History of Migraine and Risk of COVID-19: A Cohort Study

Rist, Pamela M.; Buring, Julie E.; Manson, JoAnn E.; Sesso, Howard D.; Kurth, Tobias

doi:10.1016/j.amjmed.2023.07.021

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…While it has been established that patients with a history of migraine do not have a significant risk increase of developing COVID-19, the biological and immunological mechanisms underlying the effective interaction between the two disorders and their differences according to genetic variability across different countries are largely unknown [ 31 ]. The SARS-CoV-2 binding to the angiotensin-converting enzyme 2 (ACE2) binding from SARS-CoV-2 is associated with a reduced anti-inflammatory effect due to enzyme activity reduction, in favor of inflammatory headache [ 32 ].…”

Section: Environmental and Occupational Issues Based On The Example O...mentioning

confidence: 99%

Health equity, care access and quality in headache – part 1

Tana,

Raffaelli,

Souza

et al. 2024

J Headache Pain

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Current definitions of migraine that are based mainly on clinical characteristics do not account for other patient’s features such as those related to an impaired quality of life, due to loss of social life and productivity, and the differences related to the geographical distribution of the disease and cultural misconceptions which tend to underestimate migraine as a psychosocial rather than neurobiological disorder.Global differences definition, care access, and health equity for headache disorders, especially migraine are reported in this paper from a collaborative group of the editorial board members of the Journal of Headache and Pain. Other components that affect patients with migraine, in addition to the impact promoted by the migraine symptoms such as stigma and social determinants, are also reported.

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Section: Environmental and Occupational Issues Based On The Example O...mentioning

confidence: 99%

Health equity, care access and quality in headache – part 1

Tana,

Raffaelli,

Souza

et al. 2024

J Headache Pain

View full text Add to dashboard Cite

show abstract

Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk

Xu,

Chen,

et al. 2024

Sci Rep

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Migraine is a common neurological disorder observed after coronavirus disease 2019 (COVID 19) infection. However, the intricate relationship between COVID 19 and migraine, particularly the potential mediating role of brain imaging-derived phenotypes (BIPs), remains unclear. This study used linkage disequilibrium score regression (LDSC), a bidirectional two-sample Mendelian randomization (MR) approach, and two-step MR analysis to investigate potential causal links. The robustness of the MR findings was corroborated through generalized summary-data-based Mendelian randomization (GSMR) and MR-Steiger methods. The results of the LDSC analysis revealed that the genetic correlation coefficient between COVID 19 traits and migraine was 0.0277 for infection ( P = 0.0051), 0.1690 for hospitalization ( P = 0.0016), and 0.1147 for severity ( P = 0.0330). The genetic correlation coefficients between COVID 19 infection, hospitalization, severity and migraine and migraine with aura (MA) were 0.2654 ( P = 0.0012), 0.2065 ( P = 0.0043), and 0.1537 ( P = 0.0230), respectively. Two-sample MR analysis revealed a significant causal association of COVID 19 infection (odds ratio [OR] 1.2502, P = 0.0083; OR 1.4956, P = 0.0084), hospitalization (OR 1.0689, P = 0.0138; OR 1.0919, P = 0.0208), and severity (OR 1.0644, P = 0.0072; OR 1.0844, P = 0.0098) with increased risk of migraine and migraine with aura (MA). Cortical thickness (CT), total surface area (TSA), and fractional anisotropy (FA) were identified as BIP intermediaries in the risk trajectory from COVID 19 to migraine. The TSA exhibited a more pronounced mediating effect than did CT. This study revealed that genetically predicted COVID 19 is associated with an increased risk of migraine and MA, and BIPs act as potential mediators of these causal relationships, offering insights into the neurobiological underpinnings of migraine in the context of COVID 19.

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History of Migraine and Risk of COVID-19: A Cohort Study

Cited by 2 publications

References 9 publications

Health equity, care access and quality in headache – part 1

Health equity, care access and quality in headache – part 1

Brain structures as potential mediators of the causal effect of COVID 19 on migraine risk

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