History of Spinal Neurosurgery and Spine Societies

Zılelı, Mehmet; Sharif, Salman; Fornari, Maurizio; Ramani, Premenand; Jian, Fengzeng; Fessler, Richard G.; Kim, Se-Hoon; Takami, Toshihiro; Shimokawa, Nobuyuki; Dechambenoit, Gilbert; Qureshi, Mahmood; Konovalov, N A; Masini, Marcos; Osorio-Fonseca, Enrique; Bajamal, Abdul Hafid; Parthiban, J.K.B.C.; Sih, Ibet Marie; Alves, Óscar L.; Oertel, Joachim; Rasulić, Lukas; Costa, Francesco; Peul, Wilco C.; Sharma, Krishna Kant; Eldin, Mohamed Mohi; Ismail, Nasiru Jinjiri; Hossain, Mohammad Afzal; Kalevski, Svetoslav; Hausmann, Oliver; Yaman, Onur; Arif, Shahswar; Brady, Zarina

doi:10.14245/ns.2040622.311

Cited by 6 publications

(3 citation statements)

References 73 publications

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“…Assessment of MRI accuracy is an interesting discussion because until now MRI is the imaging of choice for the most reliable diagnosis (reference standard) to date, namely findings during surgery (Vali Y et al, 2021). This study helps clinicians in the decision making of the operative action plans apart from the clinical examination of the patient because preoperative preparation is very influential to the outcome (Zileli M et al, 2020). A false positive (FP) value represents the surgery that is actually not needed by the patient and conversely, a high false-negative (FN) value reflects the preoperative examination is at risk of misdiagnosis so that the patient does not get the best treatment.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of contrast and non-contrast 1.5 tesla magnetic resonance imaging for lumbar herniated nucleus pulposus based on surgical findings

Harmawan

Apriawan

Subagio

et al. 2022

ijhs

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This study aims to provide the latest information regarding the accuracy of contrast and non-contrast 1.5 Tesla MRI in the diagnosis of lumbar Herniated Nucleus Pulposus (HNP) compared with surgical findings. We included studies with subjects diagnosed with lumbar HNP due to degenerative processes, preoperative 1.5 Tesla contrast, and non-contrast MRI and described the number of findings of MRI diagnostic tests (index test) on the actual conditions found during surgery (reference standard). We searched literature from 5 databases: ProQuest, Pubmed, Cochrane Library, Biomed Central, and ScienceDirect. The sensitivity and specificity of contrast and non-contrast 1.5 Tesla MRI ranged between 64-95% and 55-100% (95% CI) with the area under the curve above the threshold on the ROC curve. Two studies compared the accuracy of MRI and Computed Tomography (CT) myelography with a wider ROC curve on CT myelography than on MRI. The ROC curve which has a wide area under the curve above the threshold depicts the relationship between sensitivity and specificity, shows that contrast non-contrast 1.5 Tesla MRI has a good accuracy in HNP diagnostic.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of contrast and non-contrast 1.5 tesla magnetic resonance imaging for lumbar herniated nucleus pulposus based on surgical findings

Harmawan

Apriawan

Subagio

et al. 2022

ijhs

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“…Він першим описав лопатково-перонеальну аміотрофію і спадкову міоклонічну дистонію [7]. Коновалов М. в 40-х роках при досліджені прогресуючих дегенеративних захворювань відкрив взаємозв'язок між дисфункцією печінки та патологією нервової системи, він вперше описав гепатоцеребральну дистрофію, відому як Хвороба Вільсона-Коновалова [8].…”

Section: токсичні моделі паркінсонізмуunclassified

Toxic Models of Parkinson's Disease: History and Prospects

Yaroshenko¹

2021

Ukr. ž. med. bìol. sportu

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The review article presents data on the history of research of extrapyramidal system dysfunctions, modern ideas about the etiology and diagnosis of Parkinson's disease, as the most common disease of the group of extrapyramidal disorders. Currently, no concept of effective therapy for patients with extrapyramidal system dysfunction has been developed, but it has been proven that the probability of developing the disease largely depends on the genetic predisposition and the level of environmental pollution. In the early stages, the disease is slow and asymptomatic, but gradually more than half of patients with Parkinson's disease die, and others need outside care. According to experts, in the near future, Parkinson's disease will become a problem for a significant part of people, because today it affects more and more people of working age. Under such conditions, reliable and early diagnosis of the disease is of great importance, which guarantees timely and most effective treatment. Modern therapies fail to stop the progressive death of the dopaminergic neurons of the substantia nigra, but traditional treatment can achieve symptomatic relief. Currently, it is known that the probability of developing Parkinson's disease depends on the genetic predisposition and the level of man-made environmental stress. The researchers consider that the pathological development of Parkinson's disease in the brain begins in the lower structures of the brain stem with the involvement of the caudal-Rostral nuclei, as well as the involvement of the cortico-basal ganglia-cerebellar pathways. The pathological process affects the ascending pathways and gradually passes to the midbrain, directly to the black substance, spreads from there and weakens the mesocortex and neocortex. Injuries in the brain stem lead to disorganization of the cortico-basal ganglia and cerebellar pathways, followed by the formation of alternative pathways to compensate for the initial disorders in the early stages of the disease. In addition, in Parkinson's disease, intracellular Lewy bodies and neurites formed by the protein alpha-synuclein are created, which are found in the autopsy material of most patients. Poor results of diagnostic evaluation and treatment of Parkinson's disease are usually associated with a lack of understanding of the pathogenesis of Parkinson's disease. The study of the biological basis and pathogenesis of Parkinson's disease is an important task of a whole complex of scientific studies of extrapyramidal system dysfunction. Conclusion. The article discusses the creation of toxic models of Parkinson's disease in vivo and in vitro, which help to recreate the pathogenesis of the disease for early diagnosis and the development of new ways to treat neurodegenerative diseases. In toxic models of Parkinsonism, not only deficits of motor functions such as bradykinesia, tremor, and posture disorders are actively studied, but also non-motor symptoms such as sleep disorders, neuropsychiatric and cognitive abnormalities

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“…Conditions in the United States, the economic burden due to LBP causes losses of 84.1 to 624.8 million US dollars annually, which is used, among others, for medical purposes, insurance, decreased production capacity and benefits provided to patients with disabilities. (Jiang and Chen, 2018;Che et al, 2019;Collaborators, 2020;Zileli et al, 2020;Williamson and Smith, 2021).…”

Section: Introductionmentioning

confidence: 99%

relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

Harmawan

Parenrengi

Bajamal

et al. 2022

ijhs

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This study aims to determine the relationship between disc height as objective data and the degree of disc degenerative Pfirrmann score assessed on MRI imaging, the imaging modality with the best current degenerative lumbal disease’s diagnosis. The measurements of disc height and Pfirrmann degenerative degree of the intervertebral disc were performed on a T2WI MRI sequence, sagittal sections of the 1-2 lumbar intervertebral discs to 5-sacral 1 (5 disc levels) using dicom MRI data using the Horos dicom viewer software. Analysis of the correlation between disc height and the degree of degeneration on MRI was performed using the Pearson correlation test. Statistical tests were performed using SPSS software (SPSS Inc., Chicago, IL, USA). The results were evaluated with a significance value of p<0.005. The results of the Pearson test in the three groups of patients, namely in the HNP L4-L5, HNP L5-S1 and HNP patient groups at both disc levels showed an inverse relationship between disc height and Pfirrmann's degenerative degree which was statistically significant, with values in the L4 HNP group.

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History of Spinal Neurosurgery and Spine Societies

Cited by 6 publications

References 73 publications

Diagnostic accuracy of contrast and non-contrast 1.5 tesla magnetic resonance imaging for lumbar herniated nucleus pulposus based on surgical findings

Diagnostic accuracy of contrast and non-contrast 1.5 tesla magnetic resonance imaging for lumbar herniated nucleus pulposus based on surgical findings

Toxic Models of Parkinson's Disease: History and Prospects

relationship between intervertebralis disc height and pfirrmann’s degenerative degree:

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