HIV, which causes AIDS, has infected millions of women, men and children in developed and developing countries. It is noticed that second most serious transmission mode of HIV is the use of unsterilized needles. If one user has HIV, the small amount of blood, which he or she leaves in the needle or syringe, and the same is used for the next user then this small amount of blood goes into the bloodstream of the user, who may also get HIV. This mode involves many complexities due to the magnitude and extent of the needles used by persons of all age groups. The present study is focused on the simple stochastic model for spreading the HIV virus through needle-sharing. The aim of this study is to determine the probability of HIV infection due to the use of clinical injections by using stochastic techniques as well as by neuro-fuzzy approach. The analytical expression for the probability of needle infection is derived. The analytical results are compared with results obtained by neuro-fuzzy techniques.