HIV‐associated lymphoepithelial cysts and lesions: morphological and immunohistochemical study of the lymphoid cells

Abstract

It is postulated that this finding is due to the HIV causing down-regulation of bcl-2 protein.

Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases

“…Thus, there has been increasing awareness that LE cysts have been paid more attention to in terms of their relationship to HIV. However, the relationship between HIV infection and LE cysts still remains controversial because there are HIV-negative patients with LE cysts [9,10].…”

Cystic lymphoid hyperplasia: an orofacial lesion strongly associated with HIV and AIDS

“…The incidence of CLH in HIV‐infected children is reported to be approximately 1–10%, with male predominance, although one study showed a higher incidence in females . Similar to adults, paediatric patients in this study [6–10 years (mean, 7.8 years; median, 8 years)] showed no gender bias ( n = 6; male = female), which is comparable to the study by Dave et al .…”

“…[2][3][4] Lymphoepithelial cysts are a distinct clinicopathological entity characterized by single or multiple cysts lined by epithelial and lymphoid cells, arising frequently in the parotid glands of HIV-infected patients. [5][6][7] This entity has been described using various terms, such as Sj€ ogren-like syndrome, 8 benign lymphoepithelial lesion (BLEL) 7,9 or cyst, 10 cystic lymphoepithelial lesion, 11 HIV salivary gland disease 12 and lymphoepithelial cysts (LECs). 13,14 We use the term 'cystic lymphoid hyperplasia' (CLH) to describe the benign lymphoepithelial cystic lesions (BLEC) occurring in the salivary glands of HIV-positive individuals; a term first used in the French literature by Vaillant et al 15 to describe parotid gland enlargement in two AIDS patients, and earlier by Ryan et al, 16 who recognized this as a peculiar AIDS-related pattern of peripheral lymphadenopathy within salivary gland lymph nodes.…”

HIV disease presenting as a unilateral parotid gland swelling

“…8 The T cell population within the cyst has been found to be CD8 positive and CD4 negative. 9 The transient expansion of the CD8+ T cell pool normally occurs in the early phase of HIV infection. However, persistent expansion of this pool is observed, and it is related to two settings: diffuse infiltrative lymphocytic syndrome (DILS) and HIV associated CD8+ lymphocytosis syndrome.…”