HIV and hepatitis C co-infection in Europe, Israel and Argentina: a EuroSIDA perspective

Uptake of Tenofovir-Based Antiretroviral Therapy among HIV–HBV-Coinfected Patients in the EuroSIDA Study

“…Baseline characteristics of included persons were summarized using proportions or medians and interquartile ranges (IQR). Regions of Europe were classified as in previous studies [12]. Argentina was excluded from analyses.…”

Implementation of Occult Hepatitis Screening in the Spanish Cohort of HIV-infected Pediatric Patients

“…18,786 patients, a quarter of the deaths in a ten-year period were attributable to HCV infection (17,33). Triple coinfection with HIV, HBV and HCV has also been described, the most frequent HCV superinfection being of a chronic HBsAg carrier in whom HBV DNA is usually low or undetectable, although it can fluctuate over time, and the determinant of the severity of the progression of liver disease is HCV infection (25).…”

“…Moreover, HCV/HIV coinfection is known to confer risk for other non-liver related events like insulin-resistance, chronic kidney disease, hematological malignancies and neurocognitive disorders (4,7,(13)(14)(15)(16)(17)(18)(19).…”

Natural history of liver disease and effect of hepatitis C virus on HIV disease progression

“…Depending on the transmission route of HIV infection, coinfection prevalences differ strongly, with people who inject drugs and people from high-prevalence countries for both viruses being the most affected. In Eastern Europe, where intravenous drug use is the main driver of the HIV epidemic, HCV antibody prevalences of more than 50% of the HIV-infected population have been described [10]. Also for more than a decade an ongoing epidemic of acute hepatitis C infection has been observed in HIV-positive men who have sex with men (MSM) especially in urban centres in Europe, Australia, and the USA [11,12], where HCV transmission occurs in the setting of high-risk sexual behaviour and recreational drug use.…”