HIV Life Cycle: Targets for Anti‐HIV Agents

Clercq, Erik De

doi:10.1002/9781118015377.ch1

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…The HIV replication process that takes place in CD4 cells can be broken down into seven steps: (1) HIV binding to CD4 cell receptors; (2) membrane fusion, allowing HIV entry into the CD4 cell; (3) reverse transcription, converting HIV RNA to DNA; (4) integration of HIV DNA with CD4 cell DNA; (5) replication of the necessary protein chains; (6) assembly of new HIV proteins and RNA; and (7) budding, wherein HIV exits the CD4 cell and matures to eventually repeat this process with another CD4 cell. Importantly, primary HIV infection does not occur until the fourth step, integration, after an incubation period of 12 to 72 h from initial exposure [22,23].…”

Section: Overview Of Prep For Substance Use Counselorsmentioning

confidence: 99%

Responding to the HIV Health Literacy Needs of Clients in Substance Use Treatment: The Role of Universal PrEP Education in HIV Health and Prevention

Zhai,

Isadore,

Parker

et al. 2023

IJERPH

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Health literacy, particularly HIV health literacy, is a key social determinant of health and can be significantly improved through targeted health education. This paper explores the often-overlooked potential of pre-exposure prophylaxis (PrEP) education as a powerful tool to enhance HIV health literacy among people with substance use disorders (PWSUD), a population notably susceptible to HIV. Given the syndemic interplay of substance use disorders (SUDs) and HIV, health professionals, especially substance use counselors, are uniquely positioned to bolster HIV health literacy and positively influence health outcomes. This article offers a brief introduction to PrEP, delineates potential barriers and facilitators to its use and education, and proposes strategies for effective PrEP education, implementation, and adherence. By equipping substance use counselors with essential knowledge and skills, we aim to encourage and promote the integration of PrEP education into substance use treatment. The overarching objective is to empower counselors to proactively engage in HIV prevention efforts, thereby fulfilling pressing health literacy needs and contributing to improved health outcomes among PWSUD.

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Section: Overview Of Prep For Substance Use Counselorsmentioning

confidence: 99%

Responding to the HIV Health Literacy Needs of Clients in Substance Use Treatment: The Role of Universal PrEP Education in HIV Health and Prevention

Zhai,

Isadore,

Parker

et al. 2023

IJERPH

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“…In recent years, our understanding of the HIV-host interaction has dramatically increased, opening the possibility for the discovery of novel classes of therapeutics [ 8 , 12 – 14 ]. Not surprisingly, there are numerous interactions between HIV and cellular proteins involved in all stages of virus replication [ 8 ].…”

Section: Introduction: Cofactors Of Integration As Potential Antivmentioning

confidence: 99%

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

Taltynov

Desimmie

Demeulemeester

et al. 2012

Molecular Biology International

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To accomplish their life cycle, lentiviruses make use of host proteins, the so-called cellular cofactors. Interactions between host cell and viral proteins during early stages of lentiviral infection provide attractive new antiviral targets. The insertion of lentiviral cDNA in a host cell chromosome is a step of no return in the replication cycle, after which the host cell becomes a permanent carrier of the viral genome and a producer of lentiviral progeny. Integration is carried out by integrase (IN), an enzyme playing also an important role during nuclear import. Plenty of cellular cofactors of HIV-1 IN have been proposed. To date, the lens epithelium-derived growth factor (LEDGF/p75) is the best studied cofactor of HIV-1 IN. Moreover, small molecules that block the LEDGF/p75-IN interaction have recently been developed for the treatment of HIV infection. The nuclear import factor transportin-SR2 (TRN-SR2) has been proposed as another interactor of HIV IN-mediating nuclear import of the virus. Using both proteins as examples, we will describe approaches to be taken to identify and validate novel cofactors as new antiviral targets. Finally, we will highlight recent advances in the design and the development of small-molecule inhibitors binding to the LEDGF/p75-binding pocket in IN (LEDGINs).

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HIV Life Cycle: Targets for Anti‐HIV Agents

Cited by 2 publications

References 40 publications

Responding to the HIV Health Literacy Needs of Clients in Substance Use Treatment: The Role of Universal PrEP Education in HIV Health and Prevention

Responding to the HIV Health Literacy Needs of Clients in Substance Use Treatment: The Role of Universal PrEP Education in HIV Health and Prevention

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

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