HIV infection and isolated detection of anti-HBc

Vazquez-Vizoso, Francisco; Eiroa, Peregrina; Ledo, L.; Anibarro, Luis; Hernández, M.; Ojea, Rafael

doi:10.1016/0016-5085(94)90735-8

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…Similar to our findings, two studies also found that lower CD4 counts (<400 or <500 cells/μL) were associated with presence of isolated anti‐HBc in HIV‐positive patients [24,25]. Patients in most of the other studies had higher CD4 counts (median CD4 counts of 300–459 cells/μL or 62–76% of study population with CD4 counts >200 cells/μL) (Table 3), while our patients had a median CD4 count of 264 cells/μL, and 58.7% of them had CD4 counts >200 cells/μL.…”

Section: Discussionsupporting

confidence: 89%

“…For example, four studies comparing patients with isolated anti‐HBc with those negative for all three markers identified HCV infection, male, older age and injecting drug use as the main risk factors [5–7,20], while in another three studies that selected patients without isolated anti‐HBc as the reference group, HCV infection was reported to be the risk factor in two studies, injecting drug use in one study and low CD4 counts in another study [4,9,11]. In another six studies, patients with isolated anti‐HBc were compared with patients positive for both anti‐HBs and anti‐HBc, and HCV infection was the risk factor in three studies, low CD4 counts (<400 cells/μL in one study and <100 cells/μL in the present study) in two, injecting drug use in one, and HCV genotype 4c/4d in one [8,21–24].…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with isolated anti‐hepatitis B core antibody in HIV‐positive patients: impact of compromised immunity

Sun

Lee

Liu

et al. 2010

Journal of Viral Hepatitis

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In regions that are hyperendemic for chronic hepatitis B virus (HBV) infection, prevalence of and risk factors associated with isolated anti-hepatitis B core antibody (anti-HBc) in HIV-positive patients are less well described. HIV-positive patients who were tested for hepatitis B surface antigen (HBsAg), anti-hepatitis B surface antibody (anti-HBs) and anti-HBc at designated hospitals for HIV care in Taiwan were included for analysis. HBV DNA was detected by real-time polymerase chain reaction in patients with and without isolated anti-HBc. Of 2351 HIV-positive patients, 450 (19.1%) were HBsAg positive, 411 (17.5%) were anti-HBc positive alone and 963 (41.0%) for both anti-HBs and anti-HBc. Compared with patients who were positive for both anti-HBs and anti-HBc, patients with isolated anti-HBc were older, less likely to have anti-hepatitis C virus antibody (anti-HCV), had lower CD4 lymphocyte counts and higher plasma HIV RNA loads. Older age (adjusted odds ratio, 1.029; 95% confidence interval, 1.015-1.043) and CD4 <100 cells/microL (adjusted odds ratio, 1.524; 95% confidence interval, 1.025-2.265) were independently associated with isolated anti-HBc by logistic regression, while presence of anti-HCV and injecting drug use were not. HBV DNA was detectable in 8.3% of 277 patients with isolated anti-HBc and 14.3% of 56 patients with both anti-HBs and anti-HBc (P = 0.160). In a country hyperendemic for HBV infection, HIV-positive patients at older age and with CD4 <100 cells/microL were more likely to have isolated anti-HBc, suggesting that compromised immunity plays a role in the presence of this marker.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Factors associated with isolated anti‐hepatitis B core antibody in HIV‐positive patients: impact of compromised immunity

Sun

Lee

Liu

et al. 2010

Journal of Viral Hepatitis

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“…Older age and CD4 counts were independently associated with presence of isolated anti-HBc. Similar to these findings; two studies also found that decreased CD4 values were linked with presence of anti-HBc in patients on ART [7].…”

Section: Discussionsupporting

confidence: 73%

Prevalence of Anti-HBc in HIV Patients on ART in Ekiti, Nigeria

Opaleye

Adetona

Sunday

et al. 2015

IJTDH

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Background: In HIV -infected individuals, anti-HBc which is an indicator of occult hepatitis B is a common phenomenon Aim: The aim of this study is to determine the sero-epidemiology and associated risk factors among HIV-infected individuals in Ikole Ekiti, Nigeria. Study Population and Duration: HIV/AIDS individuals visiting Institute of Human Virology of Nigeria, Specialist Clinic, Ikole Ekiti between November 2012 and April 2013 were included in this study. Methodology: One hundred and eighty eight HIV samples were tested for anti-Hepatitis B core antibody by Enzyme Linked Immunosorbent Assay (ELISA) {ANTICORASE MB-96 [TMB] from General Biological Corporation}. Data were analysed using software within SPSS packages. Results: Twenty two (11.7%) of 188 HIV-infected patients had isolated anti-HBc. Co-infection of HIV-HBV in males (3.23%) differed significantly from that of females (8.51%). Highest coinfection Case Study

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“…This finding is remarkable, considering that 130% of the subjects who were examined were HIV-positive, a condition associated with immunity dysfunction, and, therefore, these subjects were at risk for reactivation or reinfection with HBV [8,9].…”

mentioning

confidence: 83%

Isolated Presence of Antibody to Hepatitis B Core Antigen in Injection Drug Users: Do They Need to Be Vaccinated?

Quaglio

Lugoboni

Vento

et al. 2001

Clinical Infectious Diseases

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In a study of 497 injection drug users who had isolated presence of antibody to hepatitis B core antigen (anti-HBc) at the time of enrollment, 404 (81%) retained this condition after a mean of 49 months of follow-up, during which time no new hepatitis B surface antigen marker was detected. These findings support the hypothesis that patients with isolated presence of anti-HBc have strong resistance to reinfection and do not need vaccination.

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HIV infection and isolated detection of anti-HBc

Cited by 13 publications

References 3 publications

Factors associated with isolated anti‐hepatitis B core antibody in HIV‐positive patients: impact of compromised immunity

Factors associated with isolated anti‐hepatitis B core antibody in HIV‐positive patients: impact of compromised immunity

Prevalence of Anti-HBc in HIV Patients on ART in Ekiti, Nigeria

Isolated Presence of Antibody to Hepatitis B Core Antigen in Injection Drug Users: Do They Need to Be Vaccinated?

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