History of Vitamin E Research

Birringer, Marc; Blumberg, Jeffrey B.; Eggersdorfer, Manfred; Frank, Jan; Weber, Peter

doi:10.1007/978-3-030-05315-4_2

Cited by 5 publications

(2 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, VitE deficiency in preterm newborns may cause macrocytic anemia and increased hemolysis of RBCs. On the other hand, excessive VitE toxicity has been linked to headaches, weariness, dizziness, intestinal irritation, prolonged prothrombin time, and difficulty with the absorption of vitamins A and K. [15][16][17][18][19][20][21] Due to the assumption that VitE, as an antioxidant, may reduce morbidity and mortality, VitE is currently one of the most regularly used dietary supplements. [22] Based on this, it is thought that VitE may play a role in reducing hemolysis in patients with G6PD deficiency.…”

Section: Introductionmentioning

confidence: 99%

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

Background: As an antioxidant, vitamin E (VitE) may benefit the erythrocytes by protecting glutathione from oxidation by free radicals and peroxide-generating processes. Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines when reporting this systematic review. We searched 6 electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) until May 8, 2022. We included all relevant studies. According to the study design, the Cochrane assessment tool (Risk of Bias 2), Risk Of Bias In Non-randomized Studies - of Interventions checklists, and National Institutes of Health tools were used to assess the risk of bias. Continuous data were pooled as a mean difference (MD) with a relative 95% confidence interval. The protocol was registered on PROSPERO (CRD42022333848). Results: Six studies were included in the meta-analysis with a total of 181 patients. Compared with the control group, VitE significantly improved the hemoglobin level for chronic hemolysis (MD = 2.72 g/dL, P < .0001) and for acute hemolysis (MD = 1.18 g/dL, P < .0001). It also decreased the reticulocyte level for chronic hemolysis (MD = −1.39 P < .0001) and for acute hemolysis (MD = −1.42%, P < .0001). For before and after studies, the use of VitE significantly improved the level of packed cell volume (MD = 0.56%, P < .00001), red blood cell half-life (MD = 2.19 days, P < .0001), and decreased the reticulocytes level (MD = −1.41%, P < .00001). Conclusion: Among patients with glucose-6-phosphate dehydrogenase deficiency, VitE might provide benefits such as increasing the hemoglobin, packed cell volume levels, red blood cell half-life, and decreasing the reticulocyte level, so reducing hemolysis. Further high-quality, well-designed randomized controlled trials are recommended.

show abstract

Section: Introductionmentioning

confidence: 99%

The potential role of vitamin E in patients with glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Die Entdeckung von Vitamin E jährt sich dieses Jahr zum hundertsten Mal und wir stellen fest, dass eine enorme Menge an wissenschaftlichen Daten zu diesem Mikronährstoff publiziert wurde [1]. Wir haben Kenntnis von den antioxidativen Eigenschaften des Vitamins, und die Ergebnisse von Tier-und Humanstudien sind als Referenzwerte in die Zufuhrempfehlungen der nationalen und interna tionalen Fachgesellschaften eingegangen.…”

Section: Introductionunclassified

Vitamin E – von der Entdeckung zu biologischen Funktionen

Birringer¹

2022

Ernährung & Medizin

View full text Add to dashboard Cite

Seit der Entdeckung von Vitamin E und seiner antioxidativen Wirkung in Tieren und im Menschen hat es sehr viele Studien darüber gegeben. Dennoch sind trotz der Fülle an Daten noch einige Zusammenhänge ungeklärt. Dieser Artikel soll ein geschichtlicher Abriss zu der Entdeckung des Vitamins und den Meilensteinen zur Vitamin-E-Forschung sein. Darüber hinaus werden Forschungslücken aufgedeckt und ein Blick in die Zukunft der Vitamin-E-Forschung gewagt.

show abstract