HIV-1 Nomenclature Proposal

Robertson, DL; Jp, Anderson; Bradac, James; Carr, JK; Foley, Brian; Funkhouser, RK; Gao, Feng; Hahn, BH; Ml, Kalish; Kuiken, Carla; Learn, GH; Leitner, Thomas; McCutchan, Francine E.; Osmanov, Saladin; Peeters, Martine; Pienia̧źek, Danuta; Salminen, Mika; Sharp, Paul M.; Wolinsky, Steven M.; Korber, Bette T.

doi:10.1126/science.288.5463.55d

Cited by 814 publications

(649 citation statements)

References 8 publications

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“…15 The breakpoints identified in 11SG.HM021, 11SG.HM062, and 11SG.HM091 are identical among the three samples but were distinct from the four CRF01_AE/B CRFs described to date in Thailand and Malaysia (Fig. 1).…”

Section: -14mentioning

confidence: 97%

Identification of New CRF51_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates

Eyzaguirre

Carr³

et al. 2012

AIDS Research and Human Retroviruses

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A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

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Section: -14mentioning

confidence: 97%

Identification of New CRF51_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates

Eyzaguirre

Carr³

et al. 2012

AIDS Research and Human Retroviruses

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“…Group M is the predominant circulating HIV-1 group. It has been divided into the current nine subtypes: A-D, F-H, J, and K. 15,16 HIV-2 is another strain of HIV that is less common. HIV-2 is predominantly found in Western Africa.…”

Section: Introductionmentioning

confidence: 99%

Impact of HIV Subtype on Performance of the Limiting Antigen-Avidity Enzyme Immunoassay, the Bio-Rad Avidity Assay, and the BED Capture Immunoassay in Rakai, Uganda

Longosz

Serwadda

Nalugoda

et al. 2014

AIDS Research and Human Retroviruses

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Previous studies demonstrated that individuals with subtype D HIV infection who had been infected for 2 or more years were frequently misclassified as assay positive using cross-sectional incidence assays. Samples from 510 subjects (212 subtype A, 298 subtype D) who were infected for 2.2 to 14.5 years (median 5.4 years) and were not virally suppressed were tested using an LAg-Avidity enzyme immunoassay (LAg-Avidity EIA), Bio-Rad Avidity assay, and BED capture enzyme immunoassay (BED-CEIA). The performance of these three assays was evaluated using various assay cutoff values [LAg-Avidity EIA: < 1.0 OD-n and < 2.0 OD-n; Bio-Rad Avidity assay: < 40% avidity index (AI) and < 80% AI; BED-CEIA: < 0.8 OD-n]. The mean LAg-Avidity EIA result was higher for subtype A than D (4.54 -0.95 vs. 3.86 -1.26, p < 0.001); the mean Bio-Rad Avidity assay result was higher for subtype A than D (88.9% -12.5% vs. 75.1 -30.5, p < 0.001); and the mean BED-CEIA result was similar for the two subtypes (2.2 -1.2 OD-n for subtype A, 2.2 -1.3 OD-n for subtype D, p < 0.9). The frequency of misclassification was higher for individuals with subtype D infection compared to those with subtype A infection, using either the LAg-Avidity EIA with a cutoff of < 2.0 OD-n or the Bio-Rad Avidity assay with cutoffs of < 40% or < 80% AI. No subtype-specific differences in assay performance were observed using the BED-CEIA. Sex and age were not significantly associated with misclassification by any assay. The LAg-Avidity EIA with a cutoff < 1.0 OD-n had the lowest frequency of misclassification in this Ugandan population.

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“…1 URFs may give rise to CRFs if transmission becomes widespread and sustained in the population. 1,4 As the epicenter of HIV-1 transmission in China, the southwestern province of Yunnan is considered to be one such recombination hotspot. Over the past 20 years, many HIV-1 strains with different genotypes (B, C, CRF07_BC, CRF08_BC, CRF01_AE, and diverse patterns of URFs) were found in Yunnan.…”

mentioning

confidence: 99%

“…The recombinant structure of the new CRF is distinct from any known CRFs. Since the CRF consists of contributions from three different subtypes, it is designated CRF65_cpx (complex), 4 and is the first complex CRF identified in China.…”

mentioning

confidence: 99%

Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF65_cpx) Composed of CRF01_AE and Subtypes B and C in Western Yunnan, China

Feng

Wei

Hsi

et al. 2014

AIDS Research and Human Retroviruses

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HIV-1 Nomenclature Proposal

Cited by 814 publications

References 8 publications

Identification of New CRF51_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates

Identification of New CRF51_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates

Impact of HIV Subtype on Performance of the Limiting Antigen-Avidity Enzyme Immunoassay, the Bio-Rad Avidity Assay, and the BED Capture Immunoassay in Rakai, Uganda

Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF65_cpx) Composed of CRF01_AE and Subtypes B and C in Western Yunnan, China

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