2009
DOI: 10.1007/7355_2009_1
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Hit Triage: Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery

Abstract: This chapter describes the process of collecting and analyzing information in order to make decisions which help a project move through a key early stage in drug discovery. It explains, in general, the sources of hits for a drug discovery program and explores the link between potency and efficiency in evaluating lead matter. The chapter then illustrates the collection of both pharmacokinetic data as well as safety data, and describes the relevance of that data and the process of using it to make decisions. Of … Show more

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“…Moreover, they lack realism. Actual programs are stymied by optimization plateaus [43, 44], activity cliffs [45], and multiple simultaneous objectives that may be anti-correlated [46, 47].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, they lack realism. Actual programs are stymied by optimization plateaus [43, 44], activity cliffs [45], and multiple simultaneous objectives that may be anti-correlated [46, 47].…”
Section: Introductionmentioning
confidence: 99%