The aim of this article is to describe and critically discuss the discourse on HIV/AIDS within the framework of Islamic Religious Education (IRE) in Kisumu, Kenya. It is based on data collected mainly through participant observation and interviews during five fieldwork sessions in the period 20032006. The context is the research project Islamic education and social development in Kisumu, Kenya, financed by the Swedish International Development Agency (SIDA). The article describes how the issue of HIV/AIDS is present in the context of IRE, mainly in secondary schools in Kisumu, an area heavily affected by the pandemic. The framework in which teachers and students address the issue is one conditioned by notions of religiously correct and incorrect sexual behaviour and gender, and by the fact that Muslims constitute a religious minority in Kisumu. The article argues that the main role of the local discourse on HIV/AIDS and Islam in the context of IRE is to strengthen notions of religious and moral superiority, and hence boost the self-esteem of the Muslim students. Furthermore, it provides support for dominant views and norms relating to Islam, gender and sexuality.