HIV-1 with Predicted CXCR4 Genotype Identified in Clade C from India

Kandathil, AJ; Kannangai, Rajesh; Abraham, O C; Pulimood, Susanne; Jensen, Mark A.; Sridharan, Gopalan

doi:10.1007/bf03256311

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Both patients harboring probable X4-tropic virus were diagnosed with HIV-1 infection for longer than 5 years. Two previous reports of X4-tropic HIV-1 subtype C viruses from India have not commented on the length of infection [ 19 , 20 ]. The presence of X4-tropic strains is well known to be significantly associated with longer duration of HIV infection [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…While X4-tropic HIV-1 subtype C strains have been widely reported from Africa [ 14 - 16 ], the presence of CXCR4 as a co-receptor to facilitate entry into the host cell is uncommon among Indian subtype C strains [ 17 , 18 ]. R5-tropic viruses constitute by far the predominant strains in India although recent reports indicate the occasional presence of HIV-1 subtype C X4-tropic strains [ 19 - 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India

et al. 2010

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BackgroundUnderstanding co-receptor tropism of HIV-1 strains circulating in India will provide key analytical leverage for assessing the potential usefulness of newer antiretroviral drugs such as chemokine co-receptor antagonists among Indian HIV-infected populations. The objective of this study was to determine using in silico methods, HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences.ResultsR5-tropism was seen in 96.8% of a total of 1045 HIV-1 subtype C Indian sequences. Co-receptor prediction of 15 primary clinical isolates detected two X4-tropic strains using the C-PSSM matrix. R5-tropic HIV-1 subtype C V3 sequences were conserved to a greater extent than X4-tropic strains. X4-tropic strains were obtained from subjects who had a significantly longer time since HIV diagnosis (96.5 months) compared to R5-tropic strains (20.5 months).ConclusionsHigh prevalence of R5 tropism and greater homogeneity of the V3 sequence among HIV-1 subtype C strains in India suggests the potential benefit of CCR5 antagonists as a therapeutic option in India.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India

et al. 2010

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“…8,9 CXCR4 usage in subtype C viruses is rarely observed even in advanced stages of infection. 10,11 This patient has been on antiretroviral therapy for the past 4 years, with a very low CD4 count and high viral load ( Table 1). The envelope sequence of the virus infecting another patient (AIIMS_375) was also predicted to be showing CXCR4 usage by the Web PSSM program, while with Geno2pheno CCR5 usage was predicted.…”

Section: Prakash Et Almentioning

confidence: 99%

Diversity of HIV Type 1 Envelope (V3-V5) Sequence in HIV Type 1-Infected Indian Children

Prakash

Kalra

Lodha

et al. 2012

AIDS Research and Human Retroviruses

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We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.

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HIV-1 Coreceptor Tropism in India

Gupta¹,

Neogi

Srinivasa³

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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The predominance of R5-tropism in Indian HIV-1C strains despite a marginal temporal increase in X4-tropism prevalence highlights the likely effectiveness of coreceptor antagonists in India. Our frequent observation of common maraviroc resistance-associated substitutions among Indian R5-tropic HIV-1C raises the possibility that they may be natural polymorphisms, indicating the need for further elucidation.

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HIV-1 with Predicted CXCR4 Genotype Identified in Clade C from India

Abstract: We report, for the first time, CXCR4-using strains among HIV-1 clade C strains circulating in India.

Cited by 3 publications

References 14 publications

Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India

Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India

Diversity of HIV Type 1 Envelope (V3-V5) Sequence in HIV Type 1-Infected Indian Children

HIV-1 Coreceptor Tropism in India

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