Histotripsy of the Prostate Using a Commercial System in a Canine Model

Roberts, William W.; Teofilovic, Dejan; Jahnke, Russell C.; Patri, Justin; Risdahl, Jack M.; Bertolina, James A.

doi:10.1016/j.juro.2013.08.077

Cited by 35 publications

(28 citation statements)

References 21 publications

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“…While the canine prostate is the best and most readily available model of the human prostate, 25 2 important limitations impacted this study. The first limitation is that perineal urethrostomy created a large urethral opening just below the anus, which exposed the urethra to fecal contamination.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Image Guided Transurethral Ultrasound Prostate Ablation: A Preclinical Safety and Feasibility Study with 28-Day Followup

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Image Guided Transurethral Ultrasound Prostate Ablation: A Preclinical Safety and Feasibility Study with 28-Day Followup

et al. 2015

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“…A 700‐kHz, shock‐scattering histotripsy transducer(Histosonics, Ann Arbor, Michigan) was used to examine the propensity of the particles to seed cavitation under a low duty cycle insonation regime. The transducer consisted of 36 elements arranged in a 13‐cm aperture and an 11‐cm focal distance.…”

Section: Methodsmentioning

confidence: 99%

Novel acoustic coupling bath using magnetite nanoparticles for MR‐guided transcranial focused ultrasound surgery

et al. 2019

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Purpose Acoustic coupling baths, nominally composed of degassed water, play important roles during transcranial focused ultrasound surgery. However, this large water bolus also degrades the quality of intraoperative magnetic resonance (MR) guidance imaging. In this study, we test the feasibility of using dilute, aqueous magnetite nanoparticle suspensions to suppress these image degradations while preserving acoustic compatibility. We examine the effects of these suspensions on metrics of image quality and acoustic compatibility for two types of transcranial focused ultrasound insonation regimes: low‐duty cycle histotripsy procedures and high‐duty cycle thermal ablation procedures. Methods Magnetic resonance guidance imaging was used to monitor thermal ablations of in vitro gel targets using a coupling bath composed of various concentrations of aqueous, suspended, magnetite nanoparticles in a clinical transcranial transducer under stationary and flowing conditions. Thermal deposition was monitored using MR thermometry simultaneous to insonation. Then, using normal degassed water as a coupling bath, various concentrations of aqueous, suspended, magnetite nanoparticles were placed at the center of this same transducer and insonated using high‐duty cycle pulsing parameters. Passive cavitation detectors recorded cavitation emissions, which were then used to estimate the relative number of cavitation events per insonation (cavitation duty cycle) and the cavitation dose estimates of each nanoparticle concentration. Finally, the nanoparticle mixtures were exposed to low‐duty cycle, histotripsy pulses. Passive cavitation detectors monitored cavitation emissions, which were used to estimate cavitation threshold pressures. Results The nanoparticles reduced the MR signal of the coupling bath by 90% in T2‐ and T2*‐weighted images and also removed almost all imaging artifacts caused by coupling bath motion. The coupling baths caused <5% changes in peak temperature change achieved during sonication, as observed via MR thermometry. At low duty cycle insonations, the nanoparticles decreased the cavitation threshold pressure by about 15 ± 7% in a manner uncorrelated with nanoparticle concentration. At high duty cycle insonations, the 0.5 cavitation duty cycle acoustic power threshold varied linearly with nanoparticle concentration. Conclusions Dilute aqueous magnetite nanoparticle suspensions effectively reduced MR imaging artifacts caused by the acoustic coupling bath. They also attenuated acoustic power deposition by <5%. For low duty cycle insonation regimes, the nanoparticles decreased the cavitation threshold by 15 ± 7%. However, for high‐duty cycle regimes, the nanoparticles decreased the threshold for cavitation in proportion to nanoparticle concentration.

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“…With sufficiently high pressure and dose, histotripsy can completely fractionate soft tissues into an acellular liquid homogenate by inducing very large strains to the adjacent tissue structures (Parsons et al , 2006a; Vlaisavljevich et al , 2014a; Xu et al , 2005; Vlaisavljevich et al , 2016d). Histotripsy is currently being studied for many clinical applications where noninvasive tissue removal is desired including benign prostatic hyperplasia (Hempel et al , 2011; Roberts et al , 2014), kidney stones (Duryea et al , 2011), deep vein thrombosis (Maxwell et al , 2011a; Zhang et al , 2015), congenital heart disease(Owens et al , 2011; Xu et al , 2010), and cancer (Styn et al , 2010; Vlaisavljevich et al , 2016c; Vlaisavljevich et al , 2013b). …”

Section: Introductionmentioning

confidence: 99%

Effects off-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior

et al. 2017

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Histotripsy is an ultrasound ablation method that depends on the initiation of a cavitation bubble cloud to fractionate soft tissue. Although previous work has provided significant insight into the process of intrinsic threshold histotripsy, the majority of these studies have used highly focused (i.e. f-number<0.6) transducers. In this study, we investigate the effects of f-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior using a 500 kHz array transducer, with the effective f-number of the transducer varied from 0.51 to 0.89. The intrinsic threshold did not significantly change with f-number, with the threshold remaining ~27–30 MPa for all conditions. The predictability of intrinsic threshold histotripsy was further demonstrated by experiments comparing the predicted and experimentally measured bubble cloud dimensions, with results showing close agreement for all f-numbers. Finally, the effects of f-number on “bubble density” and tissue fractionation efficiency were investigated, with results supporting the hypothesis that the density of the bubbles within the bubble cloud significantly decreases at higher f-numbers, resulting in decreased fractionation efficiency. Overall, this study provides significant insight into the effects of f-number on intrinsic threshold histotripsy that will help to guide the development of intrinsic threshold histotripsy for specific clinical applications.

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Histotripsy of the Prostate Using a Commercial System in a Canine Model

Cited by 35 publications

References 21 publications

Magnetic Resonance Image Guided Transurethral Ultrasound Prostate Ablation: A Preclinical Safety and Feasibility Study with 28-Day Followup

Magnetic Resonance Image Guided Transurethral Ultrasound Prostate Ablation: A Preclinical Safety and Feasibility Study with 28-Day Followup

Novel acoustic coupling bath using magnetite nanoparticles for MR‐guided transcranial focused ultrasound surgery

Effects off-number on the histotripsy intrinsic threshold and cavitation bubble cloud behavior

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