History, phytochemistry, experimental pharmacology and clinical uses of honey: A comprehensive review with special reference to Unani medicine

Nikhat, Sadia; Fazil, Mohammad

doi:10.1016/j.jep.2021.114614

Cited by 45 publications

(30 citation statements)

References 157 publications

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“…Honey is called ‘medical-grade honey’ because of its antibacterial activity, use in several medical treatments, such as diabetes, and promotion of human health as a functional food [ 10 ]. The use of honey in the treatment of diabetes mellitus was confirmed by several studies (e.g., [ 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 ]). For the potential role of honey in managing glycemia (human blood sugar), honey as a sweetener could be added to food, such as yogurt, which could be consumed daily for chronic diseases [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 78%

“…About 300 different types of honey are well known (e.g., acacia, citrus, clover, honeydew, Majra, Manuka, mountain, Sidr, and Tualang honey) which are differentiated by their sources and their seasonal and geographical origin as well as their processing, harvesting, and storage conditions [ 8 , 9 ]. Honey is called ‘medical-grade honey’ because of its antibacterial activity, use in several medical treatments, such as diabetes, and promotion of human health as a functional food [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Prokisch

El-Ramady

Daróczi³

et al. 2022

Plants

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The human blood sugar level is important and should be controlled to avoid any damage to nerves and blood vessels which could lead to heart disease and many other problems. Several market-available treatments for diabetes could be used, such as insulin therapy, synthetic drugs, herbal drugs, and transdermal patches, to help control blood sugar. In a double-blind human study, four kinds of honey from bees fed on acacia, sea buckthorn, chlorella alga, and green walnut extracts were used in fortifying yogurt for controlling human blood sugar. The impact of a previously fortified honey was investigated on blood levels and other parameters of healthy individuals in a human study with 60 participants. The participants received 150 mL of yogurt mixed with 30 g of honey every morning for 21 days. Before and after the study period, the basic blood parameters were tested, and the participants filled out standardized self-report questionnaires. Acacia honey was the traditional honey used as a control; the special honey products were produced by the patented technology. The consumption of green walnut honey had a significant effect on the morning blood sugar level, which decreased for every participant in the group (15 people). The average blood sugar level at the beginning in the walnut group was 4.81 mmol L−1, whereas the value after 21 days was 3.73 mmol L−1. The total decrease level of the individuals was about 22.45% (1.08 mmol L−1). Concerning the sea buckthorn and chlorella alga-based honey product groups, there was no significant change in the blood sugar level, which were recorded at 4.91 and 5.28 mmol L−1 before treatment and 5.28 and 5.07 mmol L−1 after, respectively. In the case of the acacia honey group, there was a slight significant decrease as well, it was 4.77 mmol L−1 at the beginning and 4.27 mmol L−1 at the end with a total decrease rate of 10.48%. It could thus be concluded that the active ingredients of green walnut can significantly decrease the blood sugar level in humans. This study, as a first report, is not only a new innovative process to add herbs or healthy active ingredients to honey but also shows how these beneficial ingredients aid the honey in controlling the human blood sugar level.

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Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Prokisch

El-Ramady

Daróczi³

et al. 2022

Plants

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“…Among functional properties of honey are antibacterial (Mohan et al, 2017), antioxidant (Israili, 2014), antitumour (Nikhat and Fazil, 2022), anticancer (Mutlu et al, 2015;Cianciosi et al, 2018), anti-inflammatory, antibrowning and antiviral (Martos et al, 2008) effects. Phenolic components are responsible for functional properties of a lot of foods such as antioxidant capacity (Almaraz et al, 2007), antibacterial capacity, antiviral capacity and anti-inflammatory capacity (Fiorani et al, 2006).…”

Section: Effects Of Honey On Healthmentioning

confidence: 99%

“…It is indicated that methyl glyoxal content of the honey from manuka tree in New Zealand is good for gastroenterological system disorders (Yeşilada, 2019). Manuka, honeydew, and thyme honey are effective against prostate cancer cell lines in terms of anticancer activity (Nikhat and Fazil, 2022). As a new potential functional food, strawberry tree honey decreases the cellular proliferation colon cancer and the ability of forming colonies (Afrin et al, 2019).…”

Section: Studies On Honey As a Functional Foodmentioning

confidence: 99%

Honey as a Functional Food; Its Culinary Status

Güleç

Sarper

2022

Turkish JAF Sci.Tech.

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Using functional foods which are recently a rising value in the food science arouses curiosity in terms of health among people. Honey, as a natural functional food, might play an important role in the increase of this value with a large but conscious use of it in kitchens. Having a prebiotic property with its oligosaccharide components, honey has a characteristic of supporting the increase of probiotic Bifidobacterium and lactobacilli bacteria. In the current study, the culinary status of honey was investigated depending on the views of professional chef trainers. For honey that shows different compositions, chefs point out that, because of the changes of nectars in the flora collected by bees, the qualitative honey bought from local producers could be a more functional food by using it with sauces, milk products like yoghurt and cheese, with such spices as ginger, turmeric, black pepper, and cinnamon at room temperature without an application of heat treatment.

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“…Thirdly, referring to the potential wound-healing claim, the balms/resins were tested in an HaCaT keratinocyte based in vitro assay for enhanced re-epithelization. Lysophosphatidic acid (LPA, 10 µM) and extracts of several medicinal plants well known for their wound-healing properties (birch [ 16 , 17 ], marigold [ 18 , 19 , 20 ], St. John´s wort [ 21 , 22 ], manuka honey [ 23 , 24 ]) served as references in these experiments.…”

Section: Introductionmentioning

confidence: 99%

Exudates of Picea abies, Pinus nigra, and Larix decidua: Chromatographic Comparison and Pro-Migratory Effects on Keratinocytes In Vitro

Goels

Eichenauer

Tahir

et al. 2022

Plants

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Balms and resins of Picea abies, Larix decidua, and Pinus nigra are traditionally used to treat wounds. Three chromatographic techniques differing in separation capacity and technical demands were employed to distinguish among these plant exudates. A TLC method was established for fingerprint comparison, providing a quick overview of a large number of samples at low cost. HPLC-DAD (RP18) and UHPSFC-DAD (Torus 2-Picolylamin), hyphenated to ESI-MS, represented orthogonal chromatographic systems with high separation performance. The developed methods allow for the separation and detection of major and minor constituents belonging to different compound classes (phenyl carboxylic acids, lignans, diterpene resin acids). The qualitative compositions of the diterpene resin acids, the main compounds in the exudates, were comparable in all three genera. Differences were detected in the distribution of hydroxylated diterpene resin acids, pinoresinol, and hydroxycinnamic acids. The three tested chromatographic systems with varying demands on lab equipment offer appropriate tools for the quality assessment of Picea abies, Larix decidua, and Pinus nigra. The extracts were furthermore tested at three different concentrations (10 µg/mL, 3 µg/mL, and 1 µg/mL) for boosted re-epithelialization, a crucial step in the wound-healing process, in an in vitro HaCaT keratinocyte-based scratch assay. Lysophosphatidic acid (LPA, 10 µM) and extracts of several medicinal plants well known for their wound-healing properties (birch, marigold, St. John’s wort, manuka honey) were used as positive controls. Picea abies and Pinus nigra showed concentration dependency; significant activity was measured for Larix decidua at 3 µg/mL.

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History, phytochemistry, experimental pharmacology and clinical uses of honey: A comprehensive review with special reference to Unani medicine

Cited by 45 publications

References 157 publications

Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Honey as a Functional Food; Its Culinary Status

Exudates of Picea abies, Pinus nigra, and Larix decidua: Chromatographic Comparison and Pro-Migratory Effects on Keratinocytes In Vitro

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