HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

Achord, A.P.; Lewis, Robert E.; Brackin, Martha N.; Henderson, Harold; Cruse, Julius M.

doi:10.1159/000164049

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…Specific HLA‐DRB1 and HLA‐DQB1 alleles among Afro‐Americans and Caucasians have been shown to be associated with HIV infection (Odum et al. , 1990; Achord et al. , 1996).…”

Section: Introductionmentioning

confidence: 99%

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus‐infected patients of Mumbai, India

Shankarkumar

Pawar

Ghosh

et al. 2010

Int J Immunogenetics

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The pathogenesis of human immunodeficiency virus (HIV) infection clearly involves immunoregulatory host factors and products of major histocompatibility complex class II genes, which present antigenic peptides to the T-cell receptor on CD4+ cells, which in turn increase the production of specific antibodies and cytotoxic T lymphocytes. The main objective of this study was to determine the associations of human leucocyte antigen (HLA) DRB1 and DQB1 alleles and their haplotypes in 210 HIV-1-infected patients and compare them with 129 healthy normal individuals with same ethnic background. The HLA DRB1 and DQB1 alleles were genotyped using polymerase chain reaction product and sequence-specific probes for reverse line hybridization, analysed with the Invitrogen Dynal PMP software. Our results revealed a highly significant increase of HLA DRB1*0902 [odds ratio (OR) = 17.12; P = 0.004], DQB1*030103 (OR = 53.53; P = 4.61E-07) and DQB1*050201 (OR = 16.26; P = 0.0002) alleles while in contrast highly significant decrease in frequency of HLA DQB1*030101 (OR = 0.36; P = 0.0002), DQB1*050301 (OR = 0.22; P < 0.0001) and DQB1*060101 (OR = 0.43; P < 0.0001) among the HIV-1-infected patients when compared with the controls. The haplotype DRB1*0902-DQB1*030103 (OR = 10.65; P = 0.06) was significantly increased in HIV1 patients, while haplotypes DRB1*150101-DQB1*060101 (OR = 0.386, P < 0.0001), DRB1*030101-DQB1*020101 (OR = 0.197, P = 0.004) and DRB1*070101-DQB1*0202 (OR = 0.167, P = 0.001) were significantly decreased. Our results indicate clearly that there are HLA class II alleles involved in the susceptibility to and protection from HIV-1 infection in our study group and further they vary in different ethnic groups reported in literature.

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“…Specific HLA‐DRB1 and HLA‐DQB1 alleles among Afro‐Americans and Caucasians have been shown to be associated with HIV infection (Odum et al. , 1990; Achord et al. , 1996).…”

Section: Introductionmentioning

confidence: 99%

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus‐infected patients of Mumbai, India

Shankarkumar

Pawar

Ghosh

et al. 2010

Int J Immunogenetics

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“…Molecular methods identified an association between HLA-DQBl and susceptibility to HIV-1 infection [3]. Based on the epidemiological data, several HLA-DQBl subtypes were found in higher frequency in both African American and Caucasian HIV-l-positive patient popula tions when compared to HIV-1-negative regional controls.…”

Section: Introductionmentioning

confidence: 98%

“…In the Caucasian group, HLA class II antigens associated with HIV-1 infection were identified as HLA-DR10. HLA-DR12 (5), HLA-DQ6 (1) and HLA-DQ7 (3). HLA anti gens demonstrating a possible protective function among African Americans were Cw4 and DR6, whereas Cauca sians expressed none.…”

Section: Introductionmentioning

confidence: 99%

HLA-DQB1 Markers Associated with Human Immunodeficiency Virus Type I Disease Progression

Achord

Lewis²,

Brackin³

et al. 1997

Pathobiology

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In a previous investigation, we demonstrated that certain human leukocyte antigens (HLA) may be associated with human immunodeficiency virus type I (HIV-1) infection or protection from infection among regional African Americans and Caucasians. We demonstrated that HLA-DQB 1*0605 was associated with a possible increased risk of susceptibility to infection in African Americans and that DQB 1*0602 was associated with a possible increased risk of infection in Caucasians. The present study was designed to demonstrate possible HLA associations with HIV-1 disease progression and AIDS in regional African American and Caucasian populations. To differentiate rapid from slow progressors, immune parameters of the HIV-1-positive patient population were monitored over a mean follow-up period of 23 ± 2 months for African Americans (n = 30) and 25 ± 5 months for Caucasians (n = 22). To determine significance, HLA allele frequencies among rapid progressors were compared to those of slow progressors, separated by race. Results were analyzed by χ² analysis, with Fisher’s exact test where applicable, linear logistic regression and Kaplan-Meier survival analysis. In the HIV-1-positive African American group, a better prognosis was associated with HLA-DQB 1*0602. In the HIV-1-positive Caucasian group, HLA-DQB 1*0302 was associated with rapid HIV disease progression, but no marker was associated with a more favorable prognosis.

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“…Studies have shown that HLA class I and II genes were associated with susceptibility or resistance to HIV infection and disease progression . Among the HLA class II molecules, apart from HLA‐DR, specific HLA‐DQB1 and HLA‐DPB1 alleles have been shown to be associated with HIV infection . Flavivirus disease and its association with HLA molecules have been studied .…”

Section: Introductionmentioning

confidence: 99%

HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India

et al. 2013

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A sudden upsurge of fever cases with joint pain was observed in the outpatient department, Community Health Centre, Rangat during JulyAugust 2010 in Rangat Middle Andaman, India. The aetiological agent responsible for the outbreak was identified as chikungunya virus (CHIKV), by using RT-PCR and IgM ELISA. The study investigated the association of polymorphisms in the human leucocyte antigen class II genes with susceptibility or protection against CHIKV. One hundred and one patients with clinical features suggestive of CHIKV infection and 104 healthy subjects were included in the study. DNA was extracted and typed for HLA-DRB1 and DQB1 alleles. Based on the amino acid sequences of HLA-DQB1 retrieved from the IMGT/HLA database, critical amino acid differences in the specific peptide-binding pockets of HLA-DQB1 molecules were investigated. The frequencies of HLA-DRB1 alleles were not significantly different, whereas lower frequency of HLA-DQB1*03:03 was observed in CHIKV patients compared with the control population [P = 0Á001, corrected P = 0Á024; odds ratio (OR) = 0, 95% confidence interval (95% CI) 0Á0-0Á331; Peto's OR = 0Á1317, 95% CI 0Á0428-0Á405). Significantly lower frequency of glutamic acid at position 86 of peptidebinding pocket 1 coding HLA-DQB1 genotypes was observed in CHIKV patients compared with healthy controls (P = 0Á004, OR = 0Á307, 95% CI 0Á125-0Á707). Computational binding predictions of CD4 epitopes of CHIKV by NetMHCII revealed that HLA-DQ molecules are known to bind more CHIKV peptides than HLA-DRB1 molecules. The results suggest that HLA-DQB1 alleles and critical amino acid differences in the peptide-binding pockets of HLA-DQB1 alleles might have role in influencing infection and pathogenesis of CHIKV.

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HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

Cited by 14 publications

References 12 publications

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus‐infected patients of Mumbai, India

Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus‐infected patients of Mumbai, India

HLA-DQB1 Markers Associated with Human Immunodeficiency Virus Type I Disease Progression

HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India

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