HIV/AIDS treatment failure and associated factors in Ethiopia: Meta-analysis

Abstract

Background: The national burden of HIV treatment failure and associated factors in Ethiopian context is required to provide evidence towards a renewed ambitious future goal.Methods: We accessed Ethiopian Universities’ online repository library, Google Scholar, PubMed, Web of Science, and Scopus to get the research articles. We run I-squared statistics to see heterogeneity. Publication bias was checked by using Egger’s regression test. The pooled prevalence was estimated using DerSimonian-Laird random-effects model. We employed the sensitivity analysis to see the presence of outlier result in the included studies. Results: The overall HIV treatment failure was 15.9% (95% CI: 11.6%-20.1%). Using immunological, virological, and clinical definition, HIV treatment failure was 10.2% (6.9%-13.6%), (5.6% (95% CI: 2.9%-8.3%), and (6.3% (4.6%-8.0%)), respectively. The pooled effects of WHO clinical stage III/IV (AOR=1.9; 95% CI: 1.3-2.6), presence of opportunistic infections (AOR=1.8; 95% CI: 1.2-2.4), and poor HAART adherence (AOR= 8.1; 95% CI: 4.3-11.8) on HIV treatment failure were estimated. Conclusions : HIV treatment failure in Ethiopia found to be high. HIV intervention programs need to address the specified contributing factors of HIV treatment failure. Behavioral intervention to prevent treatment interruption is required to sustain HIV treatment adherence. Protocol Registration : It has been registered in the PROSPERO database with a registration number of CRD42018100254.