History of Vaccine Process Development

Pujar, Narahari S.; Sagar, Sangeetha L.; Lee, Ann L.

doi:10.1002/9781118870914.ch1

Cited by 2 publications

(2 citation statements)

References 127 publications

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“…Three effective rotavirus vaccines have now been licensed and are recommended for use in all countries by the WHO, particularly in those countries with a high diarrhoea mortality rate for children younger than 5 years. Pujar et al (2014) explain that the vaccine antigen is generated via a cultivation process (we refer to it as the primary process) and is characterized by an appropriate choice of cell substrate, growth media and fermentation or cell culture conditions that reproducibly produce the antigen in large quantities. Subsequently, the vaccine purification process may remove host cell impurities, process additives and yields a bulk vaccine.…”

Section: Application To the Design Of A Rotavirus Vaccine Supply Chainmentioning

confidence: 99%

The trade-off between inventories, lead time and capacity: application to vaccine supply chain design

Lemmens¹

2018

4OR-Q J Oper Res

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and Sha Zhu. Furthermore, I also want to thank Inês Marques from the University of Lisbon for her collaboration on the university course timetabling problem and for the pleasant meetings we had in Leuven, Brussels and Lisbon.My dearest friends from my five-year stay at the student residence English summary vii Nederlandse samenvatting ix Table of contents xi List of Figures xv List of Tables xvii1 Introduction 1 2 A stakeholder-based framework for vaccine supply chain design 5 2.1 Introduction .

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Section: Application To the Design Of A Rotavirus Vaccine Supply Chainmentioning

confidence: 99%

The trade-off between inventories, lead time and capacity: application to vaccine supply chain design

Lemmens¹

2018

4OR-Q J Oper Res

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“…Since 2006, two effective rotavirus vaccines have been licensed and are recommended for use in all countries by the WHO, particularly in those countries with a high diarrhoea mortality rate for children younger than 5 years. [Pujar et al, 2014] explain that the vaccine antigen is generated via a cultivation process (we refer to it as the primary process) and is characterized by an appropriate choice of cell substrate, growth media and fermentation or cell culture conditions that reproducibly produce the antigen in large quantities. Subsequently, the vaccine purification process may remove host cell impurities, process additives and yields a bulk vaccine.…”

Section: Impact Of Capacity Issuesmentioning

confidence: 99%

Performance Measurement of a Rotavirus Vaccine Supply Chain Design by the Integration of Production Capacity into the Guaranteed Service Approach

et al. 2016

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Previous research has integrated multi-echelon inventory management into the design of a responsive supply chain by the use of the guaranteed service approach. We build further upon this work by integrating the production capacity and product flow to minimize the supply chain's inventories. The production capacity is modeled with a queuing network to handle the variability of the batch production processes as well as the demand variability. We test and validate our model with adapted instances from literature and apply it to the rotavirus vaccine supply chain. This vaccine supply chain is seen as complex on the manufacturing side as well as on the distribution side. For our industrial application we show how this work is embedded in a scenario approach and the contribution of our model to evaluate a single scenario according to multiple performance indicators. For this paper, our scenarios consist of different lead time reduction programmes and varying demand levels. We demonstrate how to extract the best performing scenario.

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History of Vaccine Process Development

Cited by 2 publications

References 127 publications

The trade-off between inventories, lead time and capacity: application to vaccine supply chain design

The trade-off between inventories, lead time and capacity: application to vaccine supply chain design

Performance Measurement of a Rotavirus Vaccine Supply Chain Design by the Integration of Production Capacity into the Guaranteed Service Approach

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