2022
DOI: 10.1101/2022.05.19.492600
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HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome

Abstract: This study characterized compositional and functional shifts in the intestinal and oral microbiome in HIV-positive patients compared to uninfected individuals. 79 specimens were collected from 5 HIV-positive and 12 control subjects from five locations (colon brush, colon wash, TI brush, TI wash and saliva) during colonoscopy and at patient visits. Microbiome composition was characterized using 16S rRNA sequencing and microbiome function was predicted using bioinformatics tools (PICRUSt and Bugbase). Our analys… Show more

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