History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS)

Giuli, Valeria De; Besana, Michele; Grassi, Mario; Zedde, Marialuisa; Zini, Andrea; Lodigiani, Corrado; Marcheselli, Simona; Cavallini, Anna; Micieli, Giuseppe; Rasura, Maurizia; DeLodovici, Maria Luisa; Tomelleri, Giampaolo; Checcarelli, Nicoletta; Chiti, Alberto; Giorli, Elisa; Sette, Massimo Del; Tancredi, Lucia; Toriello, Antonella; Braga, Massimiliano; Morotti, Andrea; Poli, Loris; Caria, Filomena; Gamba, Massimo; Patella, Rosalba; Spalloni, Alessandra; Simone, Anna Maria; Pascarella, Rosario; Beretta, Sandro; Fainardi, Enrico; Padovani, Alessandro; Gasparotti, Roberto; Pezzini, Alessandro

doi:10.5853/jos.2019.00332

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…Ischemic stroke (IS) is associated with high morbidity, high mortality, and high disability, which imposes a heavy burden on society and families, and its incidence has gradually increased in recent years 1,2 . When blood supply is blocked, brain tissue energy is depleted, which is the most direct cause of brain damage.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Combination of Paeoniflorin and Calycosin-7-glucoside Promotes Ischemic Stroke Recovery via the PI3K/AKT Signaling Pathway

Wang

Yan

et al. 2020

Preprint

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Background Paeoniflorin (PF) and calycosin-7-glucoside (CG) play a role in protecting against brain damage following cerebral ischemia. However, the mechanism of action of PF in combination with CG (PF + CG) against ischemia/reperfusion injury remains unclear. Methods The aim of this study was to investigate the protective role of PF + CG on ischemia/reperfusion injury in vivo and in vitro, as well as its potential mechanism of action indicating that PF + CG attenuates middle cerebral artery occlusion (MCAO) /oxygen-glucose deprivation reperfusion (OGD/R) injury via the PI3K/AKT pathway. MCAO rat model was prepared by modified suture method, and behavioral scoring, cerebral infarction area, brain tissue water content measurement, using PI3K, p-PI3K, AKT, p-AKT, Bcl-2, Bax, GSK-3β protein expression as indicators, observe the effect of PI3K / AKT signaling pathway inhibitor LY294002 on the anti-ischemia-reperfusion effect of PF + CG. Oxygen deprivation method was used to prepare the OGD/R model, CCK-8 was used to determine the survival rate of HT22 cells, the contents of SOR, ROS, MDA, and LHD were determined, and apoptosis was detected by flow cytometry and mitochondrial membrane potential, using PI3K, p-PI3K, AKT, p-AKT, Bcl-2, Bax, GSK-3β protein expression as indicators, observe the effect of PI3K/AKT signaling pathway inhibitor LY294002 on the anti- oxidative and glucose deprivation effect of PF + CG. Results The animal studies showed that PF + CG significantly decreased neurobehavioral deficits, cerebral infarct volume, and brain edema; ameliorated histopathological damage in model rats; increased levels of PI3K, AKT, p-PI3K, p-AKT, and Bcl-2; and reduced BAX and GSK-3β expression. After treatment with PF + CG, the morphology and number of cells in brain tissue were restored to normal, demonstrating a therapeutic effect in cerebral ischemia-reperfusion injury. Results of further studies revealed that, in vitro, PF + CG has a therapeutic effect to enhance cell vitality; elevate levels of superoxide dismutase (SOD); reduce levels of reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA); decrease apoptosis rate; increase levels of PI3K, AKT, p-PI3K, p-AKT, and Bcl-2; and reduce BAX and GSK-3β expression. Conclusion These results demonstrate that PF + CG has a positive therapeutic effect on ischemia/reperfusion and OGD/R injury, and the mechanism is attributed to activation of the PI3K/AKT signaling pathway.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Combination of Paeoniflorin and Calycosin-7-glucoside Promotes Ischemic Stroke Recovery via the PI3K/AKT Signaling Pathway

Wang

Yan

et al. 2020

Preprint

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“…On the one side, the unbalanced release of endothelial substances and microcirculation thrombosis can trigger cortical spreading depression (39); on the other side, frequent migraine attacks seem to interfere with endothelial functioning (26). In any case, the cerebral cortex of patients with MA seems to be particularly vulnerable to ischemic insults, displaying larger infarct volume (40) and a reduced ratio between hypoperfused and infarcted ischemic areas (41). This sensitivity to ischemic insults can result from different factors, among which the most relevant seems to be an impairment of vascular tone regulation secondary to endothelial dysfunction as an inefficient use of energy supplies (42).…”

Section: Discussionmentioning

confidence: 99%

Stroke territory and atherosclerosis in ischemic stroke patients with a history of migraine with aura

Altamura

Viticchi²,

Rizzo³

et al. 2023

Front. Neurol.

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IntroductionThe mechanisms subtending the increased stroke risk in migraine with aura (MA) are not fully understood. Our study aims to evaluate if the clinical profile in stroke patients with MA differentiates from those without MA.MethodsWe retrieved the prospective registered electronic clinical dossiers of adult patients younger than 60 years with acute ischemic stroke admitted in four hospitals between January 2016 and June 2022. Patients were classified by the history of MA (MA+ and MA–).ResultsWe identified 851 stroke patients (59 MA+, 6.9%). Compared to MA−, MA+ patients were characterized by younger age (44.0 ± 10.6 vs 50.1 ± 8.2 years), female sex (59.3% vs 29.0%), and affected by cryptogenic (OR 2.594 95% CI 1.483–4.537), and cerebellar stroke (OR 3.218 95% CI 1.657–6.250; p ≤ 0.001 for all comparisons). After adjusting for age and sex, MA+ patients presented less frequently hypertension (OR 0.349 95% CI 0.167–0.470; p=0.005) and dyslipidemia (OR 0.523 95% CI 0.280–0.974; p = 0.041). After adjusting also for risk factors, the MA+ group had less frequently symptomatic large vessel stenosis (OR 0.126 95% CI 0.017–0,924; p = 0.042) and clinical atherosclerosis (OR 0.103 95% CI 0.014–0.761; p = 0.026), while intima–media thickness did not differ (p = 0.395).DiscussionCryptogenic and cerebellar stroke and fewer vascular risk factors and clinical atherosclerosis seem to characterize stroke patients with MA.

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“…2,4,5 Only one study reported a greater volume of cerebral infarct in patients with migraine, but this study only included patients aged <45 years. 18 Other factors associated with a poor prognosis for stroke were older age and higher scores on the NIHSS scale. This has biological plausibility and agrees with the literature.…”

Section: Discussionmentioning

confidence: 99%

Assessing the influence of migraine on ischemic penumbra and on the prognosis of ischemic stroke: A prospective cohort study

2023

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Introduction There is controversy as to whether migraine affects the behavior of ischemic penumbra during the acute phase of an ischemic stroke, thereby accelerating the formation of cerebral infarction. Objectives To assess whether migraine modifies the existence and volume of the divergence between the areas of diffusion and perfusion in the stroke (the penumbra) and whether migraine implies a poorer prognosis after the stroke. Methods This was a prospective cohort study. We included hospitalized patients with ischemic stroke within 72 h of symptom onset (convenience sampling). A semi‐structured questionnaire, the National Institute of Health Stroke Scale, and the modified Rankin Scale (mRS) were used. Patients underwent magnetic resonance imaging (MRI) of the brain with diffusion and with perfusion. Patients were assessed by telephone 3 months after the stroke to determine the prognosis. Scores of > 2 on the mRS were considered to have a poor prognosis. Results A total of 221 patients were included, 131/221 (59%) of whom were male, and with a mean (SD) age of 68.2 (13.8) years. Ischemic penumbra analysis was performed in 118 patients. There was no association between migraine and the absence of ischemic penumbra (16/63 [25%] vs. 12/55 [22%]; odds ratio 1.22, 95% confidence interval 0.52–2.87; p = 0.64). There was no difference in stroke volume between those with and without migraine (median [interquartile range] 1.0 [0.4–7.9] vs. 1.8 [0.3–9.4] cm3; p = 0.99). Migraine was not associated with the stroke prognosis after multivariable analysis. Conclusion Migraine is not associated with the absence of ischemic penumbra, the volume of the ischemic penumbra, or the stroke prognosis.

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History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS)

Cited by 10 publications

References 31 publications

WITHDRAWN: Combination of Paeoniflorin and Calycosin-7-glucoside Promotes Ischemic Stroke Recovery via the PI3K/AKT Signaling Pathway

WITHDRAWN: Combination of Paeoniflorin and Calycosin-7-glucoside Promotes Ischemic Stroke Recovery via the PI3K/AKT Signaling Pathway

Stroke territory and atherosclerosis in ischemic stroke patients with a history of migraine with aura

Assessing the influence of migraine on ischemic penumbra and on the prognosis of ischemic stroke: A prospective cohort study

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