HIV and the Antiviral Role of Mushroom Nutraceuticals

Fernandes, Tito; Chaquisse, Eusébio; Ferrão, Jorge

doi:10.14738/aivp.83.8650

Cited by 5 publications

(3 citation statements)

References 107 publications

(135 reference statements)

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“…Similarly, compounds detected in L. squarrosulus, A. auricular-judae, P. ostreatus and V. volvacea has pedigree of antiviral activities against Human Immune Deficiency Virus (HIV) virus while A. auricular-judae, M. copelandii, B. myosura, P. ostreatus and V. volvacea synthesizes compounds with anticancer, cancer preventive, antitumor and anti-inflammatory activities. This suggests the potential of these mushrooms in foiling infectious diseases caused by viruses [28]- [31], as well as an immunomodulators in cancer immunotherapy and anti-hyperplasia and hypertrophic cell growth [32]- [34]. Similarly, the presences of Undecane; Noxiptiline and 9,17-Octadecadienal, (Z) with reported antimicrobial activities in M. copelandii and V. volvacea, reveals the potential of this species as a source of probiotic compounds in the management of infectious disease [25], [35], [36].…”

Section: Discussionmentioning

confidence: 97%

GC-MS Analysis of Bioactive Compounds in Some Wild-Edible Mushrooms from Calabar, Southern Nigeria

Oni

Akomaye

Markson

et al. 2020

EJBIO

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Studies to exploit wild mushrooms as a source of biologically active compounds are gaining importance in the recent years. In that view, the present study was carried out to evaluate the bioactive compounds of six wild edible mushrooms: Lentinus squarrosulus Mont., Auricularia auricular-judae (Bull.) Wettst., Mycetinis copelandii (Desjardin) A.W. Wilson & Desjardin, Baeospora myosura (Fr.) Singer, Pleurotus ostreatus (Jacq. ex. fr) Kummer and Volvariella volvacea (Bull. ex. Fr.) Singer. The specimen was subjected to phytochemical screening using gas chromatography mass spectrometer (GCMS) with the view to identify the important volatile constituents. The dried sporocarp was subjected to methanol extraction using a Soxhlet extractor and rotatory evaporator. This led to the identification of 14, 26, 33, 5, 49 and 32 different compounds in L. squarrosulus, A. auricular-judae, M. copelandii, B. myosura, P. ostreatus and V. volvacea respectively. n-Hexadecanoic acid; 9,12-Octadecadienoic acid (Z,Z)- and 2(3H)-Furanone where the most frequently occurring compounds across the studied mushrooms. The identified compound reportedly shows diverse bioactive activities, including antiviral, anticancer, antimicrobial, antioxidant, hypocholesterolemic, anaphylactic, narcotic, neurostimulant, emollient, expectorant, laxative, pesticidal, insecticidal and insectifugal activities. This data may provide baseline information about the bioactive constituents of these species from Nigeria, in providing valuable compounds of substantial medicinal and agricultural importance.

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Section: Discussionmentioning

confidence: 97%

GC-MS Analysis of Bioactive Compounds in Some Wild-Edible Mushrooms from Calabar, Southern Nigeria

Oni

Akomaye

Markson

et al. 2020

EJBIO

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“…Also, 6-Ethyl-5,6-dihydro-2H-pyran-2-one and 5,6-Diphenyl-4,5-dihydro-1,2,4-triazin-3(2H)-one detected in D. concentrica has been reported to possess antiviral activities against Human Immune Deficiency Virus (HIV) virus whereas all the study mushrooms except T. versicolor, synthesizes compounds with cancer-preventive, antitumor and anti-inflammatory activities. This suggests the potential of these mushrooms and their products in foiling infectious diseases caused by viruses [51]- [54], as well as an immunomodulator in cancer immunotherapy and antihyperplasia, and hypertrophic cell growth [55]- [57].…”

Section: Discussionmentioning

confidence: 98%

Amino Acid Profiles and Bioactive Compounds of Four Inedible Mushrooms from Oban Division of Cross River National Park (CRNP), Nigeria

Oni

Akomaye

Umana

et al. 2021

EJBIO

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Inedible mushrooms are endowed with diverse nutritional and nutraceutical compounds. In this study, the amino acid profile, and phytochemical fingerprints of four selected wild inedible mushroom species from Oban Division of Cross River National Park (CRNP), Nigeria including Crepidotus applanatus (Pers.) P. Kumm, Daldinia concentrica (Bolton) Cesati & de Notaris, Oxyporus populinus (Schumach.) Donk and Trametes versicolor (L.) Lloyd were investigated. The fresh sporocarps of study mushroom were collected from the decaying wood during July 2018. Samples for amino acids profiling were dried to constant weight, defatted, hydrolyzed, evaporated in a rotary evaporator and loaded into the cartridge of the Applied Biosystems PTH Amino Acid Analyzer and analyzed for 45 minutes. The samples for phytochemical analysis were subjected to methanol extraction using a Soxhlet extractor and rotatory evaporator and injected into the column of an Agilent gas chromatography mass spectrometer (GCMS). The results of amino acid analysis revealed the presence of ten essential and eight non-essential amino acids in varying quantities across the species. The total amino acid content was highest in C. applanatus followed by D. concentrica, T. versicolor, and O. populinus in decreasing order. Glutamic acid, Arginine, and Aspartic acid were present in the highest amounts while Cystine, Lysine, and Histidine were the least across the species. The phytochemical screening of the samples led to the identification of 24 different compounds in D. concentrica, six compounds each in C. applanatus and O. populinus and three compounds in T. versicolor. In terms of percentage composition, 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, ethyl ester, 1-Methylbicyclo[3.2.1]octane, Acetamide, N-(6-acetylaminobenzothiazol-2-yl)-2-(adamantan-1-yl)- and 9,19-Cyclolanost-24-en-3-ol, (3.beta.)-,TMS derivative were the most dominant compounds in C. applanatus, D. concentrica and T. versicolor respectively. The identified compound reportedly shows diverse bioactive activities, including antiviral, anticancer, antioxidant, hypocholesterolemic, anaphylactic, neurostimulant, pesticidal, insecticide and insecticidal activities. This data may represent the baseline information on the amino acid profiles and bioactive constituents of inedible mushroom species from Nigeria, as sources of noble compounds of substantial nutritional, medicinal and agricultural importance.

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“…We have previously reviewed this subject [134], and the pathogenesis of the disease is considered multifactorial. Nutrition is a fundamental part of a comprehensive package of care for people living with HIV/AIDS, and mushrooms supply bioactive molecules that may help patients [110].…”

Section: Hiv/aidsmentioning

confidence: 99%

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

et al. 2021

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The defining characteristics of the traditional Sub-Saharan Africa (SSA) cuisine have been the richness in indigenous foods and ingredients, herbs and spices, fermented foods and beverages, and healthy and whole ingredients used. It is crucial to safeguard the recognized benefits of mainstream traditional foods and ingredients, which gradually eroded in the last decades. Notwithstanding poverty, chronic hunger, malnutrition, and undernourishment in the region, traditional eating habits have been related to positive health outcomes and sustainability. The research prevailed dealing with food availability and access rather than the health, nutrition, and diet quality dimensions of food security based on what people consume per country and on the missing data related to nutrient composition of indigenous foods. As countries become more economically developed, they shift to “modern” occidental foods rich in saturated fats, salt, sugar, fizzy beverages, and sweeteners. As a result, there are increased incidences of previously unreported ailments due to an unbalanced diet. Protein-rich foods in dietary guidelines enhance only those of animal or plant sources, while rich protein sources such as mushrooms have been absent in these charts, even in developed countries. This article considers the valorization of traditional African foodstuffs and ingredients, enhancing the importance of establishing food-based dietary guidelines per country. The crux of this review highlights the potential of mushrooms, namely some underutilized in the SSA, which is the continent’s little exploited gold mine as one of the greatest untapped resources for feeding and providing income for Africa’s growing population, which could play a role in shielding Sub-Saharan Africans against the side effects of an unhealthy stylish diet.

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HIV and the Antiviral Role of Mushroom Nutraceuticals

Cited by 5 publications

References 107 publications

GC-MS Analysis of Bioactive Compounds in Some Wild-Edible Mushrooms from Calabar, Southern Nigeria

GC-MS Analysis of Bioactive Compounds in Some Wild-Edible Mushrooms from Calabar, Southern Nigeria

Amino Acid Profiles and Bioactive Compounds of Four Inedible Mushrooms from Oban Division of Cross River National Park (CRNP), Nigeria

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

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