Blackleg is an endogenous acute infection that principally affects cattle. Blackleg is generally fatal bacterial diseases of young cattle or sheep of any age. The disease is caused by Clostridium chauvoei, an anaerobic spore forming bacterium seen as an acute, localized inflammation of muscle tissue due to growth of the blackleg organisms. This followed by generalized toxemia or poisoning of the animal causing rapid death. The disease is widely distributed in the world. Blackleg can occur at any time of the year; more loss of cattle is seen during warm months of the year. Blackleg has been found in cattle as young as two-month-old, most loss occur in cattle, the best conditioned animals, where there is an abundance of feed. It is prevented by vaccination when out breaks occur; in early stage of the disease it is treated by antibiotic mostly penicillin is effective treatment to the disease. Control of this disease is based on stringent husbandry measures and scheduled vaccination plan. In recent years, the major virulence factors of C. chauvoei have been discovered and described. However, the pathogenesis of blackleg in cattle and, circulation of the pathogen from point of entry to target tissues is yet not fully elucidated. Therefore, the objectives of this paper are to summarizes the latest review of literature that significantly contributed for understanding the disease in cattle and provides a foundation to preventive strategies.