, cartilage defects and meniscal pathology. History of knee injury was assessed using a self-administered questionnaire. The association between knee injury and knee structure was determined using multiple linear and log binomial regression models. Nineteen percent of the middle-aged and 12 % of the older adults reported a history of knee injury. In middle-aged adults, BML presence (prevalence ratio (PR) = 1.6 (95 % CI, 1.2; 2.1)), tibial bone area (difference of means (DM) = +86 (+23, +149)) and meniscal extrusion presence (PR = 2.7 (1.1, 6.8)) were significantly higher in those with knee injury. In older adults, cartilage defect presence (PR = 1.3 (1.0, 1.7)), lateral (DM = -265 (-439, -92)) and total tibial (DM = -325 (-600, -51)) cartilage volume, BML presence (PR = 1.4 (1.0, 1.9)) and tibial bone area (DM = +140 (+19, +260)) were significantly associated with knee injury. Meniscal tears showed no significant associations in either cohorts. The association between knee injury and MRI-assessed structural pathology in the knee joint is moderate and appears to be stronger in older adults compared to middle-aged adults.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

et al. 2014

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“…Persons who sustain a knee injury are 4.2 times more likely to develop OA than those without a history of knee injury. 9 Authors 3 of a retrospective medical record review suggested that PTOA accounts for approximately 10% of all cases of knee OA.…”

Section: Incidence and Prevalence Of Oamentioning

confidence: 99%

Epidemiology of Posttraumatic Osteoarthritis

Thomas

Hubbard-Turner

Wikstrom

et al. 2017

Journal of Athletic Training

280

199

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Osteoarthritis is a leading cause of disability whose prevalence and incidence continue to increase. History of joint injury represents an important risk factor for posttraumatic osteoarthritis and is a significant contributor to the rapidly growing percentage of the population with osteoarthritis. This review will present the epidemiology associated with posttraumatic osteoarthritis, with particular emphasis on the knee and ankle joints. It is important to understand the effect of posttraumatic osteoarthritis on the population so that sufficient resources can be devoted to countering the disease and promoting optimal long-term health for patients after joint injury.

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“…1 A systematic review found that patients with a previous history of traumatic knee injury are at increased risk of developing knee OA, regardless of specific injury. 2 It is vital for the maintenance of quality of life for individuals affected with OA that the treatment options available be able to reduce symptoms and restore quality of living. The painrelief benefits of traditional injection treatments are small to moderate and have a limited duration.…”

Section: Clinical Scenariomentioning

confidence: 99%

The Effectiveness of Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis

Astolfi

McGuire²,

Kaminski³

2014

Journal of Sport Rehabilitation

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Clinical Scenario: Osteoarthritis (OA) is a debilitating degenerative disease affecting an estimated 27 million Americans. A systematic review found that patients with a previous history of traumatic knee injury are at increased risk of developing knee OA, regardless of specific injury. It is vital for the maintenance of quality of life for individuals affected with OA that the treatment options available be able to reduce symptoms and restore quality of living. The pain-relief benefits of traditional injection treatments are small to moderate and have a limited duration. It was found that at 2 wk postinjection that corticosteroids were more effective than hyaluronic acid (HA) injections. Autologous conditioned serum (ACS) injection is a novel treatment that has shown favorable results. However, many clinicians continue to use HA injections for reduction of symptoms in patients with osteoarthritis when the use of ACS may be more beneficial. Focused Clinical Question: For patients with knee OA, is an ACS injection more efficient at producing a reduction in symptoms than HA or a saline injection?Keywords: injections, Orthokine, hyaluronic acid, rheumatoid arthritis Clinical ScenarioOsteoarthritis (OA) is a debilitating degenerative disease affecting an estimated 27 million Americans. 1 A systematic review found that patients with a previous history of traumatic knee injury are at increased risk of developing knee OA, regardless of specific injury. 2 It is vital for the maintenance of quality of life for individuals affected with OA that the treatment options available be able to reduce symptoms and restore quality of living. The painrelief benefits of traditional injection treatments are small to moderate and have a limited duration. Bannuru et al 3 found that at 2 weeks postinjection that corticosteroids were more effective than hyaluronic acid (HA) injections. 3 Autologous conditioned serum (ACS) injection is a novel treatment that has shown favorable results. However, many clinicians continue to use HA injections for reduction of symptoms in patients with osteoarthritis when the use of ACS may be more beneficial. Focused Clinical QuestionFor patients with knee OA, is an ACS injection more efficient at producing a reduction in symptoms than HA or a saline injection?Summary of Search, "Best Evidence" Appraised, and Key Findings• We searched the literature for studies that investigated the effects of ACS on OA.• Three studies were included. [4][5][6] • Two studies 5,6 were randomized control trials, which used subjective measures from the patients to determine effects of ACS in the reduction of symptoms. Both studies found that ACS injections showed greater improvement than HA and saline injections.• The final study that was included, also a randomized control trial, was a major translational study that examined the efficacy of ACS in the treatment of surgically induced OA in horses and found a significant improvement in lameness scores compared with the placebo treatment. 4

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History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies

Abstract: History of knee injury is a major risk factor for the development of knee OA irrespective of study design and definition of knee injury. As one of the few modifiable/preventable risk factors, knee injury should be part of the future prevention programme in reducing the risk of knee OA.

Cited by 227 publications

References 46 publications

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

Epidemiology of Posttraumatic Osteoarthritis

The Effectiveness of Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis

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