HIV care in Central and Eastern Europe: How close are we to the target?

Gökengin, Deniz; Oprea, Cristiana; Begovać, Josip; Horban, Andrzéj; Zeka, Arzu Nazlı; Sedláček, Dalibor; Allabergan, Bayjanov; Almamedova, Esmira A.; Balayan, Tatevik; Bánhegyi, Dénes; Bukovinova, P; Chkhartishvili, Nikoloz; Damira, Alymbaeva; Deva, Edona; Elenkov, Ivaylo; Gashi, Luljeta; Gexha-Bunjaku, Dafina; Hadciosmanovic, Vesna; Harxhi, Arjan; Holban, Tiberiu; Jevtovic, Djorje; Jilich, David; Kowalska, Justyna D.; Kuvatova, Djhamal; Ладная, Н. Н.; Mamatkulov, Adkhamjon; Marjanović, Aleksandra; Nikolova, Maria; Poljak, Mario; Rüütel, Kristi; Shunnar, Azzaden; Stevanović, Milena; Trumova, Zhanna; Yurin, Oleg

doi:10.1016/j.ijid.2018.03.007

Cited by 48 publications

(66 citation statements)

References 20 publications

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“…In our study only 12 out of 20 centres had access to the drug, all of which are high-income or upper-middle income countries. There seems to be no improvement over time, as similarly in a study from 2015 including 24 countries from the Eastern and Central Europe, DTG was available in half, RAL in 70%, and elvitegravir fixed-dose combination only in 20% and again the majority (75%) was high or upper-middle income countries [8]. The relatively high number of women exposed to DTG in our study, is an indicator that DTG has become a preferable antiretroviral drug in the region.…”

Section: Discussionmentioning

confidence: 93%

Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

et al. 2019

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Objectives:The purpose of this study was to investigate dolutegravir (DTG) use among women and exposure to DTG during pregnancy in real world in Central and Eastern Europe and neighboring countries. Material and methods:Centres from 20 countries included in the Euroguidelines in Central and Eastern Europe (ECEE) Network and Finland were asked to complete an on-line questionnaire.Results: Seven centres from Czech Republic, Finland, Greece, Poland, Slovakia, and Turkey provided detailed information. DTG exposure was reported in 415 women, of which 26 were during pregnancy. Of those, 22 were on DTG at the time of conception and 4 had started DTG during pregnancy. Few women had conventional risk factors. The data on folic acid usage was unknown for eight women; 14 were using and four were not using folic acid. Four pregnancies were ongoing at the time of the study and of those with an outcome, 77.3% resulted with term, 13.6% preterm delivery, 4.5% spontaneous and 4.5% medical abortion. Conclusions:The DTG signal report indicates the importance of safety research for drug use in pregnancy and highlights the urgent need for systematic surveillance of pregnancy outcomes and neonatal surveillance. Countries with low-or moderate HIV prevalence should be included in studies reviewing pregnancy outcomes and in any surveillance system to ensure the accuracy of drug safety revision.

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Section: Discussionmentioning

confidence: 93%

Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

et al. 2019

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“…The first two regions have the biggest number of tourism activity in Turkey*. Marmara Region has almost the largest Syrian and African refugee populations and it is next to Eastern Europe where the number of HIV and syphilis patients are increasing (24). On the other hand, Black Sea Region is adjacent to the Russian/Caucasian territory where the population of HIV and syphilis patients increased in 2017 as well (24).…”

Section: Discussionmentioning

confidence: 99%

“…Marmara Region has almost the largest Syrian and African refugee populations and it is next to Eastern Europe where the number of HIV and syphilis patients are increasing (24). On the other hand, Black Sea Region is adjacent to the Russian/Caucasian territory where the population of HIV and syphilis patients increased in 2017 as well (24). The relationship between these regions is tourism and commercial, so there is a lot of human traffic between these regions (25).…”

Section: Discussionmentioning

confidence: 99%

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Sarıgül¹,

Sayan

İnan

et al. 2019

Cent Eur J Public Health

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Objective: Treponema pallidum and HIV are transmitted frequently through sexual contact, these agents with epidemiological similarities coinfect the same host. The current number of HIV-infected cases in Turkey is increasing. For this reason, we aimed to reveal the characteristics of syphilis in HIV/AIDS cases. Methods: A retrospective longitudinal cohort study was performed, patients were followed up at 24 clinics in 16 cities from all seven regions of Turkey between January 2010 to April 2018. We examined the socio-demographic characteristics, laboratory parameters and neurosyphilis association in HIV/AIDS-syphilis co-infected cases. Results: Among 3,641 patients with HIV-1 infection, 291 (8%) patients were diagnosed with syphilis co-infection. Most patients were older than 25 years (92%), 96% were males, 74% were working, 23% unemployed, and 3% were students. The three highest prevalence of syphilis were in Black Sea (10.3%), Mediterranean (8.4%) and Marmara Regions (7.4%). As for sexual orientation, 46% were heterosexuals, 42% men who have sex with men (MSM), and no data available for 12%. Patients with the number of CD4+ ≤ 350 mm 3 reached 46%, 17% of the patients received antiretroviral therapy and neurosyphilis association reached 9%. Conclusion: Although HIV/AIDS-syphilis co-infection status appeared high in heterosexuals, MSM had a moderate level increase in cases. Our results suggested syphilis co-infection in HIV/AIDS cases should be integral part of monitoring in a national sexual transmitted diseases surveillance system. However, our data may provide base for HIV/syphilis prevention and treatment efforts in the future.

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“…The studies and campaigns such as 90-90-90, Fast Track and Undetectable=Untransmittable have led to significant progress in terms of raising public awareness and prevention of the epidemic (7,8). Turkey is one of the countries where the prevalence of HIV is low.…”

Section: Introductionmentioning

confidence: 99%

Stigmatization, discrimination, violation of autonomy and compromised confidentiality: Lived experiences of people living with HIV on the onset of their illness in Turkey

Senyurek

Kavas

Ülman

2020

Preprint

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Background: It’s known that people living with HIV (PLWH) are subjected to stigmatization and discrimination while accessing healthcare services. The purpose of this study is to understand the perceptions of PLWH in Turkey, about whom there are limited data on how their lives are affected by such experiences. Methods: Semi-structured interviews were carried out with 20 people, and the obtained data were analyzed thematically.Results: The results highlighted the following themes: problems with patients’ autonomy, failure to protect patients’ confidentiality and personal health data, spouse/partner notification issues, and stigmatizing and discriminatory attitudes intrinsic to healthcare professionals’ approach. The attitudes of healthcare professionals and health institutions negatively influence the utilization of healthcare services by PLWH. Conclusions: We have argued the necessity to raise the healthcare professionals’ and the society’s knowledge and awareness, and develop national policies that would contribute to structure partner notification services and prevent HIV-related discrimination and stigmata.

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HIV care in Central and Eastern Europe: How close are we to the target?

Cited by 48 publications

References 20 publications

Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study

Stigmatization, discrimination, violation of autonomy and compromised confidentiality: Lived experiences of people living with HIV on the onset of their illness in Turkey

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