History of periodontal treatment and risk for intrauterine growth restriction (IUGR)

Ananth, Cande V.; Andrews, Howard; Papapanou, Panos N.; Ward, Angela; Bruzelius, Emilie; Conicella, Mary Lee; Albert, David A.

doi:10.1186/s12903-018-0623-2

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…On the contrary, there is strong evidence that periodontal diseases can lead to IUGR since transient bacteraemia may facilitate dissemination of oral bacteria and/or proinflammatory mediators to the uterus, with subsequent infiltration of the amniotic fluid and the umbilical cord and invasion of the placenta. Some authors suggest that advanced periodontal diseases may be related to more frequent adverse pregnancy outcome including preterm birth [67,68]. However, in our study group (where no signs of advanced periodontal disease were present), preterm delivery was not observed.…”

contrasting

confidence: 74%

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Zygula

Kosiński

Wroczyński

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aim. Pregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity. Material and Methods. A total of 104 pregnant women (n=104; 27 with PIH, 30 with IUGR, and 47 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), aldehyde dehydrogenase (ALDH), and activity of glutathione peroxidase (GPx) and glutathione transferase (GST) in plasma/whole blood and/or saliva were analysed. Dietary nutrient intake was calculated using a Semiquantitative Food Frequency Questionnaire (SFFQ). Oral health was assessed to eliminate patients with bleeding, severe periodontitis, and other dental pathologies. Results. In the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health. Conclusion. Oxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.

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contrasting

confidence: 74%

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Zygula

Kosiński

Wroczyński

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Our study is in agreement with previous studies of Ananth et al ., and Chanomethaporn et al . [ 1 3 ] Other comparative studies also showed a significant difference for the other clinical observations. Many authors have suggested a need for health professionals to advocate for oral health and its significance during pregnancy.…”

Section: Discussionmentioning

confidence: 89%

Impact of Chronic Periodontitis on Intrauterine Growth of the Fetus

Iqbal¹,

Lakkappa

Chhabra

et al. 2022

Journal of Pharmacy and Bioallied Sciences

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Introduction: The human body goes through a roller coaster of hormonal changes during pregnancy. The periodontal pathologies may alter and may bring about different/altered responses to normal stimuli. Hence, in our study, we assessed the relation between the chronic periodontitis and its impact on the intrauterine growth of the fetus. Material and Method: We conducted a retrospective observational study, where the data was collected from the institutional records. We included 200 pregnant subjects and grouped them equally as those with and without periodontal pathologies. We compared the groups for various parameters of the subject and the new born, and measured the significance deliberating P < 0.05 as significant. Results: We observed that among the various clinical parameters, the female subjects were exponentially prone to “vulvo-vaginitis, premature rupture of membranes” and the new born had restricted growth. Conclusion: Oral health affects the general health. The periodontal disease specifically has an adverse impact among pregnant women. Hence care should be given to oral hygiene maintenance.

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“…Moreover, inflammatory responses including the shifting of Th2 toward Th1, increasing oxidative stress, anti-angiogenic proteins, vascular endothelial growth factor receptor 1 and complement C5a could potentially enhance the development of preeclampsia (Nourollahpour Shiadeh et al, 2017 ). Ananth et al has reported the association between intrauterine growth restriction and maternal periodontitis (Ananth et al, 2018 ). Since severe and early onset preeclampsia were associated significantly with fetal growth restriction, this could contribute to the mechanism underlying the association between preeclampsia and periodontitis (Odegård et al, 2000 ).…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis

Akhter

Coulton

et al. 2022

Matern Child Health J

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Objectives A conflicting body of evidence suggests localized periodontal inflammation spreads systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aim to specifically evaluate the relationship between periodontitis and preeclampsia. Methods Electronic searches were carried out in Medline, Pubmed, Embase, Lilacs, Cochrane Controlled Clinical Trial Register, CINAHL, ClinicalTrials.gov, and Google Scholar with no restrictions on the year of publication. We identified and selected observational case–control and cohort studies that analyzed the association between periodontal disease and preeclampsia. This meta-analysis was conducted following the PRISMA checklist and MOOSE checklist. Pooled odds ratios, mean difference, and 95% confidence intervals were calculated using the random effect model. Heterogeneity was tested with Cochran’s Q statistic. Results Thirty studies including six cohort- and twenty-four case–control studies were selected. Periodontitis was significantly associated with increased risk for preeclampsia (OR 3.18, 95% CI 2.26 – 4.48, p < 0.00001), especially in a subgroup analysis including cohort studies (OR 4.19, 95% CI 2.23 – 7.87, p < 0.00001). The association was even stronger in a subgroup analysis with lower-middle-income countries (OR 6.70, 95% CI 2.61 – 17.19, p < 0.0001). Conclusions Periodontitis appears as a significant risk factor for preeclampsia, which might be even more pronounced in lower-middle-income countries. Future studies to investigate if maternal amelioration of periodontitis prevents preeclampsia might be warranted.

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History of periodontal treatment and risk for intrauterine growth restriction (IUGR)

Cited by 9 publications

References 25 publications

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

Impact of Chronic Periodontitis on Intrauterine Growth of the Fetus

Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis

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