HIV infection increases the risk of squamous intra-epithelial lesions in women with HPV infection: An analysis of HPV genotypes

Cappiello, Giuseppina; Garbuglia, Anna Rosa; Salvi, Roberto; Rezza, Giovanni; Giuliani, Massimo; Pezzotti, Patrizio; Suligoi, Barbara; Branca, Margherita; Migliore, G; Pomponi, Donatella Formigoni; D'Ubaldo, C.; Ippolito, Giuseppe; Giacomini, G; Benedetto, A.

doi:10.1002/(sici)1097-0215(19970917)72:6<982::aid-ijc11>3.0.co;2-7

Cited by 34 publications

(5 citation statements)

References 22 publications

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“…Even though other studies (24,25) show higher changes of previous or concomitant STD in women with HIV, this analysis identified a high rate of STD in the control group, probably due to the low use of condoms and multiple sexual partners in the past year.…”

Section: Discussioncontrasting

confidence: 80%

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Conradesque

Dagostin

Fedrizzi

et al. 2023

J Bras Doenças Sex Transm

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Introduction: The human papillomavirus (HPV) is the most common sexually transmitted infection among women. The HPV of high oncogenic risk, associated with other factors, presents a risk of progressing to a precancerous lesion of the uterus and even cancer. Such an evolution is related to the persistence of the infection and other factors, mainly those that interfere with women’s immunity. The immunosuppression caused by HIV infection is an important factor for viral persistence and the onset of these lesions. Objectives: To compare the prevalence of HPV infection and cervical intraepithelial lesions in HIV-positive and negative women and describe the possible associated risk factors. Methods: The sample consisted of 50 HIV positive women (study group) and 50 HIV negative women (control group) recruited from the public health system of Florianópolis from January to April 2022. Cervical samples were collected for cytological analysis and for the detection of high-risk oncogenic HPV DNA by polymerase chain reaction (PCR). Categorical variables were compared using the chi-square test, with a significance level set at 5% Results: HPV infection was more prevalent in the control group; however, HIV positive women presented higher frequency of intraepithelial lesions diagnosed on cytology. Factors such as higher number of sexual partners, depression and smoking were more frequent in the group of HIV positive women. CD4 T cells lower than 200 cells/mm3 was associated with a higher number of altered Pap smears and a positive HPV DNA test. The use of combination antiretroviral therapy and undetectable viral load were associated with more frequent normal cytology and undetected HPV DNA. Conclusion: The prevalence of cervical intraepithelial lesions in HIV-infected women is higher than among women without the infection. The presence of HIV infection was the most important risk factor associated with the development of cervical lesions.

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Section: Discussioncontrasting

confidence: 80%

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Conradesque

Dagostin

Fedrizzi

et al. 2023

J Bras Doenças Sex Transm

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“…Alternatively, it could be due to misclassification of the Pap smear. Another five women with cytological evidence of CIN were reactive for the low risk probe only, a finding that is quite unusual in immunocompetent women, though it has been described in HIV-infected patients [6].…”

Section: Discussionmentioning

confidence: 85%

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

Levi¹,

Mc²,

Cl³

et al. 2002

Braz J Infect Dis

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HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD 4 + cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD 4 /µL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.

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“…Several previous studies have shown varying risk of ICC in association with HIV infection [12,35-41]. Earlier studies suggested that a possible increase in cervical cancer risk among HIV-positive women could be attributed to the increased prevalence of HPV infection, or persistence of HPV infection [42,43].…”

Section: Discussionmentioning

confidence: 99%

HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

Odida

Sandin

Mirembe

et al. 2011

Infect Agents Cancer

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BackgroundWhile the association of human papillomavirus (HPV) with cervical cancer is well established, the influence of HIV on the risk of this disease in sub-Saharan Africa remains unclear. To assess the risk of invasive cervical carcinoma (ICC) associated with HIV and HPV types, a hospital-based case-control study was performed between September 2004 and December 2006 in Kampala, Uganda. Incident cases of histologically-confirmed ICC (N=316) and control women (N=314), who were visitors or care-takers of ICC cases in the hospital, were recruited. Blood samples were obtained for HIV serology and CD4 count, as well as cervical samples for HPV testing. HPV DNA detection and genotyping was performed using the SPF10/DEIA/LiPA25 technique which detects all mucosal HPV types by DEIA and identifies 25 HPV genotypes by LiPA version 1. Samples that tested positive but could not be genotyped were designated HPVX. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for possible confounding factors. ResultsFor both squamous cell carcinoma (SCC) and adenocarcinoma of the cervix, statistically significantly increased ORs were found among women infected with HPV, in particular single HPV infections, infections with HPV16-related types and high-risk HPV types, in particular HPV16, 18 and 45. For other HPV types the ORs for both SCC and adenocarcinoma were not statistically significantly elevated. HIV infection and CD4 count were not associated with SCC or adenocarcinoma risk in our study population. Among women infected with high-risk HPV types, no association between HIV and SCC emerged. However, an inverse association with adenocarcinoma was observed, while decrease in CD4 count was not associated with ICC risk.ConclusionsThe ORs for SCC and adenocarcinoma were increased in women infected with HPV, in particular single HPV infections, infections with HPV16- and 18-related types, and high-risk HPV types, specifically HPV16, 18 and 45. HIV infection and CD4 count were not associated with SCC or adenocarcinoma risk, but among women infected with high-risk HPV types there was an inverse association between HIV infection and adenocarcinoma risk. These results suggest that HIV and CD4 count may have no role in the progression of cervical cancer.

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HIV infection increases the risk of squamous intra-epithelial lesions in women with HPV infection: An analysis of HPV genotypes

Cited by 34 publications

References 22 publications

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Prevalence of HPV infection and cervical intraepithelial lesions in HIV positive and negative women in the city of Florianopolis

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

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