HIV-induced immune deficiency is associated with a higher risk of hepatocarcinoma, ANRS CO3 Aquitaine Cohort, France, 1998–2008

Bruyand, Mathias; Dabis, François; Vandenhende, Marie-Anne; Lazaro, Estibaliz; Néau, Didier; Leleux, Olivier; Geffard, S.; Morlat, Philippe; Chêne, Geneviève; Bonnet, Fabrice

doi:10.1016/j.jhep.2011.02.017

Cited by 19 publications

(17 citation statements)

References 17 publications

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“…In HIV/ HCV-co-infected patients, an independent association has been reported between CD4 cell depletion and HCC onset [34][35][36]. However, some of these studies only examined the absolute CD4 cell count and not the CD4 cell percentage [34,36], while it is well established that extensive fibrosis is associated with low absolute CD4 cell counts in the absence of HIV infection [37]. In our study, which included only cirrhotic patients, no associations were found between the occurrence of HCC and the CD4 cell nadir, the CD4 cell count (absolute or percentage), the duration of HIV infection, the CDC class of HIV disease or a lack of HIV suppression.…”

Section: Discussionmentioning

confidence: 97%

“…In keeping with previous reports, we found that older age was associated with a higher risk of HCC. In HIV/ HCV-co-infected patients, an independent association has been reported between CD4 cell depletion and HCC onset [34][35][36]. However, some of these studies only examined the absolute CD4 cell count and not the CD4 cell percentage [34,36], while it is well established that extensive fibrosis is associated with low absolute CD4 cell counts in the absence of HIV infection [37].…”

Section: Discussionmentioning

confidence: 99%

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Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH

Salmon

Bani‐Sadr

Loko

et al. 2012

Journal of Hepatology

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH

Salmon

Bani‐Sadr

Loko

et al. 2012

Journal of Hepatology

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“…9;10 These studies only had 26 and 16 cases of HCC, respectively, and were not restricted to those with HCV coinfection. In addition, Ioannou et al examined all veterans with HIV and did not limit to those at the highest risk for HCC.…”

Section: Discussionmentioning

confidence: 99%

“…9 While another small study conducted in France in only 16 HIV-infected cases with HCC (3 with HBV and 11 with HCV) demonstrated that current CD4+ <350 was independently associated with increased risk for HCC. 10 Finally, Ioannou et al examined the prevalence of cirrhosis and HCC in US veterans with HIV and reported that a detectable HIV viral load at the time of HCC diagnosis was not associated with HCC risk, while low CD4+ count was associated with an increased risk for HCC (AOR=2.36; 95%CI: 1.3–4.2). 11 This study was not limited to veterans with HCV coinfection and only examined HIV viral loads and CD4+ counts in a two year period.…”

Section: Introductionmentioning

confidence: 99%

The Effect of HIV Viral Control on the Incidence of Hepatocellular Carcinoma in Veterans With Hepatitis C and HIV Coinfection

Kramer

Kowalkowski

Duan

et al. 2015

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background HIV increases the risk of progression to hepatic fibrosis and cirrhosis among individuals coinfected with hepatitis C virus (HCV). However, the impact of HIV-related immune suppression on the risk of hepatocellular carcinoma (HCC) is currently unknown. Methods We used the VA HIV Clinical Case Registry to identify patients with HIV infection between 1985 and 2010 and HCV coinfection (positive HCV RNA or genotype test) between 1995 and 2010. The outcome was incident HCC as indicated by ICD-9 code (87% positive predictive value). Patients with HCV monoinfection were included as a comparison group for HCC incidence. Age-adjusted HCC incidence rates were calculated for the coinfected cohort and HCV monoinfected cohort. Cox proportional hazards models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to HCC diagnosis in the coinfected cohort. Results There were 66,991 veterans with HIV; 8,563 had at least one positive HCV RNA test, and 234 of these developed HCC. The overall age-adjusted incidence rate of HCC in monoinfected patients was 2.99/1000 PY vs. 4.44/1000 PY in coinfected patients. In patients with coinfection, presence of cirrhosis (HR=4.88; 95%CI: 3.30–7.21), HIV diagnosis >2002 (HR=4.65; 95%CI: 2.70–8.02), and a recent low CD4+ cell count <200 (HR=1.71; 95%CI: 1.20–2.45) were associated with an increased risk for HCC. Conclusions The risk of HCC in HCV-HIV coinfected veteran men was higher than HCV monoinfection. Diagnosis of cirrhosis and low recent CD4+ cell count were the most important predictors of developing HCC in this group.

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“…In studies performed in the pre-cART era, co-infection of HIV and HCV increased the risk of liver fibrosis and cirrhosis 196 , while cART decreased progression to cirrhosis in HIV/HCV co-infected patients 197 . Decreased CD4 + T-cell count (< 200–500 cells/mm 3 ) has been associated with risk for HCC in several small studies 198,199 , and confirmed in a large retrospective study involving 8,563 veterans co-infected with HIV and HCV. The risk of HCC in co-infected patients was increased compared to patients infected with HCV only.…”

Section: Cancer Prevention Interventionsmentioning

confidence: 77%

Cancer prevention in HIV-infected populations

Gonçalves

Montezuma-Rusca

Yarchoan

et al. 2016

Seminars in Oncology

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People living with human immunodeficiency virus (HIV) are living longer since the advent of effective combined antiretroviral therapy (cART). While cART substantially decreases the risk of developing some cancers, HIV-infected individuals remain at high risk for Kaposi sarcoma, lymphoma and several solid tumors. Currently HIV-infected patients represent an aging group, and malignancies have become a leading cause of morbidity and mortality. Tailored cancer-prevention strategies are needed for this population. In this review we describe the etiologic agents and pathogenesis of common malignancies in the setting of HIV, as well as current evidence for cancer prevention strategies and screening programs.

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HIV-induced immune deficiency is associated with a higher risk of hepatocarcinoma, ANRS CO3 Aquitaine Cohort, France, 1998–2008

Cited by 19 publications

References 17 publications

Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH

Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH

The Effect of HIV Viral Control on the Incidence of Hepatocellular Carcinoma in Veterans With Hepatitis C and HIV Coinfection

Cancer prevention in HIV-infected populations

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