History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China

HosgoodIII, H. Dean; Chapman, Robert S.; He, Xingzhou; Hu, Wei; Tian, Linwei; Liu, Larry Z.; Li, Hong; Chen, Wei; Rothman, Nathaniel; Lan, Qing

doi:10.1016/j.lungcan.2013.06.019

Cited by 23 publications

(16 citation statements)

References 19 publications

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“…Interestingly, pneumonia was associated with lung cancer among never smokers [Brenner et al, ]. The associations between nonmalignant lung diseases, specifically TB, COPD, and chronic bronchitis, and the risk of lung cancer have also been reported in Xuanwei, China [Hosgood et al, ]. This suggests that the etiologic link between the pathogens enriched in our cases (i.e., Granulicatella, Streptococcus) and lung cancer is potentially driven by chronic inflammation of the lung.…”

Section: Discussionsupporting

confidence: 59%

The potential role of lung microbiota in lung cancer attributed to household coal burning exposures

Hosgood

Sapkota

Rothman

et al. 2014

Environ and Mol Mutagen

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175

139

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Bacteria influence site-specific disease etiology and the host’s ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs). Lung cancer in Xuanwei, China has been attributed to PAH-rich household air pollution from burning coal. This study seeks to explore the role of lung microbiota in lung cancer among never smoking Xuanwei women and how coal burning may influence these associations. DNA from sputum and buccal samples of never smoking lung cancer cases (n = 8, in duplicate) and controls (n = 8, in duplicate) in two Xuanwei villages was extracted using a multi-step enzymatic and physical lysis, followed by a standardized clean-up. V1–V2 regions of 16S rRNA genes were PCR-amplified. Purified amplicons were sequenced by 454 FLX Titanium pyrosequencing and high-quality sequences were evaluated for diversity and taxonomic membership. Bacterial diversity among cases and controls was similar in buccal samples (P = 0.46), but significantly different in sputum samples (P = 0.038). In sputum, Granulicatella (6.1 vs. 2.0%; P = 0.0016), Abiotrophia (1.5 vs. 0.085%; P = 0.0036), and Streptococcus (40.1 vs. 19.8%; P = 0.0142) were enriched in cases compared with controls. Sputum samples had on average 488.25 species-level OTUs in the flora of cases who used smoky coal (PAHrich) compared with 352.5 OTUs among cases who used smokeless coal (PAH-poor; P = 0.047). These differences were explained by the Bacilli species (Streptococcus infantis and Streptococcus anginosus). Our small study suggests that never smoking lung cancer cases have differing sputum microbiota than controls.

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Section: Discussionsupporting

confidence: 59%

The potential role of lung microbiota in lung cancer attributed to household coal burning exposures

Hosgood

Sapkota

Rothman

et al. 2014

Environ and Mol Mutagen

Self Cite

175

139

View full text Add to dashboard Cite

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“…The incidence of lung cancer in many Asian countries has risen in response to multiple risk factors, including cigarette smoking, air pollution, and use of coal and biomass fuels. [40][41][42][43] The smoking epidemic in many Asian countries, in contrast to the situation in many Western countries, has only just peaked or is still rising and continues to represent a key risk factor for lung cancer. 44,45 In China, smoking rates among men were estimated at 52.9% in 2010.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Pulmonary Nodules

Bai

Choi

Chu

et al. 2016

Chest

171

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“…Because the majority of households in developing countries rely on solid fuels for daily cooking and heating needs, there are growing concerns over air pollution from solid fuel combustion and the associated health problems [4][5][6][7]. The most recent Global Burden of Disease study (2010) estimated that the exposure to smoke from household air pollution was responsible for approximately 3.5 million premature deaths globally, as well as other various health issues, such as cataracts and cardiovascular disease [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Household fuel use for cooking and heating in China: Results from the first Chinese Environmental Exposure-Related Human Activity Patterns Survey (CEERHAPS)

et al. 2014

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h i g h l i g h t sThe first CEERHAPS survey obtained firsthand data on household fuel use in China. Solid fuel are widely used for cooking and heating, with large spatial variances. Statistically negative correlation between the income and solid fuel use fraction. Models for household fuel use estimation at national and provincial levels. The proportion of solid fuel use decreased during the last two decades. Household fuel-use (HFU) patterns are strongly associated with multiple effects, including air quality, human health, and regional climate change. This paper presents the results from the first Chinese Environmental Exposure-Related Human Activity Patterns Survey (CEERHAPS), carried out among 91,121 households located in 9108 villages, 636 towns, and 159 counties in 31 provinces. Face-to-face interviews were conducted with each participant to obtain information about the type of fuels used for cooking and heating. The main objectives of this paper were to investigate HFU for cooking and heating in China, to validate the World Health Organization (WHO) model, and to help inform local evaluation models. In China, gas and biomass fuels, the dominant energy fuels for cooking, are used by 44.8% and 32.1% of households, respectively. Approximately 34.1% of families have no household heating during the cold season, and 16.7%, 15.6% and 12.8% of households rely on coal, electricity, and biomass, respectively, for household heating when no central heating was available. The proportion of households using solid fuels has generally decreased during the last two decades. Considerable spatial variation was evident in the HFU patterns for both cooking and heating. The data revealed that the predominant fuel for cooking was biomass (47.6%) in rural populations, whereas urban households were more likely to cook with gas (65.8%). In terms of heating, coal (21.4%) and biomass (19.0%) were the main fuels used in rural households, while electricity (23.6%) and coal (10.5%) were more commonly used in urban areas. The overall HFU results for cooking from this study were comparable to those predicted using the WHO model. We also developed models at the provincial level to estimate HFU for cooking and heating in China; it is expected that the model, if confirmed by future studies, could be used for future research on household air pollution, domestic human exposure and burden of disease.

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History of lung disease and risk of lung cancer in a population with high household fuel combustion exposures in rural China

Cited by 23 publications

References 19 publications

The potential role of lung microbiota in lung cancer attributed to household coal burning exposures

The potential role of lung microbiota in lung cancer attributed to household coal burning exposures

Evaluation of Pulmonary Nodules

Household fuel use for cooking and heating in China: Results from the first Chinese Environmental Exposure-Related Human Activity Patterns Survey (CEERHAPS)

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