2020
DOI: 10.20944/preprints202010.0084.v1
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Hitting the Target but Missing the Point: Recent Progress Towards Adenovirus-Based Precision Virotherapies

Abstract: More people are surviving longer with cancer. Whilst this can be partially attributed to advances in early detection of cancers, there is little doubt that the improvement in survival statistics is also due to the expansion in the spectrum of treatments available for efficacious treatment. Transformative amongst those are immunotherapies, which have proven effective agents for treating immunogenic forms of cancer, though immunologically “cold” tumour types remain refractive. Oncolytic virus… Show more

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Cited by 5 publications
(3 citation statements)
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References 130 publications
(151 reference statements)
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“…It was shown that virus induced oncolysis results in apoptosis, necrosis, necroptosis, pyroptosis, or autophagy that releases signal molecules with a pathogen-associated molecular pattern (PAMP). Infected cells also release damage-associated molecules (DAMP), including HMGB1, heat shock proteins (HSP), intracellular matrix proteins, DNA, ATP, uric acid, or heparin sulphate [ 51 , 52 ]. These molecules stimulate the innate immune response and attract antigen-presenting cells (APCs).…”
Section: Oncolytic Adenoviruses and The Immune Systemmentioning
confidence: 99%
See 1 more Smart Citation
“…It was shown that virus induced oncolysis results in apoptosis, necrosis, necroptosis, pyroptosis, or autophagy that releases signal molecules with a pathogen-associated molecular pattern (PAMP). Infected cells also release damage-associated molecules (DAMP), including HMGB1, heat shock proteins (HSP), intracellular matrix proteins, DNA, ATP, uric acid, or heparin sulphate [ 51 , 52 ]. These molecules stimulate the innate immune response and attract antigen-presenting cells (APCs).…”
Section: Oncolytic Adenoviruses and The Immune Systemmentioning
confidence: 99%
“…The released virus progeny further infects the uninfected tumour cells and continues the viral spread. The immunostimulatory molecules released into the TME attract immune cells to the tumour and lead to the activation of both innate and adaptive immunity against the tumour (modified with permission from [ 52 , 54 ]).…”
Section: Figurementioning
confidence: 99%
“…These major challenges in the OV field in achieving tumour‐selective systemic delivery of OVs have seen significant progress in recent years with the development of ‘ precision virotherapies’, although significant challenges remain [ 5 , 6 ]. These advances and current challenges have been recently and extensively reviewed elsewhere [ 7 , 8 , 9 ].…”
Section: Oncolytic Virusesmentioning
confidence: 99%