HIV Patient with Mucous Membrane Pemphigoid: A Case Report

Singh, Annette; Chaitra, T R; Ravishankar, TL; Singh, Surendra; Mohapatra, Ashok K.

doi:10.4314/ejhs.v24i2.12

Cited by 6 publications

(7 citation statements)

References 10 publications

(19 reference statements)

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“…Mucous membrane pemphigoid (MMP) has been known by different names including benign mucous membrane pemphigoid, cicatricial (scarring) pemphigoid, and ocular cicatricial pemphigoid [ 61 ]. MMP is a common immune-mediated subepithelial blistering disease mainly affecting oral mucosa (over 90%); however, skin lesions are also present in 20% to 30% of cases.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Mortazavi

Safi

Baharvand

et al. 2016

International Journal of Dentistry

145

132

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Diagnosis of oral ulcerative lesions might be quite challenging. This narrative review article aims to introduce an updated decision tree for diagnosing oral ulcerative lesions on the basis of their diagnostic features. Various general search engines and specialized databases including PubMed, PubMed Central, Medline Plus, EBSCO, Science Direct, Scopus, Embase, and authenticated textbooks were used to find relevant topics by means of MeSH keywords such as “oral ulcer,” “stomatitis,” and “mouth diseases.” Thereafter, English-language articles published since 1983 to 2015 in both medical and dental journals including reviews, meta-analyses, original papers, and case reports were appraised. Upon compilation of the relevant data, oral ulcerative lesions were categorized into three major groups: acute, chronic, and recurrent ulcers and into five subgroups: solitary acute, multiple acute, solitary chronic, multiple chronic, and solitary/multiple recurrent, based on the number and duration of lesions. In total, 29 entities were organized in the form of a decision tree in order to help clinicians establish a logical diagnosis by stepwise progression.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Mortazavi

Safi

Baharvand

et al. 2016

International Journal of Dentistry

145

132

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“…In the three published case reports of mucous membrane pemphigoid (MMP) or cicatricial pemphigoid in patients with HIV, CD4 counts were normal or near normal ( Table 4 ; Demathe et al, 2008 , Lish et al, 1997 , Singh et al, 2014 ). Patients were successfully treated with dapsone and topical or intralesional corticosteroids.…”

Section: Autoimmune Blistering Disorders In Hiv/aidsmentioning

confidence: 99%

“…Autoimmune blistering disorders (AIBDs) comprise a heterogeneous group of diseases that are characterized by autoantibodies directed against adhesion proteins in the skin and mucous membranes. Cases of AIBD in patients with HIV have also been increasingly reported, and in some instances the initial clinical presentation of AIBD compels a workup that reveals a previously unknown positive HIV status ( Chou et al, 1991 , Lateef et al, 1999 , Marfatia et al, 2007 , Singh et al, 2014 ). Interestingly, pemphigus vulgaris and bullous pemphigoid-like antibodies have been reported as detectable in the blood of up to 33% of patients with AIDS.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of AIBDs in patients with HIV is complicated by potential further immunosuppression in an already dysfunctional immune system by initiation of long-term systemic immunosuppressants. The possible hastening of opportunistic infections and AIDS-defining illnesses are major risks to weigh against the benefits of treatment ( Singh et al, 2014 ). Therefore, treatment options for AIBD in HIV-positive patients pose a unique clinical challenge.…”

Section: Introductionmentioning

confidence: 99%

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Autoimmune blistering disorders in the setting of human immunodeficiency virus infection

Min

Damstetter²,

Chen

2018

International Journal of Women's Dermatology

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The interplay between immune dysfunction and human immunodeficiency virus (HIV) is complex. Reports of autoimmune disorders including autoimmune bullous disorders (AIBDs) have been increasing in prevalence in the HIV population since the introduction of highly active antiretroviral therapy in 1995. We offer a literature review of clinical experiences in various AIBDs with particular emphasis on therapeutic management as well as a brief overview of the mechanisms that explain the relationship between AIBD and HIV. Because immunosuppressants are first-line therapies for AIBD treatment, careful consideration is warranted when considering management in the HIV population.

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“…The etiopathogenesis is still unknown; however, it is thought that environmental factors combined with genetic susceptibility lead to CP. There have been some reported cases of CP triggered by human immunodeficiency virus, diphtheria vaccination, and some medications such as methyldopa, clonidine, and D-penicillamine [110,111]. In addition, other autoimmune diseases may occur more frequently in patients with CP [112].…”

Section: Etiopathogenesismentioning

confidence: 99%

Bullous Systemic Lupus Erythematosus and Cicatricial Pemphigoid

Ayvaz¹,

Gönül²,

Atay³

2018

Autoimmune Bullous Diseases

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Bullous systemic lupus erythematosus is a rare distinctive subepidermal bullous disease seen in patients with systemic lupus erythematosus (SLE). It has characteristical clinic, pathologic, and immunologic findings including antibodies to type VII collagen, laminin 332, laminin 331, and bullous pemphigoid antigen 230. Clinical presentation combined with histopathology, immunological testing, and concomitant diagnosis of SLE according to the criteria of American College of Rheumatology, are required to distinguish bullous SLE from these bullous diseases. In patients with bullous SLE, SLE disease progression and complications may be worse. Cicatricial pemphigoid is a chronic subepidermal blistering disease which is characterized by erosive lesions of mucous membranes and skin. Pathogenesis of cicatricial pemphigoid is characterized by linear deposition of Immunoglobulin G, A, or complement 3 along the epithelial basement membrane zone. The main target antigens are bullous pemphigoid antigens 180-230, laminin 331-332, type VII collagen, and β-4 integrin subunit. Cicatricial pemphigoid may lead to serious complications such as blindness and airway obstruction. Herein, clinical, histological, immunopathological features, the diagnosis and treatment of bullous SLE and cicatricial pemphigoid diseases are mentioned to raise awareness among the dermatologists about this important but rare heterogeneous bullous disease.

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HIV Patient with Mucous Membrane Pemphigoid: A Case Report

Cited by 6 publications

References 10 publications

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree

Autoimmune blistering disorders in the setting of human immunodeficiency virus infection

Bullous Systemic Lupus Erythematosus and Cicatricial Pemphigoid

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