HIV-1-Inhibiting Activity of the Essential Oil of<i>Ridolfia segetum</i>and<i>Oenanthe crocata</i>

Bicchi, Carlo; Rubiolo, Patrizia; Ballero, Mauro; Sanna, Cinzia; Matteodo, Maura; Esposito, Francesca; Zinzula, Luca; Tramontano, Enzo

doi:10.1055/s-0029-1185546

Cited by 47 publications

(29 citation statements)

References 17 publications

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“…The essential oil of Ridofolia segetum has been the main topic of many studies, based on the quantification of the main compounds of essential oils, chemical characterization studies, allowed the distinction of two types of HE; One is largely dominated by monoterpene hydrocarbons such as α-phelandrene, terpinolene and p-cymene (Bicchi and al., 2009, Fleisher and Fleisher, 1996, Marongiu and al., 2007, Palá-Paúl and al ., 2002, 2005; And the one which contains phenylpropanoids as main compounds or in large amounts, generally myristicin and dillapiol (Jannet and Mighri, 2007;Jabrane and al., 2010). The botanical identification of the species was carried out at the laboratory of Floristics of the Scientific Institute in Rabat.…”

Section: Introduction:-mentioning

confidence: 99%

Phytochemical Valuation of the Umbels of Ridolfia Segetum (L.) Moris of Morocco.

Karkouri¹,

Amalich²,

Drioiche³

et al. 2017

IJAR

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Section: Introduction:-mentioning

confidence: 99%

Phytochemical Valuation of the Umbels of Ridolfia Segetum (L.) Moris of Morocco.

Karkouri¹,

Amalich²,

Drioiche³

et al. 2017

IJAR

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“…Linalyl alcohol (18.9%) and 3-Cyclohexane-1-ol (13.58%) were their highest peak match, respectively (Tables 2 and 3). The inhibitory activities of the essential oil extracted from Ridolfia segetum , Oenanthe crocata and Santolina chamaecyparissus , with their chemical constituents comprising of β-Myrcene, Santolina triene and Limonene have been reported active against HIV-1 reverse transcriptase, human tumor, oxidant and inflammatory activities [12, 13]. Limonene itself has immune-stimulatory, analgesic and anaesthetic properties [14].…”

Section: Resultsmentioning

confidence: 99%

Phytomedical assessment of two Cymbopogon species found in Nkonkobe Municipality: toxicological effect on human Chang liver cell line

Omoruyi

Muchenje

2017

BMC Complement Altern Med

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Background Cymbopogon species are widely used as herbal remedies by the traditional healers living in Nkonkobe Municipality for the treatment and management of skin and respiratory infections. According to our survey, the plants seem to be very important because of the higher demands.MethodsThe leaves of C. validis and C. plurinodis were hydro-distilled and the resulted extracted oils were analyzed by GC/MS. Minimum inhibitory concentrations (MICs) ranging from 7.8 to 500.0 μg/ml of the extracted oils were tested against eight bacterial strains, using micro-well dilution method. The human Chang liver cell viability was determined using the CellTiter-Blue cell assay.ResultsGC-MS analysis of the C. validis essential oil amounted to 87.03%, major components identified were Linalyl alcohol (18.9%), 2-Nephthalenemethanol (6.67%), Longifolene (6.53%), Cubedol (6.08%). Total oil percentage of C. plurinodis was 81.47% and the main components were characterized as 3-Cyclohexane-1-ol (13.58%), Nerolidol (13.6%) and 2-Carene (12.6%). The essential oils from both plants were found to be active against the growth of Gram positive than the Gram negative bacterial tested. Lethal dose at 50 (LD50) of both plants showed 74.87 ± 1.41 and 81.66 ± 1.40 degree of toxicity at 24 h.ConclusionBoth plants extracts were toxic to human Chang liver cell lines.

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“…More precisely, kuwanon‐L inhibits RNase H function with an IC 50 value of 0.57 μ m and the RDDP function with an IC 50 value of 0.99 μ m . These results are very interesting and suggest that the natural product kuwanon‐L is able to inhibit different functions at the same time, in contrast with all other identified drugs and natural extracts that inhibit only one enzymatic function …”

Section: Figurementioning

confidence: 97%

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

et al. 2017

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In recent years many advances have been made in the fight against HIV-1 infection. However, the lack of a vaccine, together with the increasing resistance to the highly active anti-retroviral therapy (HAART), make HIV-1 infection still a serious global emergency. Thus, new compounds with original modes of action are continuously required, and natural products have ever been a very interesting class of pharmacologically active molecules. Some of them have been used since ancient times against viral infections. Here we present a work in which we suggest that kuwanon-L, a natural product active as an HIV-1 integrase (IN) inhibitor, might exert its overall antiviral activity through binding to multiple viral targets. Specific enzymatic tests, together with a time-of-addition (TOA) experiment, support our hypothesis of binding both to IN and to reverse transcriptase (RT). Overall, this compound can be considered an attractive lead for the development of new classes of antiviral agents able to overcome the problem of resistance, due to its ability to exert its action by binding simultaneously to multiple viral targets.

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HIV-1-Inhibiting Activity of the Essential Oil ofRidolfia segetumandOenanthe crocata

Cited by 47 publications

References 17 publications

Phytochemical Valuation of the Umbels of Ridolfia Segetum (L.) Moris of Morocco.

Phytochemical Valuation of the Umbels of Ridolfia Segetum (L.) Moris of Morocco.

Phytomedical assessment of two Cymbopogon species found in Nkonkobe Municipality: toxicological effect on human Chang liver cell line

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

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