HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

Deng, Jing; Mitsuki, Yu-ya; Shen, Guomiao; Ray, Jocelyn C; Cicala, Claudia; Arthos, James; Dustin, Michael L.; Hioe, Catarina E.

doi:10.1128/jvi.01532-16

Cited by 11 publications

(10 citation statements)

References 66 publications

(103 reference statements)

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“…5A,B). These also included synapses hijacked by viral pathogenic factors which resulted in suboptimal signaling and aberrant T-cell-SLB interfaces shaped by the ligation of viral proteins [125][126][127][128][129] (Fig. 5C).…”

Section: The Synapses Of Different Immune Cell Typesmentioning

confidence: 99%

Model membrane systems to reconstitute immune cell signaling

et al. 2020

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Understanding the broad variety of functions encoded in cellular membranes requires experimental systems mimicking both their biochemical composition and biophysical properties. Here, we review the interplay between membrane components and the physical properties of the plasma membrane worth considering for biomimetic studies. Later, we discuss the main advantages and caveats of different model membrane systems. We further expand on how the use of model systems has contributed to the understanding of immune cell signaling, with a specific focus on the immunological synapse. We discuss the similarities of immune synapses observed for innate and adaptive immune cells and focus on the physical principles underlying these similarities.

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Section: The Synapses Of Different Immune Cell Typesmentioning

confidence: 99%

Model membrane systems to reconstitute immune cell signaling

et al. 2020

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“…First, the Nef accessory viral protein, which interferes with endosomal vesicular trafficking and interacts with regulators of actin polymerisation, induces Lck and TCR accumulation in an endosomal compartment, and alters TCR vesicular trafficking, resulting in the decrease of early signalling events (Thoulouze et al, ) Second, the HIV envelope protein gp120, which alters the kinetics of TCR recruitment to the IS and prolongs TCR‐induced activation, leads to increased CD69 upregulation and increased IL‐2 secretion. Thereby, HIV‐1 likely promotes T cell survival to ensure HIV intracellular replication (Deng et al, ).…”

Section: Discussionmentioning

confidence: 99%

Shigellaimpairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and T cell receptor vesicular trafficking

Samassa

Ferrari

Husson

et al. 2020

Cellular Microbiology

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Strategies employed by pathogenic enteric bacteria, such as Shigella, to subvert the host adaptive immunity are not well defined. Impairment of T lymphocyte chemotaxis by blockage of polarised edge formation has been reported upon Shigella infection. However, the functional impact of Shigella on T lymphocytes remains to be determined. Here, we show that Shigella modulates CD4+ T cell F‐actin dynamics and increases cell cortical stiffness. The scanning ability of T lymphocytes when encountering antigen‐presenting cells (APC) is subsequently impaired resulting in decreased cell–cell contacts (or conjugates) between the two cell types, as compared with non‐infected T cells. In addition, the few conjugates established between the invaded T cells and APCs display no polarised delivery and accumulation of the T cell receptor to the contact zone characterising canonical immunological synapses. This is most likely due to the targeting of intracellular vesicular trafficking by the bacterial type III secretion system (T3SS) effectors IpaJ and VirA. The collective impact of these cellular reshapings by Shigella eventually results in T cell activation dampening. Altogether, these results highlight the combined action of T3SS effectors leading to T cell defects upon Shigella infection.

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“…These signaling cascades results in the activation of a series of transcription factors, most notably AP-1, NFAT and NFκB, which lead to the regulation of effector molecules, such as cytokines and chemokines, and the stimulation of cell division. Infectious and virological synapse formation stimulates similar signaling cascades with the important exception that the signaling cascades are antigen-independent (Deng et al, 2016;Hioe et al, 2011;Len et al, 2017;Readinger et al, 2008;Schiralli Lester et al, 2013;Sol-Foulon et al, 2007;Strasner et al, 2008;Vasiliver-Shamis et al, 2009). The strength and outcome of the signaling cascades stimulated during infectious and virological synapse formation on HIV-1 replication is less clear, but recent work by the Jolly laboratory suggests that virological synapses between T cells generate TCR/CD28 signaling cascades in an antigen-independent fashion and that these cascades are important for efficient viral spread (Len et al, 2017).…”

Section: Hiv-1 Cell-to-cell Transmission Involves Cell Signalingmentioning

confidence: 99%

Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir

2019

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HIV-1 spreads through both the release of cell-free particles and by cell-to-cell transmission. Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free transmission of particles and likely influences the pathogenesis of HIV-1 infection. This mode of viral transmission also influences the generation and maintenance of the latent reservoir, which represents the main obstacle for curing the infection. In this review we will discuss general cell contact-dependent mechanisms that HIV-1 utilizes for its spread and the evidence pointing to cellto-cell transmission as a mechanism for the establishment and maintenance of latent infection.

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HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

Cited by 11 publications

References 66 publications

Model membrane systems to reconstitute immune cell signaling

Model membrane systems to reconstitute immune cell signaling

Shigellaimpairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and T cell receptor vesicular trafficking

Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir

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