History of Vaccine Development

Plotkin, Stanley А.

doi:10.1007/978-1-4419-1339-5

Cited by 38 publications

(4 citation statements)

References 443 publications

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“…"Modern Vaccines-an Overview". Acta Scientific Veterinary Sciences 4.3 (2022): 72-76. bacteria in a laboratory The earliest of vaccines were developed on the idea of attenuation [2,4].…”

Section: Live Attenuated Vaccines Are Derived From Disease Causing Vi...mentioning

confidence: 99%

“…The pathogen particles are destroyed and cannot replicate, but the antigens elicit an immune response [1]. Louis Pastuer discovered in 1881 that chickens injected with dead cultures of Pasteurella multocida did not contract disease when injected with live culture of Pasteurella multocida [1,2] Using similar principles he invented vaccines for rabies and anthrax. Inactivated Vaccines elicit a feebler immune response when compared to live attenuated vaccines but are safe for use in immuno-compromised individuals unlike live attenuated vaccines.…”

Section: Inactivated Vaccinementioning

confidence: 99%

“…Mankind has greatly benefited from vaccines for more than two centuries, yet the search for efficient vaccines is still a never-ending pursuit, The history of vaccines and vaccination starts with the first effort to prevent disease in the society. Smallpox was prevalent and is believed to have infested india and egypt over 3,000 years ago [1,2]. Observations about smallpox were made by physicians and scholars like Thucydides who reported that people affected by smallpox were immune from the future infections in 430 BC [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Smallpox was prevalent and is believed to have infested india and egypt over 3,000 years ago [1,2]. Observations about smallpox were made by physicians and scholars like Thucydides who reported that people affected by smallpox were immune from the future infections in 430 BC [2,3]. The evidence indicates that inoculation of smallpox material into sub-cutis was practiced in Indian subcontinent, ottoman empire and china by 1000 AD [1,4,14].…”

Section: Introductionmentioning

confidence: 99%

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Modern Vaccines- an Overview

Bharat¹

2022

Act Sci VetSci

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Vaccines are one of the greatest inventions in modern medicine, vaccines have played a significant role in control, eradication of lethal diseases like smallpox and are responsible for the robust improvement in life expectancy over the past 2 centuries. Edward jenner pioneered the development of vaccinology by demonstrating immunity to smallpox when inouculated with cow pox scabs. The development of live attenuated vaccines and inactivated vaccines in 19 th played a major role in prevention of diseases like cholera, rabies, anthrax. Early 20 th century saw development of sub-unit vaccines which possessed only the antigenic part of microbe making it safer than live attenuated vaccines, with the advent of recombinant DNA technology and proteomics in the later decades of 20 th century modern vaccine delivery platforms like recombinant viral vector vaccines, bacterial vector vaccines, DNA vaccines, Mrna vaccines, DNA vaccines, Outer membrane vesicles, virus like particles had a rapid growth, with many viral, bacterial vaccines being currently used and relatively newer vaccine technologies like Mrna vaccines, DNA vaccines, Virus like particles show a promising future with several vaccine candidates in development pipeline.

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“…"Modern Vaccines-an Overview". Acta Scientific Veterinary Sciences 4.3 (2022): 72-76. bacteria in a laboratory The earliest of vaccines were developed on the idea of attenuation [2,4].…”

Section: Live Attenuated Vaccines Are Derived From Disease Causing Vi...mentioning

confidence: 99%