2024
DOI: 10.3389/fmicb.2024.1388729
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HIV-1 envelope facilitates the development of protease inhibitor resistance through acquiring mutations associated with viral entry and immune escape

Ntombikhona F. Maphumulo,
Michele L. Gordon

Abstract: IntroductionThere is increasing evidence supporting a role for HIV-1 envelope in the development of Protease Inhibitor drug resistance, and a recent report from our group suggested that Env mutations co-evolve with Gag-Protease mutations in the pathway to Lopinavir resistance. In this study, we investigated the effect of co-evolving Env mutations on virus function and structure.MethodsCo-receptor usage and n-linked glycosylation were investigated using Geno2Pheno as well as tools available at the Los Alamos se… Show more

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