HIV-1 Integrase Inhibition of Biscoumarin Analogues

Su, Chang‐Xiao; Mouscadet, Jean‐François; Chiang, Chih‐Chia; Tsai, Hou-Jen; Hsu, Ling-Yih

doi:10.1248/cpb.54.682

Cited by 76 publications

(27 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also represents the core structure of several molecules of pharmaceutical importance. Coumarin has been reported to serve as anti-cancer [2], anti-microbial [3], anti-inflammatory [4] and anticoagulant [5]. These pharmacological properties of coumarin encouraged us to synthesize some coumarin derivatives.…”

Section: Introductionmentioning

confidence: 99%

Grinding technique for the tandem synthesis of bis coumarinyl methanes using [BDBDMIm]Br-CAN

Nikpassand¹,

Fekri²,

Sahrapeima³

2017

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. 3,3-(Butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium)bromide ([BDBDMIm]Br) is easily used as an efficient and recyclable ionic liquid for the synthesis of bis coumarinyl methanes in the presence of a catalytic amount of ceric ammonium nitrate (CAN) under grinding. All reactions are performed in the absence of solvent in excellent yield during short reaction time. Furthermore, the ionic liquid can be reused and recovered for several times without loss of activity. This method provides several advantages such as simple work-up, environmental friendliness and shorter reaction time along with high yields. All of synthesized compounds were characterized by infrared spectroscopy, 1 H and 13 C nuclear magnetic resonance spectroscopy and elemental analyses.

show abstract

Section: Introductionmentioning

confidence: 99%

Grinding technique for the tandem synthesis of bis coumarinyl methanes using [BDBDMIm]Br-CAN

Nikpassand¹,

Fekri²,

Sahrapeima³

2017

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

show abstract

“…17 Dicoumarol also potentiates cisplatin-induced apoptosis urogenital cancer cell lines. 18 Dicoumarol and its derivatives display wide range of pharmacological activity such as anti-HIV, 19,20 antibiotic, 21 antitumor and anti-inflammatory. 22 Dicoumarols are generally synthesized by cascade reaction of two equivalents of 4-hydroxycoumarin and different aldehydes.…”

Section: Introductionmentioning

confidence: 99%

Fast highly efficient 'on-solvent' non catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes

Elinson¹,

Vereshchagin²,

Sokolova³

et al. 2017

Arkivoc

View full text Add to dashboard Cite

Non-catalytic cascade reaction of benzaldehydes and two equivalents of 4-hydroxycoumarin initiated by reflux in propanol results in the fast (15 min) and efficient formation of substituted tetrahydro-1H-xanthen-1-ones in 93-98% yields. The developed fast cascade approach to the substituted bis(4-hydroxycoumarinyl)arylmethanes, which are known as medicinally relevant substances with anti-HIV, antibiotic, anti-inflammatory and anti-cancer activity, is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast, efficient and environmentally benign synthetic concept for cascade reactions strategy.

show abstract

“…Biscoumarins are a large group of heterocycles with diverse, interesting and important biological and pharmaceutical activities [1][2][3][4][5] activities. In recent years and because of these important activities, several methods are reported for the synthesis of biscoumarins using a variety of catalysts and reagents [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Introduction of W-doped ZnO nanocomposite as a new and efficient nanocatalyst for the synthesis of biscoumarins in water

et al. 2015

View full text Add to dashboard Cite

W-doped ZnO nanocomposite (W-ZnO) is easily prepared and characterized using a variety of techniques including XRD, TEM, BET, ICP-OES and SEM. This reagent can be used as an efficient and heterogeneous catalyst for the preparation of biscoumarins in water under mild conditions. Easy preparation of the catalyst, mild reaction conditions, easy work-up procedure, excellent yields and short reaction times are some of the advantages of this work. In addition, in this article and for the first time, the preparation of biscoumarins from the protected derivatives of aldehydes including oximes, hydrazones and 1,1-diacetates is reported.

show abstract

HIV-1 Integrase Inhibition of Biscoumarin Analogues

Cited by 76 publications

References 12 publications

Grinding technique for the tandem synthesis of bis coumarinyl methanes using [BDBDMIm]Br-CAN

Grinding technique for the tandem synthesis of bis coumarinyl methanes using [BDBDMIm]Br-CAN

Fast highly efficient 'on-solvent' non catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes

Introduction of W-doped ZnO nanocomposite as a new and efficient nanocatalyst for the synthesis of biscoumarins in water

Contact Info

Product

Resources

About