HIV‐negative disseminated Kaposi's sarcoma in a Taiwanese patient

Huang, Chiung-Tang; Chang, Chih‐Hau; Maa, Hung-Chune; Cho, Shih‐Feng; Liu, Ta-Chih

doi:10.1016/j.kjms.2011.06.025

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Previously, Huang et al . described a case of hepatitis B carrier that developed HIV‐negative disseminated KS . In addition, other studies considered diabetes as an important predisposing factor for KS development .…”

Section: Discussioncontrasting

confidence: 70%

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

et al. 2019

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Background Most of the previous reports regarding the clinical features of Kaposi's sarcoma (KS) have been performed in Western and African countries. The clinical characteristics of KS have not been well defined in Han Chinese or Taiwanese patients. In this study, we analyzed the clinical features of KS patients in a Taiwanese medical center. Methods Medical records from Kaohsiung Medical University Hospital over the past 20 years (1996–2016) were comprehensively reviewed. Results There were 55 patients with KS (50 males and 5 females), including 37 patients (67%) with classic disease, 17 patients (31%) with AIDS‐associated disease, and one patient (2%) with immunosuppressive medication‐related disease. The average age was 58.7 years (range 20–87 years), and the average age was younger for AIDS patients (33.8 years) compared with non‐AIDS patients (69.8 years). Among patients with classic KS, lesions were mostly localized to the lower extremities, whereas AIDS‐associated KS patients were more likely to develop disseminated skin lesions, skin lesions on atypical sites (head and neck, trunk), and extracutaneous involvement (particularly oral cavity). The most common underlying diseases were diabetes mellitus (20% of patients) and hepatitis B (15% patients), and 38% of KS patients were smokers. Patients with AIDS‐associated KS usually responded well to chemotherapy, whereas only 32% of patients with non‐AIDS‐associated KS showed complete response to radiotherapy. Conclusions The findings of the current study will serve as important references for clinicians in the diagnosis of KS and may form the basis for the implementation of KS clinical practice guidelines in Taiwan.

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Section: Discussioncontrasting

confidence: 70%

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

et al. 2019

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“…People in the Han Chinese ethnic group populate 84% of Taiwan [9]. Therefore, it is not surprising that classic KS is extremely rare in Taiwan, with very few reports describing the manifestations of disease in this population [6,10].…”

Section: Introductionmentioning

confidence: 99%

Classic Kaposi sarcoma in an HIV-negative Han Chinese man: a case report

Mitre

Applebaum²,

Potenziani³

et al. 2017

Dermatology Online Journal

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From Chemistry to Translational Medicine: The Application of Proteomics to Cancer Biomarker Discovery and Diagnosis

Chiou

Huang

Liang

2015

J Chinese Chemical Soc

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The study of complex protein mixtures and their interactions in cells and tissues has been difficult due to the tedious process involved in their characterization and analysis. The recent emergence of fast-evolving and state-of-the-art proteomics methodologies has provided a rapid and scalable platform for understanding the comprehensive proteome profiles from complex whole tissues or cells of various biological sources. Therefore, proteomics has been increasingly valuable to examine real-time changes in protein expression of various tissues or body fluids from patients with various diseases, especially cancer, resulting in the identification of clinically useful biomarkers for diagnosis, prognosis and disease staging. In this review, we focus on potential biomarkers for (1) Helicobacter pylori-associated gastric cancer, (2) hepatocellular carcinoma (HCC), and (3) renal cell carcinoma (RCC). In addition to the conventional gel-based proteomics (1-D or 2-D gels), we have utilized a more advanced proteomic approach by incorporating stable isotope dimethyl labelling and shotgun proteomics strategy in combination with nano-liquid chromatography and tandem mass spectrometry (nanoLC-MS/MS) to better characterize the biomarkers in several cancer tissues. By establishing a high-throughput proteomics platform based on multiple reaction monitoring (MRM), we have successfully detected and analyzed potential protein markers at low concentrations in various normal and tumor tissues. This platform not only highlights the utility of proteomics for biomarker discovery but also can be uniquely applied to disease-oriented translational medicine for diagnosis of diverse types of cancers and other diseases.

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HIV‐negative disseminated Kaposi's sarcoma in a Taiwanese patient

Cited by 6 publications

References 8 publications

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

Classic Kaposi sarcoma in an HIV-negative Han Chinese man: a case report

From Chemistry to Translational Medicine: The Application of Proteomics to Cancer Biomarker Discovery and Diagnosis

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