HIV-associated eosinophilic folliculitis: Diagnosis by transverse histologic sections

Transverse sectioning in the evaluation of skin biopsy specimens from alopecic dogs

“…In human medicine, transverse skin sections have facilitated the diagnosis of HIV‐associated eosinophilic folliculitis (Piantanida et al . 1998), and Fox‐Fordyce disease (characterised by a keratotic plug at the follicular orifice and spongiosis of the infundibular epithelium at the level of entry of the apocrine duct) (Stashower et al . 2000).…”

“…This study also highlights the value of transverse sectioning in the diagnosis of diseases where key features may involve only limited numbers of the adnexa. In human medicine, transverse skin sections have facilitated the diagnosis of HIV-associated eosinophilic folliculitis (Piantanida et al 1998), and Fox-Fordyce disease (characterised by a keratotic plug at the follicular orifice and spongiosis of the infundibular epithelium at the level of entry of the apocrine duct) (Stashower et al 2000). Transverse sections were also of particular value in creating a wider definition of the features of chronic cutaneous lupus erythematosus (Chung & Goldberg 2017).…”

Diseases of cutaneous appendages

“…235 Another case was associated with pathergy. 231,[245][246][247][248][249][250][251][252][253] It differs from the classic form (Ofuji's disease) by the severe pruritus, the absence of circinate and palmoplantar lesions, and the less frequent involvement of the face. 237 The etiology of eosinophilic pustular folliculitis is unknown.…”

Eosinophilic pustular folliculitis: A 40 year retrospect

“…8,15 In IS-EPF, CD8 1 lymphocytes in a predominance of 10:1 may be observed and, rarely, follicular eosinophilic abscesses and sebaceous gland lysis. 15,22 Although careful serial biopsy sectioning ensures adequate identification of characteristic folliculocentric findings in EPF, it is often difficult to demonstrate these changes in IS-EPF. In fact, some question whether all IS-EPF cases are truly centered about follicular units and whether it should be re-termed eosinophilic dermatitis.…”

“…We find that serial and transverse sectioning offers more comprehensive analysis of every hair follicle in the biopsy specimen, facilitating easier identification of folliculitis findings and allowing a clear-cut diagnosis. 15,22 ''Follicular mucinosis,'' a reaction pattern associated with lupus erythematosus, photodermatoses, arthropod bites, Hodgkin's disease, and angiolymphoid hyperplasia in addition to EPF, may be seen as mucinous degeneration of the sebaceous glands and outer follicular sheath in as many as 40% of EPF cases. 8,23,24 However, the term ''epithelial mucinosis'' is more appropriate as the mucin is rarely associated with follicles.…”