History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications

Martin, Roman R Rodriguez; Gonzalez, Olivia Gonzalez; Gonzalez, Carolina Rodriguez; Gonzalez, Rene R. Rodriguez

doi:10.1016/j.intimp.2023.110167

Cited by 1 publication

(1 citation statement)

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“…An extensive series of toxicological studies were also performed, confirming that it is a safe thymic factor. Several clinical trials have been conducted in patients with immunodeficiency disorders, recurrent infections, autoimmune diseases, cancer and other diseases [26] . In 1994, the Cuban Regulatory Agency (CECMED) granted a license for the treatment of recurrent infections in elderly patients [27] .…”

Section: Biomodulina Tmentioning

confidence: 99%

Treatment with the thymic polypeptide fraction Biomodulina T potentiates immune responses in older adults and cancer patients: an overview of the most recent studies

Saavedra,

Laura A耖-Kour�Nuris Led髇,

Crombet

et al. 2024

Ageing and Cancer Research &Amp; Treatment

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Over the past 50 years, the world has experienced a progressive demographic shift resulting in a higher proportion of older adults in the general population. Aging itself is a complex biological phenomenon, characterized in part by changes in the immune system, known as "immunosenescence," that make older adults more susceptible to infections, cardiovascular and autoimmune diseases, and cancer. Several strategies have been proposed to reverse immunosenescence. These include the use of hormones, cytokines, and thymic factors. Biomodulina T (BT) is a polypeptide fraction derived from bovine thymus. Intervention with BT expands naïve CD4+ T cells while decreasing the frequency of CD4+ and CD8+ T cells expressing PD1 in older adults and patients diagnosed with advanced lung cancer. This brief review aims to present the most recent evidence on the effect of BT on the immune system in older adults and patients diagnosed with advanced lung cancer.

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Section: Biomodulina Tmentioning

confidence: 99%