HIV incidence increasing in MSM in Germany: factors influencing infection dynamics

Marcus, Ulrich; Voss, Lieselotte; Kollan, Christian; Hamouda, Osamah

doi:10.2807/esm.11.09.00645-en

Cited by 53 publications

(44 citation statements)

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“…29 In the same period, in the United Kingdom, Germany, and Italy, a significant increase in the incidence of HIV-1 infection in cohorts of MSM was also observed. [30][31][32] Also in France among the MSM with a new HIV-1 diagnosis the highest proportion of recent infections (46.0%) and an elevated percentage of non-B subtypes (12.0%), after 2003, have been observed. 19 Nevertheless, there are relatively few data on HIV-1 genetic diversity among MSM in Europe, and most of the available data have been provided by national surveillance systems 33,34 or from serosurveys of individuals attending HIV-1 screening programs in urban STI clinics.…”

Section: Discussionmentioning

confidence: 99%

Non-B HIV Type 1 Subtypes among Men Who Have Sex with Men in Rome, Italy

Giuliani

Montieri

Palamara

et al. 2009

AIDS Research and Human Retroviruses

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An increase in the circulation of HIV-1 non-B subtypes has been observed in recent years in Western European countries. Due to the lack of data on the circulation of HIV-1 non-B subtypes among European HIV-1-infected men who have sex with men (MSM), a biomolecular study was conducted in Rome, Italy. HIV-1 partial pol gene sequences from 111 MSM individuals (76 drug naive and 35 drug experienced) were collected during the years [2004][2005][2006]. All these sequences were analyzed using the REGA HIV-1 Subtyping Tool, and aligned using CLUSTAL X followed by manual editing using the Bioedit software. A BLAST search for non-B subtype sequences was also performed. Twenty-six (23.4%) MSM were not Italians. Eight individuals (7.2%) were diag- The CRFs were more prevalent (8.1%) than pure subtypes (5.4%), which were distributed as follows: subtype C (2.6%), subtype A1 (1.7%), and subtype F1 (0.9%). Major mutations conferring resistance to antiretroviral drugs (ARV) were not found among HIV-1 non-B subtype drugnaive patients but were found in two ARV-experienced individuals. The data show that viral diversity is likely increasing in a population group that had been previously characterized by the circulation of HIV-1 subtype B.

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Section: Discussionmentioning

confidence: 99%

Non-B HIV Type 1 Subtypes among Men Who Have Sex with Men in Rome, Italy

Giuliani

Montieri

Palamara

et al. 2009

AIDS Research and Human Retroviruses

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“…It is evident that the differentiation between steady and casual partners leads to different distribution of sexual practice. According to the literature, in some countries the number of sexual partners seems to have increased in recent years [25,26]. This may be a good proxy variable for unsafe sex [9].…”

Section: Discussionmentioning

confidence: 99%

HIV bio-behavioural survey among men who have sex with men in Barcelona, Bratislava, Bucharest, Ljubljana, Prague and Verona, 2008-2009

Mirandola

Folch

Krampac³

et al. 2009

Eurosurveillance

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1R e s e a r c h a r t i c l e s H I V b I o -b e H aV I o u r a l s u r V e y a m o n g m e n w H o H aV e s e x w I t H m e n I n b a r c e l o n a , b r at I s l aVa , b u c H a r e s t , l j u b l j a n a , P r a g u e a n d V e r o n a , 2 0 0 8 -2 0 0 9 Data from 23 European countries show that the annual number of HIV diagnoses in men who have sex with men (MSM) increased by 86% between 2000 and 2006. This paper reports the main preliminary results of a bio-behavioural survey in MSM with a specific focus on HIV prevalence and use of United Nations General Assembly Special Session (UNGASS) indicators in six cities in Southern and Eastern Europe. Time-location sampling (TLS) was used. A total number of 2,356 questionnaires and 2,241 oral fluid samples were collected (invalid samples 4.1%). The data show different socio-demographic patterns across countries regarding age, level of education, living conditions, living area and selfidentity. Southern European cities had the highest percentage of people who had tested for HIV and collected the result. More than 50% of respondents in the sample from Barcelona reported having used a condom last time they had anal sex (57.2%), whilst in all other cities this proportion was below 50%. The cities with the highest HIV prevalence in MSM were Barcelona (17.0%) and Verona (11.8%) whilst lower percentages were reported in Bratislava (6.1%), Bucharest (4.6%), Ljubljana (5.1%) and Prague (2.6%). The low prevalence in Eastern European cities is encouraging. However, with the level of high-risk sexual behaviour documented and the lower frequency of HIV test seeking behaviour, there is a clear risk of an increase in HIV transmission.

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“…13,14 Second, 'seropositioning', where HIV-negative MSM adopt the insertive role in UAI to reduce their HIV risk, is being commonly reported throughout the world. 5,15 Should increasing proportions of uncircumcised HIV-negative MSM take the insertive role in UAI with HIV-positive partners, then the proportion of new HIV infections attributable to insertive UAI is likely to increase.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] Much research in recent years has focussed on potential biomedical interventions to prevent HIV transmission. Strategies, including candidate microbicides and vaccines, have thus far failed to provide protection against HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Minimal impact of circumcision on HIV acquisition in men who have sex with men

et al. 2010

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Abstract. Background:Men who have sex with men (MSM) are disproportionately affected by HIV. The proven efficacy of circumcision in reducing the risk of HIV acquisition among African heterosexual males has raised the question of whether this protective effect may extend to MSM populations. We examined the potential impact of circumcision on an HIV epidemic within a population of MSM. Methods: A mathematical model was developed to simulate HIV transmission in an MSM population. The model incorporated both circumcision and seropositioning, and was used to predict the reduction in HIV prevalence and incidence as a result of the two interventions. Estimates for the time required to achieve these gains were also calculated. Results: We derive simple formulae for the decrease in HIV prevalence with increased circumcision. Our model predicts that if an initially uncircumcised MSM population in a developed country with a baseline HIV prevalence of 10% underwent universal circumcision, HIV incidence would only be reduced to 95% of preintervention levels and HIV prevalence to 9.6% after 20 years. In the longer term, our model predicts that prevalence would only decrease from 10% to 6%, but this would take several generations to achieve. The effectiveness of circumcision increases marginally with higher degrees of seropositioning. Conclusions: The results of these calculations suggest that circumcision as a public health intervention will not produce a substantial decrease in HIV prevalence or incidence among MSM in the near future, and only modest reductions are achievable in the long-term.

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HIV incidence increasing in MSM in Germany: factors influencing infection dynamics

Cited by 53 publications

References 0 publications

Non-B HIV Type 1 Subtypes among Men Who Have Sex with Men in Rome, Italy

Non-B HIV Type 1 Subtypes among Men Who Have Sex with Men in Rome, Italy

HIV bio-behavioural survey among men who have sex with men in Barcelona, Bratislava, Bucharest, Ljubljana, Prague and Verona, 2008-2009

Minimal impact of circumcision on HIV acquisition in men who have sex with men

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