HIV-1 associated cognitive/motor complex in an injecting drug user

Maxwell, Jonathan P.; Egan, Vincent; Chiswick, Ann; Burns, S; Gordon, Alison; Kean, D. M.; Brettle, R P; Pullen, Ian

doi:10.1080/09540129108251593

Cited by 10 publications

(1 citation statement)

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“…However, like homosexual cohorts (Messenheimer et al 1992), HIV seropositive drug users show significant, and progressive slowing of P3 latency with disease progression (Goodwin et al 1990) and measures of memory and attention in symptomatic HIV-positive drug users are significantly worse than either asymptomatic HIVpositive individuals, or control subjects (Egan et al 1992). Finally, HIV dementia in drug users is clinically the same as in other HIV risk categories (Maxwell et al 1991).…”

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confidence: 99%

The Edinburgh cohort of HIV-positive drug users: the relationship between auditory P3 latency, cognitive function and self-rated mood

Egan

Chiswick²,

Brettle³

et al. 1993

Psychol. Med.

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SynopsisOne hundred and six HIV-positive drug users were tested with a two-tone auditory evoked potential (AEP) task and a small battery of neuropsychological tests, to examine the relationship between the latency of the P300 component (P3) of the AEP, intellectual function, mood and drug use. Principal components analysis revealed a significant correlation between P3 latency and the first principal component (r = −0·43, P < 0·001). Varimax rotation generated three orthogonal components which we interpreted as intellectual performance, memory, and mood. Intellectual performance and self-reported mood were individually correlated with P3 latency, but memory was not (r = −0·36, P < 0·001; r = 0·23, P < 0·05; and r = −0·18, NS, respectively).Subjects with symptomatic HIV disease had a higher correlation between P3 latency and intellectual performance than subjects with asymptomatic HIV disease and, among patients with symptomatic HIV disease, poorer memory was associated with a lower CD4 count. Opiate or benzodiazepine consumption did not correlate with poor intellectual performance, memory, or selfrated mood in our sample. These results indicate that there is a relationship between AEP latency and neuropsychological measures of intellectual function, and that it is influenced by subjective mood. Surprisingly, declared current drug use has no discriminable effect on these relationships.

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confidence: 99%