Hiv-1 Drug Resistance Assessment in Pediatric Patients

Abstract

Twenty-one vertically HIV-1 infected children were assessed for drug resistance genotyping. Eighteen children presented at least one mutation conferring resistance to the nucleoside reverse transcriptase inhibitors, and seven children presented resistance to the non-nucleoside inhibitors. Among them, two children in whom the therapy had been discontinued two to three years before testing presented K101E, K103N, and G190A mutations conferring resistance to all the non-nucleoside drugs available for treatment. Protease gene mutations conferring resistance to at least two to up to twelve drugs were reported in 12 children. Studies in HIV-infected children have a particular meaning, and with antiretroviral therapy becoming more widely available, surveillance of viral resistance regional levels is relevant for treatment guidelines, supporting the rational use of antiretroviral drugs by treatment programs. Additional larger studies are still required to give more information on HIV-1 drug resistance in pediatric patients.

The art of surface modification of synthetic polymeric membranes

“…Simonetti309 described a process for the modification of porous polymeric materials {PVDF, polyvinylidene difluoride/polytetrafluoroethylene (PDF/PTFE) fuorocopolymer, PTFE, PP, PE, and PAN in the form of membranes, films, or porous webs} without the use of a free radical initiator by using acrylate monomers and UV light. The modified polymeric material exhibited new properties such as wettability and advantageous flow characteristics.…”