Hiv Infection of Rectal Mucosa

Mathijs, Jean-Marie; Hing, Michael; Grierson, J. M.; Dwyer, Dominic E.; Goldschmidt, Carolyn; Cooper, DA; Cunningham, Anthony L.

doi:10.1016/s0140-6736(88)91932-0

Cited by 75 publications

(26 citation statements)

References 3 publications

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“…In this regard, herpes simplex virus and syphilis infections in the United States have also correlated with an increased risk of HIV transmission among heterosexuals (484). Nevertheless, subsequent studies of biopsy tissues have shown that the bowel mucosa and perhaps the cervical epithelium can be directly infected by HIV (453,679,744,843,937) without the need for ulcerations.…”

Section: Transmission By Blood and Blood Productsmentioning

confidence: 99%

“…The presence of HIV in mucosal cells in the bowel has been detected by cell culture, in situ hybridization, and PCR studies of all regions of the gastrointestinal tract (371,453,600,744,843). The cell types considered infected include goblet and columnar epithelial cells and enterochromaffin cells (454,679,843).…”

Section: Cells and Tissues Infected By Hivmentioning

confidence: 99%

“…Recent studies have now demonstrated the presence of HIV itself in the bowel mucosa of patients with gastrointestinal disorders as well as in asymptomatic individuals (453,600,744,843). In several cases, it is the only pathogen found in the bowel.…”

Section: Hiv-associated Bowel Disordersmentioning

confidence: 99%

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Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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Section: Transmission By Blood and Blood Productsmentioning

confidence: 99%

Section: Cells and Tissues Infected By Hivmentioning

confidence: 99%

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Pathogenesis of Human Immunodeficiency Virus Infection

Levy¹

1989

Annals of the New York Academy of Sciences

222

290

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“…This transmission occurs predominantly across genital or rectal mucosa during heterosexual or homosexual contacts, which currently account for up to 80% of the global prevalence of HIV/AIDS (Miller, McGhee, & Gardner, 1993;Phillips et al, 1994). Infectious HIV can be isolated from the rectal mucosa of seropositive individuals (Mathijs et al, 1988;Nelson et al, 1988) and HIV antigens have also been found in cells of cervical biopsy specimens from HIV-infected women (Pomerantz et al, 1988). These studies provide evidence that mucosal cells harbor HIV during the course of AIDS.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Enhancing efficacy and mucosa-tropic distribution of an oral HIV-PsV DNA vaccine in animal models

Fu¹,

Bian²,

Zhao³

et al. 2009

Journal of Drug Targeting

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“…Importantly, infectious HIV can be isolated from the rectal mucosae of seropositive individuals (44,51). HIV antigens have also been found in cells of cervical biopsy specimens from HIV-infected women (57).…”

mentioning

confidence: 99%

Human Immunodeficiency Virus Type 1 Gag-Specific Mucosal Immunity after Oral Immunization with Papillomavirus Pseudoviruses Encoding Gag

Zhang

Fayad

Wang

et al. 2004

J Virol

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Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV) transmission. Because systemic immunization, in general, does not induce effective mucosal immune responses, a mucosal HIV vaccine is urgently needed. For this study, we developed papillomavirus pseudoviruses that express HIV-1 Gag. The pseudoviruses are synthetic, nonreplicating viruses, yet they can produce antigens for a long time in the immune system. Here we show that oral immunization of mice by the use of papillomavirus pseudoviruses encoding Gag generated mucosal and systemic Gag-specific cytotoxic T lymphocytes that effectively lysed Gag-expressing target cells. Furthermore, the pseudoviruses generated Gag-specific gamma interferon-producing T cells and serum immunoglobulin G (IgG) and mucosal IgA. In contrast, oral immunization with plasmid DNA encoding HIV-1 Gag did not induce specific immune responses. Importantly, oral immunization with the pseudoviruses induced Gag-specific memory cytotoxic T lymphocytes and protected mice against a rectal mucosal challenge with a recombinant vaccinia virus expressing HIV-1 Gag. Thus, papillomavirus pseudoviruses encoding Gag are a promising mucosal vaccine against AIDS.

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Hiv Infection of Rectal Mucosa

Cited by 75 publications

References 3 publications

Pathogenesis of Human Immunodeficiency Virus Infection

Pathogenesis of Human Immunodeficiency Virus Infection

WITHDRAWN: Enhancing efficacy and mucosa-tropic distribution of an oral HIV-PsV DNA vaccine in animal models

Human Immunodeficiency Virus Type 1 Gag-Specific Mucosal Immunity after Oral Immunization with Papillomavirus Pseudoviruses Encoding Gag

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